UniProtKB - E9PXQ7 (E9PXQ7_MOUSE)
Protein
Submitted name:
Protocadherin 10
Gene
Pcdh10
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell adhesion Source: MGI
- homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
Keywordsi
Biological process | Cell adhesionARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protocadherin 10Imported |
Gene namesi | Name:Pcdh10Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338042, Pcdh10 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 714 – 738 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5003244305 | 19 – 1057 | Sequence analysisAdd BLAST | 1039 |
Proteomic databases
MaxQBi | E9PXQ7 |
PaxDbi | E9PXQ7 |
PRIDEi | E9PXQ7 |
PTM databases
SwissPalmi | E9PXQ7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000049100, Expressed in frontal cortex and 171 other tissues |
Genevisiblei | E9PXQ7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131073 |
Miscellaneous databases
RNActi | E9PXQ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 122 | CadherinInterPro annotationAdd BLAST | 107 | |
Domaini | 123 – 250 | CadherinInterPro annotationAdd BLAST | 128 | |
Domaini | 251 – 358 | CadherinInterPro annotationAdd BLAST | 108 | |
Domaini | 359 – 463 | CadherinInterPro annotationAdd BLAST | 105 | |
Domaini | 464 – 574 | CadherinInterPro annotationAdd BLAST | 111 | |
Domaini | 590 – 680 | CadherinInterPro annotationAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 207 – 228 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 686 – 709 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 899 – 930 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 908 – 924 | PolyampholyteSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000158277 |
HOGENOMi | CLU_006480_1_1_1 |
InParanoidi | E9PXQ7 |
OrthoDBi | 64478at2759 |
TreeFami | TF352008 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030712, Protocadherin-10 |
PANTHERi | PTHR24028:SF0, PTHR24028:SF0, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9PXQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVLLFFALL WMVDGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA
60 70 80 90 100
RRFQTVANSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE
110 120 130 140 150
NPLELFRVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD
160 170 180 190 200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV
210 220 230 240 250
LTAVDGGGGG GGGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF
260 270 280 290 300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
310 320 330 340 350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD
360 370 380 390 400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD
410 420 430 440 450
VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ
460 470 480 490 500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAKLTY
510 520 530 540 550
SILECQIQGM SVFTYVSINS DNGYLYALRS FDYEQIKDFS FQVEARDAGS
560 570 580 590 600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
610 620 630 640 650
TRVAAVDADD GENARLTYSI VRGNEMNLFR LDWRTGELRT ARRVPAKRDP
660 670 680 690 700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG DRGGGSGEHL
710 720 730 740 750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT
760 770 780 790 800
CLASDCCLCC CCCGNGSSTC CGRQARARKK KLSKSDIMLV QSANVPSNPA
810 820 830 840 850
QVPVEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDAEH
860 870 880 890 900
NPCGAIVTGY SDQQPDIISN GSILSNENKH QRAELSYLVD RPRRVNSSAF
910 920 930 940 950
QEADIVSSKD SGHGDSEQGD SDHDVTNRGQ SAGMDLFSNC TEECKALGHS
960 970 980 990 1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFEPP EVQPGAERSF
1010 1020 1030 1040 1050
STFGKEKALH GTLERKELDG LLSNTRAPYK PPYLKMLWMQ LRGEAHLTKD
GGKQTTT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ925I8 | Q925I8_MOUSE | OL-protocadherin isoform | Pcdh10 Pcadh10 | 1,040 | Annotation score: | ||
E9PX28 | E9PX28_MOUSE | Protocadherin 10 | Pcdh10 | 1,047 | Annotation score: | ||
Q6P0A6 | Q6P0A6_MOUSE | Protocadherin 10 | Pcdh10 | 896 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108393 Genomic DNA No translation available. |
RefSeqi | NP_001091640.1, NM_001098170.1 |
Genome annotation databases
Ensembli | ENSMUST00000166126; ENSMUSP00000131073; ENSMUSG00000049100 |
GeneIDi | 18526 |
KEGGi | mmu:18526 |
UCSCi | uc008pda.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108393 Genomic DNA No translation available. |
RefSeqi | NP_001091640.1, NM_001098170.1 |
3D structure databases
SMRi | E9PXQ7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000131073 |
PTM databases
SwissPalmi | E9PXQ7 |
Proteomic databases
MaxQBi | E9PXQ7 |
PaxDbi | E9PXQ7 |
PRIDEi | E9PXQ7 |
Protocols and materials databases
Antibodypediai | 2468, 157 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000166126; ENSMUSP00000131073; ENSMUSG00000049100 |
GeneIDi | 18526 |
KEGGi | mmu:18526 |
UCSCi | uc008pda.1, mouse |
Organism-specific databases
CTDi | 57575 |
MGIi | MGI:1338042, Pcdh10 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000158277 |
HOGENOMi | CLU_006480_1_1_1 |
InParanoidi | E9PXQ7 |
OrthoDBi | 64478at2759 |
TreeFami | TF352008 |
Miscellaneous databases
BioGRID-ORCSi | 18526, 3 hits in 17 CRISPR screens |
ChiTaRSi | Pcdh10, mouse |
RNActi | E9PXQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049100, Expressed in frontal cortex and 171 other tissues |
Genevisiblei | E9PXQ7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030712, Protocadherin-10 |
PANTHERi | PTHR24028:SF0, PTHR24028:SF0, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 4 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PXQ7_MOUSE | |
Accessioni | E9PXQ7Primary (citable) accession number: E9PXQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |