Disintegrin and metalloproteinase domain-containing protein 17

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• integrin binding Source: Ensembl
• interleukin-6 receptor binding Source: Ensembl
• metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Ensembl
• Notch binding Source: Ensembl
• PDZ domain binding Source: Ensembl
• SH3 domain binding Source: UniProtKB-KW

GO - Biological processⁱ

• cell adhesion mediated by integrin Source: Ensembl
• cellular response to high density lipoprotein particle stimulus Source: Ensembl
• defense response to Gram-positive bacterium Source: Ensembl
• epidermal growth factor receptor signaling pathway Source: Ensembl
• membrane protein ectodomain proteolysis Source: Ensembl
• negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• Notch receptor processing Source: Ensembl
• positive regulation of blood vessel endothelial cell migration Source: Ensembl
• positive regulation of cell growth Source: Ensembl
• positive regulation of chemokine production Source: Ensembl
• positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
• positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
• positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
• positive regulation of T cell chemotaxis Source: Ensembl
• positive regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
• positive regulation of vascular endothelial cell proliferation Source: Ensembl
• protein processing Source: Ensembl
• receptor transactivation Source: Ensembl
• response to hypoxia Source: Ensembl
• response to lipopolysaccharide Source: Ensembl
• wound healing, spreading of epidermal cells Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• integrin binding Source: Ensembl
• interleukin-6 receptor binding Source: Ensembl
• Notch binding Source: Ensembl
• PDZ domain binding Source: Ensembl
• SH3 domain binding Source: UniProtKB-KW

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRRRLLILTT LVPFVLAPRP PEEAGSGSHP RLEKLDSLLS DYDILSLANI 
        60         70         80         90        100
QQHSIRKRDL QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD 
       110        120        130        140        150
GKEESEYSVK WQNFFSGHVV GEPDSRVLAH IGDDDVTVRI NTDGAEYNVE 
       160        170        180        190        200
PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS PKVCGYLNAD SEELLPKGLI 
       210        220        230        240        250
DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG RGEESTTTNY 
       260        270        280        290        300
LGYISGTRDR VTTDCFLEFL IELIDRVDDI YRNTSWDNAG FKGYGVQIEQ 
       310        320        330        340        350
IRILKSPQEV KPGERHFNMA KSFPNEEKDA WDVKMLLEQF SFDIAEEASK 
       360        370        380        390        400
VCLAHLFTYQ DFDMGTLGLA YVGSPRANSH GGVCPKAYYN PTVKKNIYLN 
       410        420        430        440        450
SGLTSTKNYG KTILTKEADL VTTHELGHNF GAEHDPDGLA ECAPNEDQGG 
       460        470        480        490        500
KYVMYPIAVS GDHENNKMFS NCSKQSIYKT IESKAQECFQ ERSNKVCGNS 
       510        520        530        540        550
RVDEGEECDP GIMYLNNDTC CNSDCTLKPG VQCSDRNSPC CKNCQFETAQ 
       560        570        580        590        600
KKCQEAINAT CKGVSYCTGN SSECPPPGDA EDDTVCLDLG KCKAGKCIPF 
       610        620        630        640        650
CKREQELESC ACVDTDNSCK VCCRNLSGPC VPYVDAEQKN LFLRKGKPCT 
       660        670        680        690        700
VGFCDMNGKC EKRVQDVIER FWDFIDQLSI NTFGKFLADN IVGSVLVFSL 
       710        720        730        740        750
IFWIPFSILV HCVDKKLDKQ YESLSLFHHS NIEMLSSMDS ASVRIIKPFP 
       760        770        780        790        800
APQTPGRLQA LQPAAMMPPV PAAPKLDHQR MDTIQEDPST DSHADDDGFE 
       810        820        830        840 
KDPFPNSSTA AKSFEDLTDH PVTRSEKAAS FKLQRQSRVD SKETEC     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ