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UniProtKB - E9PXQ7 (E9PXQ7_MOUSE)

Entry version 80 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Protocadherin 10

Gene

Pcdh10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation
LigandCalciumPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protocadherin 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pcdh10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1338042, Pcdh10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei714 – 738HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324430519 – 1057Sequence analysisAdd BLAST1039

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9PXQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9PXQ7

PRoteomics IDEntifications database

More...PRIDEi		E9PXQ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		355055

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		E9PXQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000049100, Expressed in midbrain and 179 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9PXQ7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000131073

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		E9PXQ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9PXQ7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 122CadherinInterPro annotationAdd BLAST107
Domaini123 – 250CadherinInterPro annotationAdd BLAST128
Domaini251 – 358CadherinInterPro annotationAdd BLAST108
Domaini359 – 463CadherinInterPro annotationAdd BLAST105
Domaini464 – 574CadherinInterPro annotationAdd BLAST111
Domaini590 – 680CadherinInterPro annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni207 – 228DisorderedSequence analysisAdd BLAST22
Regioni686 – 709DisorderedSequence analysisAdd BLAST24
Regioni899 – 930DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi908 – 924Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158277

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006480_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E9PXQ7

Database of Orthologous Groups

More...OrthoDBi		64478at2759

TreeFam database of animal gene trees

More...TreeFami		TF352008

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR032455, Cadherin_C
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030712, Protocadherin-10

The PANTHER Classification System

More...PANTHERi		PTHR24028:SF0, PTHR24028:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit
PF16492, Cadherin_C_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 4 hits
PS50268, CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PXQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVLLFFALL WMVDGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA 
        60         70         80         90        100
RRFQTVANSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE 
       110        120        130        140        150
NPLELFRVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD 
       160        170        180        190        200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV 
       210        220        230        240        250
LTAVDGGGGG GGGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF 
       260        270        280        290        300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL 
       310        320        330        340        350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD 
       360        370        380        390        400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD 
       410        420        430        440        450
VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ 
       460        470        480        490        500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAKLTY 
       510        520        530        540        550
SILECQIQGM SVFTYVSINS DNGYLYALRS FDYEQIKDFS FQVEARDAGS 
       560        570        580        590        600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL 
       610        620        630        640        650
TRVAAVDADD GENARLTYSI VRGNEMNLFR LDWRTGELRT ARRVPAKRDP 
       660        670        680        690        700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG DRGGGSGEHL 
       710        720        730        740        750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT 
       760        770        780        790        800
CLASDCCLCC CCCGNGSSTC CGRQARARKK KLSKSDIMLV QSANVPSNPA 
       810        820        830        840        850
QVPVEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDAEH 
       860        870        880        890        900
NPCGAIVTGY SDQQPDIISN GSILSNENKH QRAELSYLVD RPRRVNSSAF 
       910        920        930        940        950
QEADIVSSKD SGHGDSEQGD SDHDVTNRGQ SAGMDLFSNC TEECKALGHS 
       960        970        980        990       1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFEPP EVQPGAERSF 
      1010       1020       1030       1040       1050
STFGKEKALH GTLERKELDG LLSNTRAPYK PPYLKMLWMQ LRGEAHLTKD 

GGKQTTT
Length:1,057
Mass (Da):115,000
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30D34C83B6F3EC51
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q925I8Q925I8_MOUSE
OL-protocadherin isoform
Pcdh10 Pcadh10
1,040Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX28E9PX28_MOUSE
Protocadherin 10
Pcdh10
1,047Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6P0A6Q6P0A6_MOUSE
Protocadherin 10
Pcdh10
896Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_001091640.1, NM_001098170.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000166126; ENSMUSP00000131073; ENSMUSG00000049100

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18526

UCSC genome browser

More...UCSCi		uc008pda.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001091640.1, NM_001098170.1

3D structure databases

SMRiE9PXQ7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131073

PTM databases

SwissPalmiE9PXQ7

Proteomic databases

MaxQBiE9PXQ7
PaxDbiE9PXQ7
PRIDEiE9PXQ7
ProteomicsDBi355055

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2468, 160 antibodies

The DNASU plasmid repository

More...DNASUi		18526

Genome annotation databases

EnsembliENSMUST00000166126; ENSMUSP00000131073; ENSMUSG00000049100
GeneIDi18526
KEGGimmu:18526
UCSCiuc008pda.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57575
MGIiMGI:1338042, Pcdh10

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT00940000158277
HOGENOMiCLU_006480_1_1_1
InParanoidiE9PXQ7
OrthoDBi64478at2759
TreeFamiTF352008

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18526, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pcdh10, mouse
RNActiE9PXQ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000049100, Expressed in midbrain and 179 other tissues
GenevisibleiE9PXQ7, MM

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR032455, Cadherin_C
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030712, Protocadherin-10
PANTHERiPTHR24028:SF0, PTHR24028:SF0, 1 hit
PfamiView protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit
PF16492, Cadherin_C_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 6 hits
SUPFAMiSSF49313, SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 4 hits
PS50268, CADHERIN_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PXQ7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PXQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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