UniProtKB - E9PWW9 (E9PWW9_MOUSE)

BLAST

>tr|E9PWW9|E9PWW9_MOUSE Remodeling and spacing factor 1 OS=Mus musculus OX=10090 GN=Rsf1 PE=1 SV=2
MAAAAAAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPP
PDIGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMS
VECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRM
YIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQEDSSRESPTLEDEET
KKDEETPKQEASKENEKTGADERSVDSGKCSAASALEEPAVKTEKADEKELAKLPVIVKL
EKPLPETEEKKIIREESDSFKENVKPIKVEAKECRADPKDLKGSLERLGSQEPERADFGS
NIKSQDIIEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSATPTKEVLKD
DIKQEEETCKRVSTISALSHEGKQLVNGEINDDKVIPNFKTEQMEIQLCDTKEDSASIPA
KDGNACMEGNGTECLNSVITSTKTSELEKEAPLGKGIDSSVPDIESLSQKARLEEPGLLN
MDMPLEPSEKATDLSLKPTLSATEPCSTKVEEKAPRSKSENHTPGIECLERVEKAKKTSI
DKDIQKLSPIPEEVVRGALESEKSGPCEVAETPLPLSMAGAKEKQTSEKKDVDCSRGSSE
SQSLENASPEILKEDSESSREEVAKLDNAQTSGMEDTSETKGSVQKNKFKYKLVSERNST
ASENTEITSERKKEGIKLTIRISSRKKKPDCPPQTVDSESKEEKAGKEEEKASVGRTLRR
SPRISRPTAKVAEIRVQKADKRRADGEDGVEGEPASLQTADKKDHLKKAEKDTNSKASKV
KPKGKVRWTGSRTRGRWKYSSNDESEGSESDKSSAALEEEEGKEGEEAVLPDDDEPCKKC
GLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVA
LKKKERAERRKERLVYVGISIENIIPPQEPEFSEEQEEKKKDAKKSKANALERRSTRTRK
CISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRP
QRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEEPPSNE
DSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEEESEENSRDSESDFSDDFS
DDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESFMSK
NSEDDELTKESKRSVRKRGRSTDDYSEADEDDEEEGKPSRKRLHRIETDEESCDNAHGDA
DQPARDSQPSALPSEQESSKKPYRIESDEEEDFENKVGSPLDYSLVDLPSTNGQSPGKAI
ENLMGKATEKSQTPKDNGTASASLAPNGTSGGQEVGAPEEDEDELLRVTDLVDYVCNSEQ
L

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History
Entry version 64 (07 Nov 2018)
Sequence version 2 (17 Feb 2016)
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Protein

Submitted name:

Remodeling and spacing factor 1

Gene

Rsf1

Organism

Mus musculus (Mouse)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

histone acetyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone binding Source: MGI
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin remodeling Source: MGI
DNA-templated transcription, initiation Source: MGI
negative regulation of DNA binding Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
nucleosome assembly Source: MGI
nucleosome positioning Source: MGI
positive regulation of transcription, DNA-templated Source: MGI
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of viral transcription Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Reactomeⁱ

R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Remodeling and spacing factor 1Imported
Gene namesⁱ	Name:Rsf1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2682305 Rsf1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	E9PWW9
PeptideAtlas More...PeptideAtlasⁱ	E9PWW9
PRIDEⁱ	E9PWW9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000035623 Expressed in 249 organ(s), highest expression level in manus
ExpressionAtlasⁱ	E9PWW9 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

histone binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-463 RSF complex
STRINGⁱ	10090.ENSMUSP00000037409

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E9PWW9
SMRⁱ	E9PWW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	894 – 944	PHD-typeInterPro annotationAdd BLAST		51

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	947 – 970	Sequence analysisAdd BLAST		24
Coiled coilⁱ	993 – 1014	Sequence analysisAdd BLAST		22

Keywords - Domainⁱ

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IFYI Eukaryota ENOG410YTDT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064411
KEGG Orthology (KO) More...KOⁱ	K11657
OMAⁱ	RQINYKE

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028938 Rsf-1 IPR028942 WHIM1_dom IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10615:SF156 PTHR10615:SF156, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00628 PHD, 1 hit PF15612 WHIM1, 1 hit
SMARTⁱ	View protein in SMART SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

E9PWW9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAAAAAAA AAAAAMAPPG CPGSCPNFAV VCSFLERYGP LLDLPELPFP 
        60         70         80         90        100
ELERVLQAPP PDIGNGEVPK ELVELHLKLM RKIGKSVTAD RWEKYLIKIC 
       110        120        130        140        150
QEFNSTWAWE MEKKGYLEMS VECKLALLKY LCECQFDDNL KFKNIINEED 
       160        170        180        190        200
ADTMRLQPIG RDKDGLMYWY QLDQDHNVRM YIEEQDDQDG SSWKCIVRNR 
       210        220        230        240        250
NELAETLALL KAQIDPVLLK NSSQQEDSSR ESPTLEDEET KKDEETPKQE 
       260        270        280        290        300
ASKENEKTGA DERSVDSGKC SAASALEEPA VKTEKADEKE LAKLPVIVKL 
       310        320        330        340        350
EKPLPETEEK KIIREESDSF KENVKPIKVE AKECRADPKD LKGSLERLGS 
       360        370        380        390        400
QEPERADFGS NIKSQDIIEK STEETEKLKN DQQAKIPLKK REIKLSDDFD 
       410        420        430        440        450
SPVKGPLCKS ATPTKEVLKD DIKQEEETCK RVSTISALSH EGKQLVNGEI 
       460        470        480        490        500
NDDKVIPNFK TEQMEIQLCD TKEDSASIPA KDGNACMEGN GTECLNSVIT 
       510        520        530        540        550
STKTSELEKE APLGKGIDSS VPDIESLSQK ARLEEPGLLN MDMPLEPSEK 
       560        570        580        590        600
ATDLSLKPTL SATEPCSTKV EEKAPRSKSE NHTPGIECLE RVEKAKKTSI 
       610        620        630        640        650
DKDIQKLSPI PEEVVRGALE SEKSGPCEVA ETPLPLSMAG AKEKQTSEKK 
       660        670        680        690        700
DVDCSRGSSE SQSLENASPE ILKEDSESSR EEVAKLDNAQ TSGMEDTSET 
       710        720        730        740        750
KGSVQKNKFK YKLVSERNST ASENTEITSE RKKEGIKLTI RISSRKKKPD 
       760        770        780        790        800
CPPQTVDSES KEEKAGKEEE KASVGRTLRR SPRISRPTAK VAEIRVQKAD 
       810        820        830        840        850
KRRADGEDGV EGEPASLQTA DKKDHLKKAE KDTNSKASKV KPKGKVRWTG 
       860        870        880        890        900
SRTRGRWKYS SNDESEGSES DKSSAALEEE EGKEGEEAVL PDDDEPCKKC 
       910        920        930        940        950
GLPNHPELIL LCDSCDSGYH TACLRPPLMI IPDGEWFCPP CQHKLLCEKL 
       960        970        980        990       1000
EEQLQDLDVA LKKKERAERR KERLVYVGIS IENIIPPQEP EFSEEQEEKK 
      1010       1020       1030       1040       1050
KDAKKSKANA LERRSTRTRK CISYRFDEFD EAIDEAIEDD IKEADGGGVG 
      1060       1070       1080       1090       1100
RGKDISTITG HRGKDISTIL DEERKENKRP QRAAAARRKK RRRLNDLDSD 
      1110       1120       1130       1140       1150
SNLDEEESED EFKISDGSQD EFVVSDENPD ESEEEPPSNE DSDTDFCSRR 
      1160       1170       1180       1190       1200
LRRHPSRPMR QSRRLRRKTP KKKYSDDDEE EEESEENSRD SESDFSDDFS 
      1210       1220       1230       1240       1250
DDFVETRRRR SRRNQKRQIN YKEDSESDGS QKSLRRGKEI RRVHKRRLSS 
      1260       1270       1280       1290       1300
SESEESFMSK NSEDDELTKE SKRSVRKRGR STDDYSEADE DDEEEGKPSR 
      1310       1320       1330       1340       1350
KRLHRIETDE ESCDNAHGDA DQPARDSQPS ALPSEQESSK KPYRIESDEE 
      1360       1370       1380       1390       1400
EDFENKVGSP LDYSLVDLPS TNGQSPGKAI ENLMGKATEK SQTPKDNGTA 
      1410       1420       1430       1440 
SASLAPNGTS GGQEVGAPEE DEDELLRVTD LVDYVCNSEQ L

Length:1,441

Mass (Da):161,750

Last modified:February 17, 2016 - v2

Checksum:ⁱ6F5B28E3B7976E9A

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RP31	A0A0U1RP31_MOUSE	Remodeling and spacing factor 1 Remodeling and spacing factor 1	Rsf1	121	Annotation score:
A0A0U1RPA7	A0A0U1RPA7_MOUSE	Remodeling and spacing factor 1 Remodeling and spacing factor 1	Rsf1	109	Annotation score:
A0A0U1RNQ5	A0A0U1RNQ5_MOUSE	Remodeling and spacing factor 1 Remodeling and spacing factor 1	Rsf1	14	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124541 Genomic DNA No translation available. AC149605 Genomic DNA No translation available. AC151477 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001074736.1, NM_001081267.2
UniGeneⁱ	Mm.43977 Mm.479833

Genome annotation databases

Ensemblⁱ	ENSMUST00000107153; ENSMUSP00000102771; ENSMUSG00000035623
GeneIDⁱ	233532
KEGGⁱ	mmu:233532

Protein	Similar proteins		Species	Score	Length	Source
E9PWW9	Uncharacterized protein (Fragment)		MOUSE		980	UniRef100_E9PWW9

Protein	Similar proteins		Species	Score	Length	Source
E9PWW9	Uncharacterized protein (Fragment)		MOUSE		980	UniRef90_E9PWW9
Remodeling and spacing factor 1		RAT		1298
UPI000A310DEF		MUSPA		1446
UPI000A316704		MUSCR		1444
UPI00001CE950		RAT		1448
+1

Protein	Similar proteins		Species	Score	Length	Source
E9PWW9	Remodeling and spacing factor 1		HUMAN		1441	UniRef50_Q96T23
RSF1 isoform 11 (Fragment)		PONAB		276
RSF1 isoform 4 (Fragment)		PANTR		276
Uncharacterized protein		MACMU		1441
Remodeling and spacing factor 1		LOXAF		1441
+349

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124541 Genomic DNA No translation available. AC149605 Genomic DNA No translation available. AC151477 Genomic DNA No translation available.
RefSeqⁱ	NP_001074736.1, NM_001081267.2
UniGeneⁱ	Mm.43977 Mm.479833

3D structure databases

ProteinModelPortalⁱ	E9PWW9
SMRⁱ	E9PWW9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-463 RSF complex
STRINGⁱ	10090.ENSMUSP00000037409

Proteomic databases

PaxDbⁱ	E9PWW9
PeptideAtlasⁱ	E9PWW9
PRIDEⁱ	E9PWW9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000107153; ENSMUSP00000102771; ENSMUSG00000035623
GeneIDⁱ	233532
KEGGⁱ	mmu:233532

Organism-specific databases

CTDⁱ	51773
MGIⁱ	MGI:2682305 Rsf1

Phylogenomic databases

eggNOGⁱ	ENOG410IFYI Eukaryota ENOG410YTDT LUCA
GeneTreeⁱ	ENSGT00530000064411
KOⁱ	K11657
OMAⁱ	RQINYKE

Enzyme and pathway databases

Reactomeⁱ	R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Reactomeⁱ

R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035623 Expressed in 249 organ(s), highest expression level in manus
ExpressionAtlasⁱ	E9PWW9 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028938 Rsf-1 IPR028942 WHIM1_dom IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10615:SF156 PTHR10615:SF156, 1 hit
Pfamⁱ	View protein in Pfam PF00628 PHD, 1 hit PF15612 WHIM1, 1 hit
SMARTⁱ	View protein in SMART SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9PWW9_MOUSE
Accessionⁱ	E9PWW9Primary (citable) accession number: E9PWW9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	February 17, 2016
	Last modified:	November 7, 2018
	This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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Supporting data

UniProtKB - E9PWW9 (E9PWW9_MOUSE)

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Remodeling and spacing factor 1

Rsf1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ