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UniProtKB - E9PWW9 (E9PWW9_MOUSE)
Protein
Submitted name:
Remodeling and spacing factor 1
Gene
Rsf1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- histone binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- chromatin assembly Source: MGI
- chromatin remodeling Source: MGI
- DNA-templated transcription, initiation Source: MGI
- negative regulation of DNA binding Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- nucleosome assembly Source: MGI
- nucleosome positioning Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of viral transcription Source: MGI
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere |
Names & Taxonomyi
Protein namesi | Submitted name: Remodeling and spacing factor 1 |
Gene namesi | Name:Rsf1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2682305, Rsf1 |
VEuPathDBi | HostDB:ENSMUSG00000035623 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- RSF complex Source: MGI
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
EPDi | E9PWW9 |
jPOSTi | E9PWW9 |
PaxDbi | E9PWW9 |
PeptideAtlasi | E9PWW9 |
PRIDEi | E9PWW9 |
ProteomicsDBi | 314599 |
PTM databases
PhosphoSitePlusi | E9PWW9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035623, Expressed in manus and 271 other tissues |
Interactioni
GO - Molecular functioni
- histone binding Source: MGI
Protein-protein interaction databases
ComplexPortali | CPX-463, RSF complex |
STRINGi | 10090.ENSMUSP00000037409 |
Miscellaneous databases
RNActi | E9PWW9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 894 – 944 | PHD-typeInterPro annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 220 – 288 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 340 – 365 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 503 – 522 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 531 – 896 | DisorderedSequence analysisAdd BLAST | 366 | |
Regioni | 988 – 1012 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1066 – 1424 | DisorderedSequence analysisAdd BLAST | 359 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 947 – 970 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 264 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 569 – 609 | Basic and acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 670 – 684 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 726 – 777 | Basic and acidic residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 793 – 810 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 817 – 839 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 857 – 879 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 992 – 1012 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1066 – 1080 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1100 – 1114 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1123 – 1141 | Acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1153 – 1170 | Basic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1178 – 1199 | Acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1217 – 1236 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1245 – 1285 | Basic and acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 1294 – 1321 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1339 – 1357 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1386 – 1410 | Polar residuesSequence analysisAdd BLAST | 25 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | ENOG502QW8S, Eukaryota |
GeneTreei | ENSGT00530000064411 |
OMAi | SCTMKVE |
OrthoDBi | 917466at2759 |
PhylomeDBi | E9PWW9 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028938, Rsf1-like IPR028942, WHIM1_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR14296, PTHR14296, 1 hit |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF15612, WHIM1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9PWW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAAAAAA AAAAAMAPPG CPGSCPNFAV VCSFLERYGP LLDLPELPFP
60 70 80 90 100
ELERVLQAPP PDIGNGEVPK ELVELHLKLM RKIGKSVTAD RWEKYLIKIC
110 120 130 140 150
QEFNSTWAWE MEKKGYLEMS VECKLALLKY LCECQFDDNL KFKNIINEED
160 170 180 190 200
ADTMRLQPIG RDKDGLMYWY QLDQDHNVRM YIEEQDDQDG SSWKCIVRNR
210 220 230 240 250
NELAETLALL KAQIDPVLLK NSSQQEDSSR ESPTLEDEET KKDEETPKQE
260 270 280 290 300
ASKENEKTGA DERSVDSGKC SAASALEEPA VKTEKADEKE LAKLPVIVKL
310 320 330 340 350
EKPLPETEEK KIIREESDSF KENVKPIKVE AKECRADPKD LKGSLERLGS
360 370 380 390 400
QEPERADFGS NIKSQDIIEK STEETEKLKN DQQAKIPLKK REIKLSDDFD
410 420 430 440 450
SPVKGPLCKS ATPTKEVLKD DIKQEEETCK RVSTISALSH EGKQLVNGEI
460 470 480 490 500
NDDKVIPNFK TEQMEIQLCD TKEDSASIPA KDGNACMEGN GTECLNSVIT
510 520 530 540 550
STKTSELEKE APLGKGIDSS VPDIESLSQK ARLEEPGLLN MDMPLEPSEK
560 570 580 590 600
ATDLSLKPTL SATEPCSTKV EEKAPRSKSE NHTPGIECLE RVEKAKKTSI
610 620 630 640 650
DKDIQKLSPI PEEVVRGALE SEKSGPCEVA ETPLPLSMAG AKEKQTSEKK
660 670 680 690 700
DVDCSRGSSE SQSLENASPE ILKEDSESSR EEVAKLDNAQ TSGMEDTSET
710 720 730 740 750
KGSVQKNKFK YKLVSERNST ASENTEITSE RKKEGIKLTI RISSRKKKPD
760 770 780 790 800
CPPQTVDSES KEEKAGKEEE KASVGRTLRR SPRISRPTAK VAEIRVQKAD
810 820 830 840 850
KRRADGEDGV EGEPASLQTA DKKDHLKKAE KDTNSKASKV KPKGKVRWTG
860 870 880 890 900
SRTRGRWKYS SNDESEGSES DKSSAALEEE EGKEGEEAVL PDDDEPCKKC
910 920 930 940 950
GLPNHPELIL LCDSCDSGYH TACLRPPLMI IPDGEWFCPP CQHKLLCEKL
960 970 980 990 1000
EEQLQDLDVA LKKKERAERR KERLVYVGIS IENIIPPQEP EFSEEQEEKK
1010 1020 1030 1040 1050
KDAKKSKANA LERRSTRTRK CISYRFDEFD EAIDEAIEDD IKEADGGGVG
1060 1070 1080 1090 1100
RGKDISTITG HRGKDISTIL DEERKENKRP QRAAAARRKK RRRLNDLDSD
1110 1120 1130 1140 1150
SNLDEEESED EFKISDGSQD EFVVSDENPD ESEEEPPSNE DSDTDFCSRR
1160 1170 1180 1190 1200
LRRHPSRPMR QSRRLRRKTP KKKYSDDDEE EEESEENSRD SESDFSDDFS
1210 1220 1230 1240 1250
DDFVETRRRR SRRNQKRQIN YKEDSESDGS QKSLRRGKEI RRVHKRRLSS
1260 1270 1280 1290 1300
SESEESFMSK NSEDDELTKE SKRSVRKRGR STDDYSEADE DDEEEGKPSR
1310 1320 1330 1340 1350
KRLHRIETDE ESCDNAHGDA DQPARDSQPS ALPSEQESSK KPYRIESDEE
1360 1370 1380 1390 1400
EDFENKVGSP LDYSLVDLPS TNGQSPGKAI ENLMGKATEK SQTPKDNGTA
1410 1420 1430 1440
SASLAPNGTS GGQEVGAPEE DEDELLRVTD LVDYVCNSEQ L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RP31 | A0A0U1RP31_MOUSE | Remodeling and spacing factor 1 | Rsf1 | 121 | Annotation score: | ||
A0A0U1RPA7 | A0A0U1RPA7_MOUSE | Remodeling and spacing factor 1 | Rsf1 | 109 | Annotation score: | ||
A0A0U1RNQ5 | A0A0U1RNQ5_MOUSE | Remodeling and spacing factor 1 | Rsf1 | 14 | Annotation score: |
Sequence databases
RefSeqi | NP_001074736.1, NM_001081267.2 |
Genome annotation databases
Ensembli | ENSMUST00000107153.3; ENSMUSP00000102771.3; ENSMUSG00000035623.15 |
GeneIDi | 233532 |
KEGGi | mmu:233532 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001074736.1, NM_001081267.2 |
3D structure databases
AlphaFoldDBi | E9PWW9 |
SMRi | E9PWW9 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-463, RSF complex |
STRINGi | 10090.ENSMUSP00000037409 |
PTM databases
PhosphoSitePlusi | E9PWW9 |
Proteomic databases
EPDi | E9PWW9 |
jPOSTi | E9PWW9 |
PaxDbi | E9PWW9 |
PeptideAtlasi | E9PWW9 |
PRIDEi | E9PWW9 |
ProteomicsDBi | 314599 |
Protocols and materials databases
Antibodypediai | 31265, 124 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENSMUST00000107153.3; ENSMUSP00000102771.3; ENSMUSG00000035623.15 |
GeneIDi | 233532 |
KEGGi | mmu:233532 |
Organism-specific databases
CTDi | 51773 |
MGIi | MGI:2682305, Rsf1 |
VEuPathDBi | HostDB:ENSMUSG00000035623 |
Phylogenomic databases
eggNOGi | ENOG502QW8S, Eukaryota |
GeneTreei | ENSGT00530000064411 |
OMAi | SCTMKVE |
OrthoDBi | 917466at2759 |
PhylomeDBi | E9PWW9 |
Enzyme and pathway databases
Reactomei | R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere |
Miscellaneous databases
BioGRID-ORCSi | 233532, 10 hits in 76 CRISPR screens |
ChiTaRSi | Rsf1, mouse |
RNActi | E9PWW9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035623, Expressed in manus and 271 other tissues |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028938, Rsf1-like IPR028942, WHIM1_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR14296, PTHR14296, 1 hit |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF15612, WHIM1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PWW9_MOUSE | |
Accessioni | E9PWW9Primary (citable) accession number: E9PWW9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | February 17, 2016 | |
Last modified: | May 25, 2022 | |
This is version 83 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |