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Protein
Submitted name:

SET-binding factor 2

Gene

Sbf2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Submitted name:
SET-binding factor 2Imported
Gene namesi
Name:Sbf2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921831 Sbf2

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9PXF8
PaxDbiE9PXF8
PeptideAtlasiE9PXF8
PRIDEiE9PXF8

PTM databases

iPTMnetiE9PXF8
PhosphoSitePlusiE9PXF8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038371 Expressed in 288 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiE9PXF8 baseline and differential
GenevisibleiE9PXF8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033058

Structurei

3D structure databases

ProteinModelPortaliE9PXF8
SMRiE9PXF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 427UDENNInterPro annotationAdd BLAST421
Domaini1106 – 1607Myotubularin phosphataseInterPro annotationAdd BLAST502
Domaini1766 – 1870PHInterPro annotationAdd BLAST105

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.SAAS annotation

Phylogenomic databases

eggNOGiKOG1090 Eukaryota
KOG4471 Eukaryota
ENOG410XTJ1 LUCA
GeneTreeiENSGT00760000118832
InParanoidiE9PXF8
KOiK18061
OrthoDBiEOG091G00CQ
TreeFamiTF318583

Family and domain databases

CDDicd13339 PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF4 PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E9PXF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLADYFIV VGYDHEKPAG PGEGLGKIIQ RFPQQDWDDT PFPQGIELFC
60 70 80 90 100
QPGGWHLSRE RKQPTFFVVV LTDIDSDRHY CSCLTFYEAE INLQGTKKEE
110 120 130 140 150
IEGEEVSGLI QPAEVFAPKS LVLVSRLDYP EIFRACLGLI YTVYVDSMSV
160 170 180 190 200
SLESLIANLC ACLVPAAGGS QKLFSLGAGD RQLIQTPLHD SLPVTGTSVA
210 220 230 240 250
LLFQQLGIQN VLNLFCAVLT ENKVLFHSAS FQRLSDACRA LESLMFPLKY
260 270 280 290 300
SYPYIPILPA QLLEVLSSPT PFIIGVHSIF KTDVHELLDV IIADLDGGTI
310 320 330 340 350
KIPECIHLSS LPEPLLHQTQ SALSLILHPD LEVADHAFPP PRTALSHSKM
360 370 380 390 400
LDKEVRAVFL RLFAQLFQGY RSCLQLIRIH AEPVIHFHKT AFLGQRGLVE
410 420 430 440 450
NDFLTKVLNG MAFAGFVSER GPPYRACDLF DELVAFEVER IKVEEKNPLK
460 470 480 490 500
MIKHIRELAE QLFKNENPNP HMAFQKVPRP TEGSHLRVHI LPFPKINEAR
510 520 530 540 550
VQELIQENLA KNQNAPPATR IEKKCVVPAG PPVVSIMEKV ITVFNSAQRL
560 570 580 590 600
EVVRNCISFI FENKTLETEK TLPAALRALK GKAARQCLTD ELGLHVQQNR
610 620 630 640 650
AILDHQQFDY IIRMMNCTLQ DCSSLEEYNI AAALLPLTSA FYRKLAPGVS
660 670 680 690 700
QFAYTCVQDH PIWTNQQFWE TTFYNAVQEQ VRSLYLSAKD DNHIPHLKQK
710 720 730 740 750
LPDGQHQEKT AMDLAAEQLR LWPTLSKSTQ QELVQHEEST VFSQAIHFAN
760 770 780 790 800
LMVNLLVPLD TSKNKLLRAS APGDWESGSN SIVTNSIAGS VAESYDTESG
810 820 830 840 850
FEDSENSDVA NSVVRFIARF IDKVCTESGV TQDHIRSLHC MIPGIVAMHI
860 870 880 890 900
ETLEAVHRES RRLPPIQKPK ILRPALLPGE EIVCEGLRVL LDPDGREEAT
910 920 930 940 950
GGLLGGPQLL PAEGALFLTT YRILFRGTPH DQLVGEQTVV RSFPIASITK
960 970 980 990 1000
EKKITMQNQL QQSVQEGLQI TSASFQLIKV AFDEEVSPEV VDIFKKQLMK
1010 1020 1030 1040 1050
FRYPQSIFST FAFAAGQTTP QIILPKQKEK NTSFRTFSKT IVKGAKKAGK
1060 1070 1080 1090 1100
MTIGRQYLLK KRTGTIVEER VNRPGWNEED DISVSDDSEL PTSTTLKASE
1110 1120 1130 1140 1150
KSTMEQLVEK ACFRDYQRLG LGTISGNSSR SKPEYFRVTA SNRLYSLCRS
1160 1170 1180 1190 1200
YPGLLVIPQA VQDSSLPRVA RCYRHNRLPV VCWKNSRSGT LLLRSGGFHG
1210 1220 1230 1240 1250
KGVVGLFKSQ NSPQAVSTSS LESSSSIEQE KYLQALLTAV IVHQKLRGSS
1260 1270 1280 1290 1300
TLTVRPALAL SPVHGYRDKS FTQSNPKSSA KEPVHNQGVW ASLRSSTRLI
1310 1320 1330 1340 1350
SSPTSFIDVG ARLAGKDHSA SFSNSTYLQN QLLKRQAALY IFGEKSQLRS
1360 1370 1380 1390 1400
SKVEFAFNCE FVPVEFHEIR QVKASFKKLM RACIPSTIPT DSEVTFLKAL
1410 1420 1430 1440 1450
GDSEWFPQLH RIMQLAVVVS EVLENGSSVW VCLEEGWDIT TQVTSLAQLL
1460 1470 1480 1490 1500
SDPFYRTIAG FRTLVEKEWL SFGHKFSQRS SLALNSQGGG FAPIFLQFLD
1510 1520 1530 1540 1550
CVHQVHNQYP TEFEFNLYYL KFLAFHYVSN RFKTFLLDSD YERLEHGTLF
1560 1570 1580 1590 1600
DDKGDKHAKK GVCIWECIDK MHTRSPIFFN YLYSPVEVEA LKPNVNVSSL
1610 1620 1630 1640 1650
KKWDYYTEET LSAGPSYDWM MLTPKHFPYE ESDVAGGAGP QSQRKTVWPC
1660 1670 1680 1690 1700
YDDVTCSQPD ALTRLFSEIE KLEHKLNQTP ERWHQLWEKV TTDLKEEPRT
1710 1720 1730 1740 1750
AHSLRHSAGS PGIASTNVPS YQKRPALHPL HRGLGEDQST TTAPSNGVEH
1760 1770 1780 1790 1800
RAATLYSQYT SKNDENRSFE GTLYKRGALL KGWKPRWFVL DVTKHQLRYY
1810 1820 1830 1840 1850
DSGEDTSCKG HIDLAEVEMV IPAGPSMGAP KYTSDKAFFD LKTSKRVYNF
1860 1870
CAQDGQSAQQ WMDRIQSCIS DA
Length:1,872
Mass (Da):210,458
Last modified:April 5, 2011 - v1
Checksum:iF3D86BAEA404F561
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q305E9Q305_MOUSE
SET-binding factor 2
Sbf2
1,847Annotation score:
E9Q0D4E9Q0D4_MOUSE
SET-binding factor 2
Sbf2
1,826Annotation score:
F7BBM8F7BBM8_MOUSE
SET-binding factor 2
Sbf2
245Annotation score:
F6ZDC5F6ZDC5_MOUSE
SET-binding factor 2
Sbf2
339Annotation score:
F6QZ02F6QZ02_MOUSE
SET-binding factor 2
Sbf2
198Annotation score:
F6QG63F6QG63_MOUSE
SET-binding factor 2
Sbf2
177Annotation score:
E9Q372E9Q372_MOUSE
SET-binding factor 2
Sbf2
408Annotation score:
E9Q4I8E9Q4I8_MOUSE
SET-binding factor 2
Sbf2
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122921 Genomic DNA No translation available.
AC124472 Genomic DNA No translation available.
AC154911 Genomic DNA No translation available.
RefSeqiNP_796298.2, NM_177324.2
UniGeneiMm.102970

Genome annotation databases

EnsembliENSMUST00000033058; ENSMUSP00000033058; ENSMUSG00000038371
GeneIDi319934
KEGGimmu:319934
UCSCiuc009jfe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122921 Genomic DNA No translation available.
AC124472 Genomic DNA No translation available.
AC154911 Genomic DNA No translation available.
RefSeqiNP_796298.2, NM_177324.2
UniGeneiMm.102970

3D structure databases

ProteinModelPortaliE9PXF8
SMRiE9PXF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033058

PTM databases

iPTMnetiE9PXF8
PhosphoSitePlusiE9PXF8

Proteomic databases

MaxQBiE9PXF8
PaxDbiE9PXF8
PeptideAtlasiE9PXF8
PRIDEiE9PXF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033058; ENSMUSP00000033058; ENSMUSG00000038371
GeneIDi319934
KEGGimmu:319934
UCSCiuc009jfe.2 mouse

Organism-specific databases

CTDi81846
MGIiMGI:1921831 Sbf2

Phylogenomic databases

eggNOGiKOG1090 Eukaryota
KOG4471 Eukaryota
ENOG410XTJ1 LUCA
GeneTreeiENSGT00760000118832
InParanoidiE9PXF8
KOiK18061
OrthoDBiEOG091G00CQ
TreeFamiTF318583

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiSbf2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038371 Expressed in 288 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiE9PXF8 baseline and differential
GenevisibleiE9PXF8 MM

Family and domain databases

CDDicd13339 PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF4 PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PXF8_MOUSE
AccessioniPrimary (citable) accession number: E9PXF8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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