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UniProtKB - E9PXF8 (MTMRD_MOUSE)

Entry version 77 (16 Oct 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Myotubularin-related protein 13

Gene

Sbf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794).By similarity1 Publication

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1433 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated
MTMR2 protein levels are decreased in sciatic nerves but not in the brain (PubMed:18349142, PubMed:23297362). However, MTMR2 protein levels have also been shown not to be affected in sciatic nerves (PubMed:17855448).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAutophagy

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 13Curated
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 13Curated
SET-binding factor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sbf2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921831 Sbf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are born at the expected Mendelian rate (PubMed:18349142). Display demyelinating peripheral neuropathy characterized by slowed nerve conduction velocity, axon degeneration, and myelin outfolding and infolding in motor and sensory peripheral nerves (PubMed:17855448, PubMed:18349142, PubMed:23297362). Defects in myelination start to appear at postnatal day 3 (P3) (PubMed:23297362). The neuropathy severity increases with age (PubMed:17855448, PubMed:23297362).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004463661 – 1872Myotubularin-related protein 13Add BLAST1872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1125PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9PXF8

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9PXF8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9PXF8

PeptideAtlas

More...PeptideAtlasi		E9PXF8

PRoteomics IDEntifications database

More...PRIDEi		E9PXF8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9PXF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9PXF8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		E9PXF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in sciatic nerve and in Schwann cells (at protein level) (PubMed:16750429, PubMed:16399794, PubMed:17855448, PubMed:18349142, PubMed:23297362). Expressed in brain (at protein level) (PubMed:18349142, PubMed:22648168). Highly expressed in brain, heart, kidney and testis, and to a lesser extent in lung, stomach, small intestine, skeletal muscle, liver and placenta (PubMed:16750429). Expressed in spinal cord and eye (PubMed:16750429). Not expressed in thymus and spleen (PubMed:16750429).6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In 9 dpc embryos, strongly expressed in the craniofacial region, the branchial arches and in limb buds. Also expressed in brain and along the neural tube. At 9 dpc and 10 dpc, no expression is detected in the heart but at later stages expressed weakly in the ventricle. At 11 dpc and 12 dpc, highly expressed in the neural tube, limb bud, dorsal trunk and tail mesenchyme. In the brain of 13 dpc embryos, highly expressed in the cortex and the dorsal spinal cord and weakly in midbrain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000038371 Expressed in 288 organ(s), highest expression level in sciatic nerve

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9PXF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9PXF8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:16399794). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:16399794).

Interacts with class II PI3-kinase PIK3C2A (PubMed:22648168).

Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (By similarity).

Interacts with VAMP8 in response to starvation (By similarity).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		E9PXF8, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000033058

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9PXF8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 172uDENNPROSITE-ProRule annotationAdd BLAST166
Domaini191 – 324cDENNPROSITE-ProRule annotationAdd BLAST134
Domaini326 – 427dDENNPROSITE-ProRule annotationAdd BLAST102
Domaini869 – 1004GRAMSequence analysisAdd BLAST136
Domaini1106 – 1607Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST502
Domaini1766 – 1870PHPROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1652 – 1705Required for homodimerization and interaction with MTMR2By similarity1 PublicationAdd BLAST54

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain mediates homodimerization (PubMed:16399794). By mediating SBF2/MTMR13 homodimerization, indirectly involved in SBF2/MTMR13 and MTMR2 homotetramerization (PubMed:16399794).1 Publication
The GRAM domain mediates binding to phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3,4,5-trisphosphate.1 Publication
The PH domain binds preferentially phosphatidylinositol 3,4,5-trisphosphate (PubMed:16399794). Appears to be dispensable for localization to membranes (PubMed:23297362).2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1090 Eukaryota
KOG4471 Eukaryota
ENOG410XTJ1 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155385

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000044360

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E9PXF8

KEGG Orthology (KO)

More...KOi		K18061

Identification of Orthologs from Complete Genome Data

More...OMAi		PNAYVCL

Database of Orthologous Groups

More...OrthoDBi		EOG091G00CQ

TreeFam database of animal gene trees

More...TreeFami		TF318583

Family and domain databases

Conserved Domains Database

More...CDDi		cd13339 PH-GRAM_MTMR13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...PANTHERi		PTHR10807 PTHR10807, 1 hit
PTHR10807:SF4 PTHR10807:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: E9PXF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARLADYFIV VGYDHEKPAG PGEGLGKIIQ RFPQQDWDDT PFPQGIELFC 
        60         70         80         90        100
QPGGWHLSRE RKQPTFFVVV LTDIDSDRHY CSCLTFYEAE INLQGTKKEE 
       110        120        130        140        150
IEGEEVSGLI QPAEVFAPKS LVLVSRLDYP EIFRACLGLI YTVYVDSMSV 
       160        170        180        190        200
SLESLIANLC ACLVPAAGGS QKLFSLGAGD RQLIQTPLHD SLPVTGTSVA 
       210        220        230        240        250
LLFQQLGIQN VLNLFCAVLT ENKVLFHSAS FQRLSDACRA LESLMFPLKY 
       260        270        280        290        300
SYPYIPILPA QLLEVLSSPT PFIIGVHSIF KTDVHELLDV IIADLDGGTI 
       310        320        330        340        350
KIPECIHLSS LPEPLLHQTQ SALSLILHPD LEVADHAFPP PRTALSHSKM 
       360        370        380        390        400
LDKEVRAVFL RLFAQLFQGY RSCLQLIRIH AEPVIHFHKT AFLGQRGLVE 
       410        420        430        440        450
NDFLTKVLNG MAFAGFVSER GPPYRACDLF DELVAFEVER IKVEEKNPLK 
       460        470        480        490        500
MIKHIRELAE QLFKNENPNP HMAFQKVPRP TEGSHLRVHI LPFPKINEAR 
       510        520        530        540        550
VQELIQENLA KNQNAPPATR IEKKCVVPAG PPVVSIMEKV ITVFNSAQRL 
       560        570        580        590        600
EVVRNCISFI FENKTLETEK TLPAALRALK GKAARQCLTD ELGLHVQQNR 
       610        620        630        640        650
AILDHQQFDY IIRMMNCTLQ DCSSLEEYNI AAALLPLTSA FYRKLAPGVS 
       660        670        680        690        700
QFAYTCVQDH PIWTNQQFWE TTFYNAVQEQ VRSLYLSAKD DNHIPHLKQK 
       710        720        730        740        750
LPDGQHQEKT AMDLAAEQLR LWPTLSKSTQ QELVQHEEST VFSQAIHFAN 
       760        770        780        790        800
LMVNLLVPLD TSKNKLLRAS APGDWESGSN SIVTNSIAGS VAESYDTESG 
       810        820        830        840        850
FEDSENSDVA NSVVRFIARF IDKVCTESGV TQDHIRSLHC MIPGIVAMHI 
       860        870        880        890        900
ETLEAVHRES RRLPPIQKPK ILRPALLPGE EIVCEGLRVL LDPDGREEAT 
       910        920        930        940        950
GGLLGGPQLL PAEGALFLTT YRILFRGTPH DQLVGEQTVV RSFPIASITK 
       960        970        980        990       1000
EKKITMQNQL QQSVQEGLQI TSASFQLIKV AFDEEVSPEV VDIFKKQLMK 
      1010       1020       1030       1040       1050
FRYPQSIFST FAFAAGQTTP QIILPKQKEK NTSFRTFSKT IVKGAKKAGK 
      1060       1070       1080       1090       1100
MTIGRQYLLK KRTGTIVEER VNRPGWNEED DISVSDDSEL PTSTTLKASE 
      1110       1120       1130       1140       1150
KSTMEQLVEK ACFRDYQRLG LGTISGNSSR SKPEYFRVTA SNRLYSLCRS 
      1160       1170       1180       1190       1200
YPGLLVIPQA VQDSSLPRVA RCYRHNRLPV VCWKNSRSGT LLLRSGGFHG 
      1210       1220       1230       1240       1250
KGVVGLFKSQ NSPQAVSTSS LESSSSIEQE KYLQALLTAV IVHQKLRGSS 
      1260       1270       1280       1290       1300
TLTVRPALAL SPVHGYRDKS FTQSNPKSSA KEPVHNQGVW ASLRSSTRLI 
      1310       1320       1330       1340       1350
SSPTSFIDVG ARLAGKDHSA SFSNSTYLQN QLLKRQAALY IFGEKSQLRS 
      1360       1370       1380       1390       1400
SKVEFAFNCE FVPVEFHEIR QVKASFKKLM RACIPSTIPT DSEVTFLKAL 
      1410       1420       1430       1440       1450
GDSEWFPQLH RIMQLAVVVS EVLENGSSVW VCLEEGWDIT TQVTSLAQLL 
      1460       1470       1480       1490       1500
SDPFYRTIAG FRTLVEKEWL SFGHKFSQRS SLALNSQGGG FAPIFLQFLD 
      1510       1520       1530       1540       1550
CVHQVHNQYP TEFEFNLYYL KFLAFHYVSN RFKTFLLDSD YERLEHGTLF 
      1560       1570       1580       1590       1600
DDKGDKHAKK GVCIWECIDK MHTRSPIFFN YLYSPVEVEA LKPNVNVSSL 
      1610       1620       1630       1640       1650
KKWDYYTEET LSAGPSYDWM MLTPKHFPYE ESDVAGGAGP QSQRKTVWPC 
      1660       1670       1680       1690       1700
YDDVTCSQPD ALTRLFSEIE KLEHKLNQTP ERWHQLWEKV TTDLKEEPRT 
      1710       1720       1730       1740       1750
AHSLRHSAGS PGIASTNVPS YQKRPALHPL HRGLGEDQST TTAPSNGVEH 
      1760       1770       1780       1790       1800
RAATLYSQYT SKNDENRSFE GTLYKRGALL KGWKPRWFVL DVTKHQLRYY 
      1810       1820       1830       1840       1850
DSGEDTSCKG HIDLAEVEMV IPAGPSMGAP KYTSDKAFFD LKTSKRVYNF 
      1860       1870 
CAQDGQSAQQ WMDRIQSCIS DA
Note: No experimental confirmation available.Curated
Length:1,872
Mass (Da):210,458
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3D86BAEA404F561
GO
Isoform 2Curated (identifier: E9PXF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1263-1287: Missing.

Show »
Length:1,847
Mass (Da):207,634
Checksum:i3945864DF3162776
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0D4E9Q0D4_MOUSE
Myotubularin-related protein 13
Sbf2
1,826Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BBM8F7BBM8_MOUSE
Myotubularin-related protein 13
Sbf2
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZDC5F6ZDC5_MOUSE
Myotubularin-related protein 13
Sbf2
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QG63F6QG63_MOUSE
Myotubularin-related protein 13
Sbf2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QZ02F6QZ02_MOUSE
Myotubularin-related protein 13
Sbf2
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q372E9Q372_MOUSE
Myotubularin-related protein 13
Sbf2
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q4I8E9Q4I8_MOUSE
Myotubularin-related protein 13
Sbf2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti300I → F in BAC39860 (PubMed:16141072).Curated1
Sequence conflicti1496L → F in AAH15069 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0600701263 – 1287Missing in isoform 2. CuratedAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC122921 Genomic DNA No translation available.
AC124472 Genomic DNA No translation available.
AC154911 Genomic DNA No translation available.
AK029568 mRNA Translation: BAC26517.1
AK080952 mRNA Translation: BAC38090.1
AK087396 mRNA Translation: BAC39860.1
BC015069 mRNA Translation: AAH15069.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS52361.1 [E9PXF8-1]

NCBI Reference Sequences

More...RefSeqi		NP_796298.2, NM_177324.2 [E9PXF8-1]
XP_006507989.1, XM_006507926.1 [E9PXF8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000033058; ENSMUSP00000033058; ENSMUSG00000038371 [E9PXF8-1]
ENSMUST00000164759; ENSMUSP00000132072; ENSMUSG00000038371 [E9PXF8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		319934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:319934

UCSC genome browser

More...UCSCi		uc009jfe.2 mouse [E9PXF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122921 Genomic DNA No translation available.
AC124472 Genomic DNA No translation available.
AC154911 Genomic DNA No translation available.
AK029568 mRNA Translation: BAC26517.1
AK080952 mRNA Translation: BAC38090.1
AK087396 mRNA Translation: BAC39860.1
BC015069 mRNA Translation: AAH15069.1
CCDSiCCDS52361.1 [E9PXF8-1]
RefSeqiNP_796298.2, NM_177324.2 [E9PXF8-1]
XP_006507989.1, XM_006507926.1 [E9PXF8-2]

3D structure databases

SMRiE9PXF8
ModBaseiSearch...

Protein-protein interaction databases

IntActiE9PXF8, 1 interactor
STRINGi10090.ENSMUSP00000033058

PTM databases

iPTMnetiE9PXF8
PhosphoSitePlusiE9PXF8
SwissPalmiE9PXF8

Proteomic databases

jPOSTiE9PXF8
MaxQBiE9PXF8
PaxDbiE9PXF8
PeptideAtlasiE9PXF8
PRIDEiE9PXF8

Genome annotation databases

EnsembliENSMUST00000033058; ENSMUSP00000033058; ENSMUSG00000038371 [E9PXF8-1]
ENSMUST00000164759; ENSMUSP00000132072; ENSMUSG00000038371 [E9PXF8-2]
GeneIDi319934
KEGGimmu:319934
UCSCiuc009jfe.2 mouse [E9PXF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81846
MGIiMGI:1921831 Sbf2

Phylogenomic databases

eggNOGiKOG1090 Eukaryota
KOG4471 Eukaryota
ENOG410XTJ1 LUCA
GeneTreeiENSGT00940000155385
HOGENOMiHOG000044360
InParanoidiE9PXF8
KOiK18061
OMAiPNAYVCL
OrthoDBiEOG091G00CQ
TreeFamiTF318583

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sbf2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000038371 Expressed in 288 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiE9PXF8 baseline and differential
GenevisibleiE9PXF8 MM

Family and domain databases

CDDicd13339 PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR004182 GRAM
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029021 Prot-tyrosine_phosphatase-like
IPR022096 SBF1/SBF2
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF4 PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
PF00169 PH, 1 hit
PF12335 SBF2, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00568 GRAM, 1 hit
SM00233 PH, 1 hit
SM00800 uDENN, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS51339 PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMRD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PXF8
Secondary accession number(s): E9Q305
, Q8BJ67, Q8BJD2, Q8BJP4, Q91VH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 13, 2019
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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