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Protein
Submitted name:

Protocadherin 10

Gene

Pcdh10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin 10Imported
Gene namesi
Name:Pcdh10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338042 Pcdh10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei714 – 738HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500324300819 – 1047Sequence analysisAdd BLAST1029

Proteomic databases

MaxQBiE9PX28
PeptideAtlasiE9PX28
PRIDEiE9PX28

PTM databases

SwissPalmiE9PX28

Expressioni

Gene expression databases

BgeeiENSMUSG00000049100 Expressed in 146 organ(s), highest expression level in substantia nigra
ExpressionAtlasiE9PX28 baseline and differential
GenevisibleiE9PX28 MM

Structurei

3D structure databases

ProteinModelPortaliE9PX28
SMRiE9PX28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 120CAInterPro annotationAdd BLAST87
Domaini144 – 248CAInterPro annotationAdd BLAST105
Domaini272 – 356CAInterPro annotationAdd BLAST85
Domaini380 – 461CAInterPro annotationAdd BLAST82
Domaini485 – 572CAInterPro annotationAdd BLAST88
Domaini603 – 686CAInterPro annotationAdd BLAST84

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030712 Protocadherin-10
PANTHERiPTHR24028:SF0 PTHR24028:SF0, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PX28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVLLFFALL WMVDGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA
60 70 80 90 100
RRFQTVANSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE
110 120 130 140 150
NPLELFRVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD
160 170 180 190 200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV
210 220 230 240 250
LTAVDGGGGG GGGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF
260 270 280 290 300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
310 320 330 340 350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD
360 370 380 390 400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD
410 420 430 440 450
VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ
460 470 480 490 500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAKLTY
510 520 530 540 550
SILECQIQGM SVFTYVSINS DNGYLYALRS FDYEQIKDFS FQVEARDAGS
560 570 580 590 600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
610 620 630 640 650
TRVAAVDADD GENARLTYSI VRGNEMNLFR LDWRTGELRT ARRVPAKRDP
660 670 680 690 700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG DRGGGSGEHL
710 720 730 740 750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT
760 770 780 790 800
CLASDCCLCC CCCGNGSSTC CGRQARARKK KLSKSDIMLV QSANVPSNPA
810 820 830 840 850
QVPVEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDAEH
860 870 880 890 900
NPCGAIVTGY SDQQPDIISN GSILSNENKH QRAELSYLVD RPRRVNSSAF
910 920 930 940 950
QEADIVSSKD SGHGDSEQGD SDHDVTNRGQ SAGMDLFSNC TEECKALGHS
960 970 980 990 1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFEPP EVQPGAERSF
1010 1020 1030 1040
STFGKEKALH GTLERKELDG LLSNTRAPYK PPYLNHFHPL SCFAHWK
Length:1,047
Mass (Da):113,993
Last modified:April 5, 2011 - v1
Checksum:i338378F1AB304303
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q925I8Q925I8_MOUSE
OL-protocadherin isoform
Pcdh10 Pcadh10
1,040Annotation score:
E9PXQ7E9PXQ7_MOUSE
Protocadherin 10
Pcdh10
1,057Annotation score:
Q6P0A6Q6P0A6_MOUSE
Protocadherin 10
Pcdh10
896Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108393 Genomic DNA No translation available.
RefSeqiNP_001091642.1, NM_001098172.1
UniGeneiMm.242644

Genome annotation databases

EnsembliENSMUST00000171554; ENSMUSP00000131600; ENSMUSG00000049100
GeneIDi18526
UCSCiuc008pcy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108393 Genomic DNA No translation available.
RefSeqiNP_001091642.1, NM_001098172.1
UniGeneiMm.242644

3D structure databases

ProteinModelPortaliE9PX28
SMRiE9PX28
ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiE9PX28

Proteomic databases

MaxQBiE9PX28
PeptideAtlasiE9PX28
PRIDEiE9PX28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171554; ENSMUSP00000131600; ENSMUSG00000049100
GeneIDi18526
UCSCiuc008pcy.1 mouse

Organism-specific databases

CTDi57575
MGIiMGI:1338042 Pcdh10

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049100 Expressed in 146 organ(s), highest expression level in substantia nigra
ExpressionAtlasiE9PX28 baseline and differential
GenevisibleiE9PX28 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030712 Protocadherin-10
PANTHERiPTHR24028:SF0 PTHR24028:SF0, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PX28_MOUSE
AccessioniPrimary (citable) accession number: E9PX28
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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