UniProtKB - E9PXU2 (E9PXU2_MOUSE)
Protein
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 17
Gene
Adam17
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- integrin binding Source: Ensembl
- interleukin-6 receptor binding Source: Ensembl
- metalloendopeptidase activity Source: Ensembl
- Notch binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion mediated by integrin Source: Ensembl
- cellular response to high density lipoprotein particle stimulus Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- Notch receptor processing Source: Ensembl
- PMA-inducible membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of blood vessel endothelial cell migration Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- positive regulation of T cell chemotaxis Source: Ensembl
- positive regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
- positive regulation of vascular endothelial cell proliferation Source: Ensembl
- receptor transactivation Source: Ensembl
- response to hypoxia Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- wound healing, spreading of epidermal cells Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Disintegrin and metalloproteinase domain-containing protein 17Imported |
Gene namesi | Name:Adam17Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096335, Adam17 |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- integral component of plasma membrane Source: Ensembl
- ruffle membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- cell-cell junction Source: Ensembl
- focal adhesion Source: Ensembl
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 691 – 713 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5003243020 | 18 – 846 | Sequence analysisAdd BLAST | 829 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotationProteomic databases
jPOSTi | E9PXU2 |
MaxQBi | E9PXU2 |
PeptideAtlasi | E9PXU2 |
PRIDEi | E9PXU2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052593, Expressed in saccule of membranous labyrinth and 266 other tissues |
ExpressionAtlasi | E9PXU2, baseline and differential |
Interactioni
GO - Molecular functioni
- integrin binding Source: Ensembl
- interleukin-6 receptor binding Source: Ensembl
- Notch binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- SH3 domain binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 493 | Peptidase M12BInterPro annotationAdd BLAST | 271 | |
Domaini | 494 – 582 | DisintegrinInterPro annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 785 – 846 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 785 – 802 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 817 – 846 | PolyampholyteSequence analysisAdd BLAST | 30 |
Keywords - Domaini
SH3-bindingARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155443 |
OrthoDBi | 162519at2759 |
Family and domain databases
CDDi | cd14246, ADAM17_MPD, 1 hit cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR032029, ADAM17_MPD IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF16698, ADAM17_MPD, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9PXU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRRLLILTT LVPFVLAPRP PEEAGSGSHP RLEKLDSLLS DYDILSLANI
60 70 80 90 100
QQHSIRKRDL QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD
110 120 130 140 150
GKEESEYSVK WQNFFSGHVV GEPDSRVLAH IGDDDVTVRI NTDGAEYNVE
160 170 180 190 200
PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS PKVCGYLNAD SEELLPKGLI
210 220 230 240 250
DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG RGEESTTTNY
260 270 280 290 300
LGYISGTRDR VTTDCFLEFL IELIDRVDDI YRNTSWDNAG FKGYGVQIEQ
310 320 330 340 350
IRILKSPQEV KPGERHFNMA KSFPNEEKDA WDVKMLLEQF SFDIAEEASK
360 370 380 390 400
VCLAHLFTYQ DFDMGTLGLA YVGSPRANSH GGVCPKAYYN PTVKKNIYLN
410 420 430 440 450
SGLTSTKNYG KTILTKEADL VTTHELGHNF GAEHDPDGLA ECAPNEDQGG
460 470 480 490 500
KYVMYPIAVS GDHENNKMFS NCSKQSIYKT IESKAQECFQ ERSNKVCGNS
510 520 530 540 550
RVDEGEECDP GIMYLNNDTC CNSDCTLKPG VQCSDRNSPC CKNCQFETAQ
560 570 580 590 600
KKCQEAINAT CKGVSYCTGN SSECPPPGDA EDDTVCLDLG KCKAGKCIPF
610 620 630 640 650
CKREQELESC ACVDTDNSCK VCCRNLSGPC VPYVDAEQKN LFLRKGKPCT
660 670 680 690 700
VGFCDMNGKC EKRVQDVIER FWDFIDQLSI NTFGKFLADN IVGSVLVFSL
710 720 730 740 750
IFWIPFSILV HCVDKKLDKQ YESLSLFHHS NIEMLSSMDS ASVRIIKPFP
760 770 780 790 800
APQTPGRLQA LQPAAMMPPV PAAPKLDHQR MDTIQEDPST DSHADDDGFE
810 820 830 840
KDPFPNSSTA AKSFEDLTDH PVTRSEKAAS FKLQRQSRVD SKETEC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Z0F8 | ADA17_MOUSE | Disintegrin and metalloproteinase d... | Adam17 Tace | 827 | Annotation score: | ||
A0A338P6F3 | A0A338P6F3_MOUSE | Disintegrin and metalloproteinase d... | Adam17 | 38 | Annotation score: | ||
J3QNB3 | J3QNB3_MOUSE | Disintegrin and metalloproteinase d... | Adam17 | 222 | Annotation score: | ||
A0A338P6I8 | A0A338P6I8_MOUSE | Disintegrin and metalloproteinase d... | Adam17 | 123 | Annotation score: | ||
J3QMF2 | J3QMF2_MOUSE | Disintegrin and metalloproteinase d... | Adam17 | 94 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC140457 Genomic DNA No translation available. AC156032 Genomic DNA No translation available. |
RefSeqi | NP_001264195.1, NM_001277266.1 |
Genome annotation databases
Ensembli | ENSMUST00000101551; ENSMUSP00000099087; ENSMUSG00000052593 |
GeneIDi | 11491 |
UCSCi | uc011yks.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC140457 Genomic DNA No translation available. AC156032 Genomic DNA No translation available. |
RefSeqi | NP_001264195.1, NM_001277266.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | E9PXU2 |
MaxQBi | E9PXU2 |
PeptideAtlasi | E9PXU2 |
PRIDEi | E9PXU2 |
Protocols and materials databases
Antibodypediai | 2540, 917 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000101551; ENSMUSP00000099087; ENSMUSG00000052593 |
GeneIDi | 11491 |
UCSCi | uc011yks.2, mouse |
Organism-specific databases
CTDi | 6868 |
MGIi | MGI:1096335, Adam17 |
Phylogenomic databases
GeneTreei | ENSGT00940000155443 |
OrthoDBi | 162519at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11491, 1 hit in 17 CRISPR screens |
ChiTaRSi | Adam17, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052593, Expressed in saccule of membranous labyrinth and 266 other tissues |
ExpressionAtlasi | E9PXU2, baseline and differential |
Family and domain databases
CDDi | cd14246, ADAM17_MPD, 1 hit cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR032029, ADAM17_MPD IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF16698, ADAM17_MPD, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PXU2_MOUSE | |
Accessioni | E9PXU2Primary (citable) accession number: E9PXU2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |