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UniProtKB - E9PWW9 (E9PWW9_MOUSE)

Protein
Submitted name:

Remodeling and spacing factor 1

Gene

Rsf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone acetyltransferase activity Source: GO_Central
  • histone binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Remodeling and spacing factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rsf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2682305 Rsf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9PWW9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9PWW9

PeptideAtlas

More...PeptideAtlasi		E9PWW9

PRoteomics IDEntifications database

More...PRIDEi		E9PWW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000035623 Expressed in 249 organ(s), highest expression level in manus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9PWW9 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-463 RSF complex

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000037409

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		E9PWW9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9PWW9

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini894 – 944PHD-typeInterPro annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili947 – 970Sequence analysisAdd BLAST24
Coiled coili993 – 1014Sequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFYI Eukaryota
ENOG410YTDT LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064411

KEGG Orthology (KO)

More...KOi		K11657

Identification of Orthologs from Complete Genome Data

More...OMAi		RQINYKE

Database of Orthologous Groups

More...OrthoDBi		917466at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028938 Rsf-1
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR10615:SF156 PTHR10615:SF156, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PWW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAAAAA AAAAAMAPPG CPGSCPNFAV VCSFLERYGP LLDLPELPFP 
        60         70         80         90        100
ELERVLQAPP PDIGNGEVPK ELVELHLKLM RKIGKSVTAD RWEKYLIKIC 
       110        120        130        140        150
QEFNSTWAWE MEKKGYLEMS VECKLALLKY LCECQFDDNL KFKNIINEED 
       160        170        180        190        200
ADTMRLQPIG RDKDGLMYWY QLDQDHNVRM YIEEQDDQDG SSWKCIVRNR 
       210        220        230        240        250
NELAETLALL KAQIDPVLLK NSSQQEDSSR ESPTLEDEET KKDEETPKQE 
       260        270        280        290        300
ASKENEKTGA DERSVDSGKC SAASALEEPA VKTEKADEKE LAKLPVIVKL 
       310        320        330        340        350
EKPLPETEEK KIIREESDSF KENVKPIKVE AKECRADPKD LKGSLERLGS 
       360        370        380        390        400
QEPERADFGS NIKSQDIIEK STEETEKLKN DQQAKIPLKK REIKLSDDFD 
       410        420        430        440        450
SPVKGPLCKS ATPTKEVLKD DIKQEEETCK RVSTISALSH EGKQLVNGEI 
       460        470        480        490        500
NDDKVIPNFK TEQMEIQLCD TKEDSASIPA KDGNACMEGN GTECLNSVIT 
       510        520        530        540        550
STKTSELEKE APLGKGIDSS VPDIESLSQK ARLEEPGLLN MDMPLEPSEK 
       560        570        580        590        600
ATDLSLKPTL SATEPCSTKV EEKAPRSKSE NHTPGIECLE RVEKAKKTSI 
       610        620        630        640        650
DKDIQKLSPI PEEVVRGALE SEKSGPCEVA ETPLPLSMAG AKEKQTSEKK 
       660        670        680        690        700
DVDCSRGSSE SQSLENASPE ILKEDSESSR EEVAKLDNAQ TSGMEDTSET 
       710        720        730        740        750
KGSVQKNKFK YKLVSERNST ASENTEITSE RKKEGIKLTI RISSRKKKPD 
       760        770        780        790        800
CPPQTVDSES KEEKAGKEEE KASVGRTLRR SPRISRPTAK VAEIRVQKAD 
       810        820        830        840        850
KRRADGEDGV EGEPASLQTA DKKDHLKKAE KDTNSKASKV KPKGKVRWTG 
       860        870        880        890        900
SRTRGRWKYS SNDESEGSES DKSSAALEEE EGKEGEEAVL PDDDEPCKKC 
       910        920        930        940        950
GLPNHPELIL LCDSCDSGYH TACLRPPLMI IPDGEWFCPP CQHKLLCEKL 
       960        970        980        990       1000
EEQLQDLDVA LKKKERAERR KERLVYVGIS IENIIPPQEP EFSEEQEEKK 
      1010       1020       1030       1040       1050
KDAKKSKANA LERRSTRTRK CISYRFDEFD EAIDEAIEDD IKEADGGGVG 
      1060       1070       1080       1090       1100
RGKDISTITG HRGKDISTIL DEERKENKRP QRAAAARRKK RRRLNDLDSD 
      1110       1120       1130       1140       1150
SNLDEEESED EFKISDGSQD EFVVSDENPD ESEEEPPSNE DSDTDFCSRR 
      1160       1170       1180       1190       1200
LRRHPSRPMR QSRRLRRKTP KKKYSDDDEE EEESEENSRD SESDFSDDFS 
      1210       1220       1230       1240       1250
DDFVETRRRR SRRNQKRQIN YKEDSESDGS QKSLRRGKEI RRVHKRRLSS 
      1260       1270       1280       1290       1300
SESEESFMSK NSEDDELTKE SKRSVRKRGR STDDYSEADE DDEEEGKPSR 
      1310       1320       1330       1340       1350
KRLHRIETDE ESCDNAHGDA DQPARDSQPS ALPSEQESSK KPYRIESDEE 
      1360       1370       1380       1390       1400
EDFENKVGSP LDYSLVDLPS TNGQSPGKAI ENLMGKATEK SQTPKDNGTA 
      1410       1420       1430       1440 
SASLAPNGTS GGQEVGAPEE DEDELLRVTD LVDYVCNSEQ L
Length:1,441
Mass (Da):161,750
Last modified:February 17, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F5B28E3B7976E9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RP31A0A0U1RP31_MOUSE
Remodeling and spacing factor 1
Rsf1
121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPA7A0A0U1RPA7_MOUSE
Remodeling and spacing factor 1
Rsf1
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNQ5A0A0U1RNQ5_MOUSE
Remodeling and spacing factor 1
Rsf1
14Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC124541 Genomic DNA No translation available.
AC149605 Genomic DNA No translation available.
AC151477 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001074736.1, NM_001081267.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.43977
Mm.479833

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000107153; ENSMUSP00000102771; ENSMUSG00000035623

Database of genes from NCBI RefSeq genomes

More...GeneIDi		233532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:233532

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124541 Genomic DNA No translation available.
AC149605 Genomic DNA No translation available.
AC151477 Genomic DNA No translation available.
RefSeqiNP_001074736.1, NM_001081267.2
UniGeneiMm.43977
Mm.479833

3D structure databases

ProteinModelPortaliE9PWW9
SMRiE9PWW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-463 RSF complex
STRINGi10090.ENSMUSP00000037409

Proteomic databases

jPOSTiE9PWW9
PaxDbiE9PWW9
PeptideAtlasiE9PWW9
PRIDEiE9PWW9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107153; ENSMUSP00000102771; ENSMUSG00000035623
GeneIDi233532
KEGGimmu:233532

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51773
MGIiMGI:2682305 Rsf1

Phylogenomic databases

eggNOGiENOG410IFYI Eukaryota
ENOG410YTDT LUCA
GeneTreeiENSGT00530000064411
KOiK11657
OMAiRQINYKE
OrthoDBi917466at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000035623 Expressed in 249 organ(s), highest expression level in manus
ExpressionAtlasiE9PWW9 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028938 Rsf-1
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10615:SF156 PTHR10615:SF156, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PWW9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PWW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 17, 2016
Last modified: January 16, 2019
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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