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Protein
Submitted name:

Protocadherin 17

Gene

Pcdh17

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • adult behavior Source: MGI
  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • negative regulation of synaptic transmission Source: MGI
  • presynaptic active zone assembly Source: MGI
  • regulation of synaptic vesicle clustering Source: MGI
  • synaptic membrane adhesion Source: SynGO

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protocadherin 17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pcdh17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2684924 Pcdh17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324548218 – 1157Sequence analysisAdd BLAST1140

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PXF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PXF0

PeptideAtlas

More...
PeptideAtlasi
E9PXF0

PRoteomics IDEntifications database

More...
PRIDEi
E9PXF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035566 Expressed in 232 organ(s), highest expression level in medial preoptic region

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PXF0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071325

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PXF0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PXF0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 131CAInterPro annotationAdd BLAST78
Domaini155 – 242CAInterPro annotationAdd BLAST88
Domaini266 – 350CAInterPro annotationAdd BLAST85
Domaini375 – 468CAInterPro annotationAdd BLAST94
Domaini492 – 579CAInterPro annotationAdd BLAST88
Domaini608 – 687CAInterPro annotationAdd BLAST80

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156894

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PXF0

KEGG Orthology (KO)

More...
KOi
K16499

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQGHVGC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00QD

TreeFam database of animal gene trees

More...
TreeFami
TF352008

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030709 Protocadherin-17

The PANTHER Classification System

More...
PANTHERi
PTHR24028:SF41 PTHR24028:SF41, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9PXF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGK DARLQPGLPP
60 70 80 90 100
AERGSGSGRS KSGSYRVLEN SAPHLLDVDA DSGLLYTKQR IDRESLCRHN
110 120 130 140 150
AKCQLSLEVF ANDKEICMIK VEIQDINDNA PSFPSDQIEM DISENAAPGT
160 170 180 190 200
RFPLTSAHDP DAGENGLRTY LLTRDDHGLF ALDVKSRGDG TKFPELVIQK
210 220 230 240 250
ALDRELQNHH TLVLTALDGG EPPRSATVQI NVKVIDSNDN SPVFEAPSYL
260 270 280 290 300
VELPENAPLG TVVIDLNATD ADEGPNGEVL YSFSSYVPDR VRELFSIDPK
310 320 330 340 350
TGLIRVKGNL DYEENGMLEI DVQARDLGPN PIPAHCKVTV KLIDRNDNAP
360 370 380 390 400
SIGFVSVRQG ALSEAAPPGT VIALVRVTDR DSGKNGQLQC RVLGGGGTGG
410 420 430 440 450
GLGGPGSVPF KLEENYDNFY TVVTDRPLDR ETQDEYNVTI VARDGGSPPL
460 470 480 490 500
NSTKSFAVKI LDENDNPPRF TKGLYVLQVH ENNIPGEYLG SVLAQDPDLG
510 520 530 540 550
QNGTVSYSIL PSHIGDVSIY TYVSVNPTNG AIYALRSFNY EQTKAFEFKV
560 570 580 590 600
LAKDSGAPAH LESNATVRVT VLDVNDNAPV IVLPTLQNDT AELQVPRNAG
610 620 630 640 650
LGYLVSTVRA LDSDFGESGR LTYEIVDGND DHLFEIDPSS GEIRTLHPFW
660 670 680 690 700
EDVTPVVELV VKVTDHGKPT LSAVAKLIIR SVSGSLPEGV PRVNGEQHHW
710 720 730 740 750
DMSLPLIVTL STISIILLAA MITIAVKCKR ENKEIRTYNC RIAEYSHPQL
760 770 780 790 800
GGGKGKKKKI NKNDIMLVQS EVEERNAMNV MNVVSSPSLA TSPMYFDYQT
810 820 830 840 850
RLPLSSPRSE VMYLKPASNN LTVPQGHAGC HTSFTGQGTN SSETPATRMS
860 870 880 890 900
IIQTDNFPAE PNYMGSRQQF VQSSSTFKDP ERASLRDSGH GDSDQADSDQ
910 920 930 940 950
DTNKGSCCDM SVREALKMKT TSTKSQPLEQ EPEECINCTD ECRVLGHSDR
960 970 980 990 1000
CWMPQFPAAN QAENADYRTN LFVPTVEANV ETETYETVNP TGKKTFCTFG
1010 1020 1030 1040 1050
KDKREHTILI ANVKPYLKAK RALSPLLQEV PSASSSPTKA CIEPCASTKG
1060 1070 1080 1090 1100
SLDGCEAKPG PLAEASSSYL PTDSQYPSPS KQPRDPSFMA SDQMARVFAD
1110 1120 1130 1140 1150
VHSRARRASS EMGAVLEQLE QPNRDLGRES VDAEEVVREI DKLLQDCRGN

DPVAVRK
Length:1,157
Mass (Da):126,147
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i450F1887F88E7A36
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT009510 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001013775.2, NM_001013753.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.153643

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000071370; ENSMUSP00000071325; ENSMUSG00000035566

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:219228

UCSC genome browser

More...
UCSCi
uc007uto.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009510 Genomic DNA No translation available.
RefSeqiNP_001013775.2, NM_001013753.2
UniGeneiMm.153643

3D structure databases

ProteinModelPortaliE9PXF0
SMRiE9PXF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071325

Proteomic databases

MaxQBiE9PXF0
PaxDbiE9PXF0
PeptideAtlasiE9PXF0
PRIDEiE9PXF0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071370; ENSMUSP00000071325; ENSMUSG00000035566
GeneIDi219228
KEGGimmu:219228
UCSCiuc007uto.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27253
MGIiMGI:2684924 Pcdh17

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000156894
InParanoidiE9PXF0
KOiK16499
OMAiPQGHVGC
OrthoDBiEOG091G00QD
TreeFamiTF352008

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035566 Expressed in 232 organ(s), highest expression level in medial preoptic region
GenevisibleiE9PXF0 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030709 Protocadherin-17
PANTHERiPTHR24028:SF41 PTHR24028:SF41, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PXF0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PXF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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