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Entry version 81 (10 Feb 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Zonadhesin

Gene

Zan

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ZonadhesinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZanImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106656, Zan

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5355 – 5381HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509035618 – 5420Sequence analysisAdd BLAST5403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi5329 ↔ 5338PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E9PWQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079173, Expressed in cardiac ventricle and 65 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 210MAMInterPro annotationAdd BLAST166
Domaini215 – 374MAMInterPro annotationAdd BLAST160
Domaini377 – 542MAMInterPro annotationAdd BLAST166
Domaini1325 – 1544VWFDInterPro annotationAdd BLAST220
Domaini1714 – 1931VWFDInterPro annotationAdd BLAST218
Domaini2101 – 2317VWFDInterPro annotationAdd BLAST217
Domaini4908 – 5109VWFDInterPro annotationAdd BLAST202
Domaini5303 – 5339EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni552 – 579DisorderedSequence analysisAdd BLAST28
Regioni972 – 991DisorderedSequence analysisAdd BLAST20
Regioni1004 – 1024DisorderedSequence analysisAdd BLAST21
Regioni1061 – 1157DisorderedSequence analysisAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi563 – 579PolarSequence analysisAdd BLAST17
Compositional biasi1005 – 1024PolarSequence analysisAdd BLAST20
Compositional biasi1061 – 1081PolarSequence analysisAdd BLAST21
Compositional biasi1092 – 1128PolarSequence analysisAdd BLAST37
Compositional biasi1143 – 1157PolarSequence analysisAdd BLAST15

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_223187_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCNHPCK

Database of Orthologous Groups

More...
OrthoDBi
22053at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263, MAM, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR003645, Fol_N
IPR000998, MAM_dom
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00629, MAM, 3 hits
PF01826, TIL, 25 hits
PF12714, TILa, 25 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00181, EGF, 15 hits
SM00274, FOLN, 20 hits
SM00137, MAM, 3 hits
SM00214, VWC, 24 hits
SM00215, VWC_out, 14 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 3 hits
SSF57567, SSF57567, 25 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 3 hits
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PWQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPVWTLML LVGAAWGQEQ VPAWRPNSPD LGPMVHTSRE DSILSKCDFE
60 70 80 90 100
DNSRPFCDWS QMSADDGDWI RTTGPSLTGT SGPPGGYPNG EGYYLHMDPK
110 120 130 140 150
TFPQGGVARL RSPDIWEQGP LCVHFAFHMF GLSWGAQLRL LLLRGRKHLR
160 170 180 190 200
PYVLWKHVNT QSPSWMPTTV TVPADHDIPS WLMFEGMRGN TAYLDISLDG
210 220 230 240 250
LSIQRGTCNQ VCMSQMCTFD TLNDLCGWSW VPTATGAKWT QKKGPTGKQG
260 270 280 290 300
VGPAEDFSNP GNGYYMLLDS TNARPGQKAV LLSPLSHSRG CMTLSFHYIM
310 320 330 340 350
HGQGHEEGLF VYATFLGNIR KYTLFSGHPG PDWQAVSVNY TGQGQIQFMV
360 370 380 390 400
VGMFGNIPEP AIAVDAISIA PCGESFPQCD FEDRVHPFCD WNQVYGDMGH
410 420 430 440 450
WSWGSKSVPT LIAGSPREFP YGGEHYIFFD SVKLSQEGQS ARLVSPPFCA
460 470 480 490 500
PGDICVEFAY HMYGLGKGTT LKLLLGSPAG SFPIPLWNRV GSQSSGWMNS
510 520 530 540 550
SVTIPKGYQQ PMQLFIEATR GTSTAFVVAL NFILISHGPC RVLLQTEIPS
560 570 580 590 600
SPLLPPTGPS ESTVPTLPME QPTSPTKATT VTIEIPTTPT EEATIPTETT
610 620 630 640 650
TVPTEVINVS PKETSIPPEV TIPTEVITVS PEEIISPTEV TPVPTDVTAA
660 670 680 690 700
YVEATNASPE ETSVPPEVTI LTEVTTVSPE ETTVPTEVPI VLIEATAFPT
710 720 730 740 750
GETTLYTEVP TVPTEVTGVH TEVTNVSPEE TSVPTEETIS TEVTTVSPEE
760 770 780 790 800
TTLPTEVPTV STEVTNVSPE ETSVPPEETI LTTLYTEVPT VPTEVTGVHT
810 820 830 840 850
EVTNVSPEET SVPTEETIST EVTTVSPEET TLPTEVPTVS TEVTNVSPEE
860 870 880 890 900
TSVPPEETIL TEITTVSPEE TVFPIEGTTL PTEVLTVPIE VTTFPTGETT
910 920 930 940 950
VPTEVPTVST EMTGVHTEVT TVFPEETSIP TEVATVLPAS IPPEETTTPT
960 970 980 990 1000
EVTTTPPEET TIPAEVTTIP PVSIPSEETT TPTEVTTTPP EETTIPAEVT
1010 1020 1030 1040 1050
TVPPVSIPSE ETTTPTEVTT TPPEETTIPA EVTTVPPVSI PSEETTIPTE
1060 1070 1080 1090 1100
VTTVPPEETT IPAEVTTTPP EETTIPTEVT TVPPASIPPE ETASLTEVTT
1110 1120 1130 1140 1150
TPPEETTTPT EVTTVPPEKT TIPTEVTTVP PASIFPEETT VPPEETTIAS
1160 1170 1180 1190 1200
EETTVSTQET TLLTEQSAVT QTSIACRPPC PSPPLMPIGP LLSKPPGVSM
1210 1220 1230 1240 1250
FSLAPTTGVS TTESCPPNAH IELCACPASC ESPKPSCQPP CIPGCVCNPG
1260 1270 1280 1290 1300
FLFSNNQCIN ESSCNCPYNN KYYKPGEEWF TPNCTERCRC LPGSLMECQI
1310 1320 1330 1340 1350
SQCGTHTVCQ LKSDQYQCEP YGKATCLVYG DLHFVTFDER HIGFTGTCTY
1360 1370 1380 1390 1400
ILTQTCSNST DHFFRITANT EERGVEGVSC LDKVVISLPE TTVTMISGRH
1410 1420 1430 1440 1450
TLIGDQEVTL PAILSDDTYV GLSGRFVELR TTFGLRVRWD GDQQLFVTVS
1460 1470 1480 1490 1500
STFSGKLCGF CGNYDGDSSN DNLKSDGMMT HDEEELRLSW QVEEDEDKDW
1510 1520 1530 1540 1550
VSSRCQKKKN PPSCDAALGS TMSGPKLCGQ LVNPSGPFEA CLLHLKASSF
1560 1570 1580 1590 1600
LDNCVTDMCS FQGLQQKLCA HMSAMTATCQ DAGYPVKPWR EPQFCPLVCP
1610 1620 1630 1640 1650
KNSRYSLCAK PCPETCHPIS TTQHCSDKCV EGCECDPGFI LSGSECVPSS
1660 1670 1680 1690 1700
QCGCTSFQGR YFKLQEQWFN PDCKEICTCE SHNHILCKPW KCKAQEACSY
1710 1720 1730 1740 1750
KNGVLGCHAQ GAATCMVSGD PHYLTFDGAL HHFMGTCTYV LTQPCWSKSQ
1760 1770 1780 1790 1800
ENNFVVSATN EIHDGNLEVS YVKAVHVQVF DLKISMFKGQ KVVLNNQRVV
1810 1820 1830 1840 1850
LPVWPSQGRV TIRLSGIFVL LYTNFGLQVR YDGRHLVEVT VPSSYTGSLC
1860 1870 1880 1890 1900
GLCGNYNNNS MDDNLRVDMK PAGNSLLLGA AWKILEASDP GCFLVGGKPS
1910 1920 1930 1940 1950
RCADSDMDDV WTKKCAILMN PLGPFSNCHE AVPPQASFSS CVYGQCETNG
1960 1970 1980 1990 2000
DNLTLCHSLQ AYASLCAQAG QVTTWRNSTF CPMRCPPRSS YNPCANSCPA
2010 2020 2030 2040 2050
TCLTLSTPRD CPTLPCVEGC ECQSGHILSG TTCVPLRQCG CSDQDGSYHL
2060 2070 2080 2090 2100
LGESWYTEKT CTTLCTCSAH SNITCSPTAC KANHVCLRQE GLLRCAAEMG
2110 2120 2130 2140 2150
ECRISEDSQI VSFDDHSHPI QDTCTYILVK VCHPNTNMPF FMISAKTDIN
2160 2170 2180 2190 2200
TNGKNKTFGV YQLYIDIFNF HITLQKDHLV LISLINDSIV TLPTTTHIPG
2210 2220 2230 2240 2250
VSVMTEDVYT IVTIKDEIQV KFESNNFLDV KIPASSNGKV CGVCGNFNGE
2260 2270 2280 2290 2300
EEDELMTPSG ELAEDEQEFM NSWKDKSMDP NCQKIEGQNL QVEQQEIMNG
2310 2320 2330 2340 2350
KCRPIDFEKA QANCQTALQG PAWAHCSSRV PIKPFLLKCM NSFCEFRELF
2360 2370 2380 2390 2400
RALCDSLQSF EDACQNQGLK PPIWRNSSFC PLECPAHSHY TNCLPSCPPS
2410 2420 2430 2440 2450
CLDPDSRCEG SGHKVPATCR EGCICQPDYV LLNDKCVLRS HCGCKDAQGV
2460 2470 2480 2490 2500
FIPAGKTWIS EDCTQSCTCM KGSMRCWDFQ CPPGTYCKNS NDGSSNCVKI
2510 2520 2530 2540 2550
SLQCPAHSKF TDCLPPCHPS CSDPDGHCEG ISTNAHSNCK EGCVCQPGYV
2560 2570 2580 2590 2600
LRNDKCVLRI ECGCQHTQGG FIPAGKSWTS RGCSQSCDCM EGVIRCQNFQ
2610 2620 2630 2640 2650
CPSGTYCQDI EDGTSNCANI TLQCPAHSSF TNCLPPCQPS CSDPEGHCGG
2660 2670 2680 2690 2700
STTKAPSACQ EGCVCEPDYV VLNNKCVPRI ECGCKDAQGV LIPADKIWIN
2710 2720 2730 2740 2750
KGCTQTCACV TGTIHCRDFQ CPSGTYCKDI KDDTSNCTEI TLQCPDHSLY
2760 2770 2780 2790 2800
THCLPSCLPS CSDPDGLCRG TSPEAPSTCK EGCVCEPDYV LSNDKCVLRI
2810 2820 2830 2840 2850
ECGCKDAQGV LIPAGKTWIN RGCTQSCSCM GGAIQCQNFK CPSEAYCQDL
2860 2870 2880 2890 2900
EDGNSNCTSI PLQCPAHSHY TNCLPTCQPS CSDPDGHCEG SSTKAPSACK
2910 2920 2930 2940 2950
EGCVCEPDYV MLNNKCVPRI ECGCKDTQGV LIPADKTWIN RGCTQSCTCK
2960 2970 2980 2990 3000
GGAIQCQKYH CSSGTYCKDM EDDSSSCATI TLQCPAHSHF TNCLPPCQPS
3010 3020 3030 3040 3050
CLDSEGHCEG STTKAPSACQ EGCVCEPDYV VLNNKCVPRI ECGCKDAQGV
3060 3070 3080 3090 3100
LIPADKTWIN RGCTQSCTCK GGAIQCQKFQ CPSETYCKDI EDGNSNCTRI
3110 3120 3130 3140 3150
SLQCPANSNF TSCLPSCQPS CSNTDVHCEG SSPNALSSCR EGCVCQSGYV
3160 3170 3180 3190 3200
LHNDKCILRN QCGCKDAQGA LIPEGKTWIT SGCTQSCNCT GGAIQCQNFQ
3210 3220 3230 3240 3250
CPLKTYCKDL KDGSSNCTNI PLQCPAHSHY TNCLPSCPPS CLDPEGLCEG
3260 3270 3280 3290 3300
TSPKVPSTCR EGCICQPGYL MHKNKCVLRI FCGCKNTQGA FISADKTWIS
3310 3320 3330 3340 3350
RGCTQSCTCS AGAIHCRNFK CPSGTYCKNG DNGSSNCTEI TLQCPTNSQF
3360 3370 3380 3390 3400
TDCLPSCVPS CSNRCEVTSP SVPSSCREGC LCNHGFVFSE DKCVPRTQCG
3410 3420 3430 3440 3450
CKDARGAIIP AGKTWTSKGC TQSCACVEGN IQCQNFQCPP ETYCKDNSEG
3460 3470 3480 3490 3500
SSTCTKITLQ CPAHTQYTSC LPSCLPSCLD PEGLCKDISP KVPSTCKEGC
3510 3520 3530 3540 3550
VCQSGYVLNS DKCVLRAECD CKDAQGALIP AGKTWTSPGC TQSCACMGGA
3560 3570 3580 3590 3600
VQCQSSQCPP GTYCKDNEDG NSNCAKITLQ CPAHSLFTNC LPSCLPSCLD
3610 3620 3630 3640 3650
PDGLCKGASP KVPSSCKEGC ICQSGYVLSN NKCLLRNRCG CKDAHGALIP
3660 3670 3680 3690 3700
EDKTWVSRGC TQSCVCTGGS IQCLSFQCPP GAYCKDNEDG SSNCARIPPQ
3710 3720 3730 3740 3750
CPANSHYTDC FPPCPPSCSD PEGHCEASGP RVPSTCREGC LCNPGFVLDR
3760 3770 3780 3790 3800
DKCVPRVECG CKDAQGALIP SGKTWTSPGC TQSCACMGGV VQCQSSQCPP
3810 3820 3830 3840 3850
GTYCKDNEDG NSNCAKITLQ CPTHSNYTDC LPFCLPSCLD PSALCGGTSP
3860 3870 3880 3890 3900
KGPSTCKEGC VCQPGYVLDK DKCILKIECG CRDTQGAVIP AGKTWLSTGC
3910 3920 3930 3940 3950
IQSCACVEGT IQCQNFQCPP GTYCNHNNNC AKIPLQCPAH SHFTSCLPSC
3960 3970 3980 3990 4000
PPSCANLDGS CEQTSPKVPS TCKEGCLCQP GYFLNNGKCV LQTHCDCKDA
4010 4020 4030 4040 4050
EGGLVPAGKT WTSKDCTQSC ACTGGAVQCQ NFQCPLGTYC KDSGDGSSNC
4060 4070 4080 4090 4100
TKIHKGAMGD GVLMAGGIRA LQCPAHSHFT SCLPSCPPSC SNLDGSCVES
4110 4120 4130 4140 4150
NFKAPSVCKK GCICQPGYLL NNDKCVLRIQ CGCKDTQGGL IPAGRTWISS
4160 4170 4180 4190 4200
DCTKSCSCMG GIIQCRDFQC PPGTYCKESN DSSRTCAKIP LQCPAHSHYT
4210 4220 4230 4240 4250
NCLPACSRSC TDLDGHCEGT SPKVPSPCKE GCLCQPGYVV HNHKCVLQIH
4260 4270 4280 4290 4300
CGCKDAQGGF VPAGKTWISR GCTQSCACVG GAVQCHNFTC PTGTQCQNSS
4310 4320 4330 4340 4350
CSKITVQCPA HSHYTTCLPS CLPSCFDPEG LCGDASPRAP PTCREGCVCE
4360 4370 4380 4390 4400
ADYVLREDKC VLRTQCGCKD AQGDLIPANK TWLTRGCAQK CTCKGGNIHC
4410 4420 4430 4440 4450
WNFKCPLGTE CKDSVDGGSN CTKIALQCPA HSHHTYCLPS CIPSCSNVND
4460 4470 4480 4490 4500
RCESTSLQRP STCIEGCLCH SGFVFSKDKC VPRTQCGCKD SQGTLIPAGK
4510 4520 4530 4540 4550
NWITTGCSQR CTCTGGLVQC HDFQCPSGAE CQDIEDGNSN CVEITVQCPA
4560 4570 4580 4590 4600
HSHYSKCLPP CQPSCSDPDG HCEGTSPEAP STCEEGCVCE PDYVLSNDKC
4610 4620 4630 4640 4650
VPSSECGCKD AHGVLIPESK TWVSRGCTKN CTCKGGTVQC HDFSCPTGSR
4660 4670 4680 4690 4700
CLDNNEGNSN CVTYALKCPA HSLYTNCLPS CLPSCSDPEG LCGGTSPEVP
4710 4720 4730 4740 4750
STCKEGCFCQ SGYVLHKNKC MLRIHCDCKD FQGSLIKTGQ TWISSGCSKI
4760 4770 4780 4790 4800
CTCKGGFFQC QSYKCPSGTQ CEESEDGSSN CVSSTMKCPA NSLYTHCLPT
4810 4820 4830 4840 4850
CLPSCSNPDG RCEGTSHKAP STCREGCVCQ PGYLLNKDTC VHKNQCGCKD
4860 4870 4880 4890 4900
IRGNIIPAGN TWISSDCTQS CACTDGVIQC QNFVCPSGSH CQYNEDGSSD
4910 4920 4930 4940 4950
CAANKLERCT IFGDPYYLTF DGFTYHFLGR MNYYLIKTVD KLPRGIEPLI
4960 4970 4980 4990 5000
MEGRNKISPK GSSTLHEVTT IVYGYKIQLQ EELVVLVNDE KVAVPYNPNE
5010 5020 5030 5040 5050
HLRVMLRAQR LLLVTDFEMV LDFDGKHSAV ISLPTTYRGL TRGLCGNYDR
5060 5070 5080 5090 5100
DQSNELMLPS GVLTSNVHVY GNSWEVKAQH AFFRFPRALP EEEERDEEPD
5110 5120 5130 5140 5150
LLQSECSQEQ TALISSTQAC RVLVDPQGPF AACHQIIAPE PFEQRCMLDM
5160 5170 5180 5190 5200
CTGWKTKEEE ELRCRVLSGY AIICQEAGAN MTGWRDHTHC AMTCPANTVY
5210 5220 5230 5240 5250
QRCMTPCPAS CAKFVTPKVC EGPCVEGCAS LPGYIYSDTQ SLPVTHCGCT
5260 5270 5280 5290 5300
ADGIYYKLGD SFVTNDCSQH CTCASQGILL CEPYGCRAGE SCMVANFTRG
5310 5320 5330 5340 5350
CFQDSPCLQN PCHNDGRCEE QGATFICHCD FGYGGEFCTE PQDITTRKKI
5360 5370 5380 5390 5400
EASSLVAILP GVLVMVLVPV LLPRVYVYMA TRTTMGRRRM KRKEKKLLRQ
5410 5420
SRLRLEDADV PEPTFKATEF
Length:5,420
Mass (Da):584,655
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2A5C7F784CBAA48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88799ZAN_MOUSE
Zonadhesin
Zan
5,376Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACV3F7ACV3_MOUSE
Zonadhesin
Zan
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC148018 Genomic DNA No translation available.
AC150682 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_035871.2, NM_011741.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000117564; ENSMUSP00000114068; ENSMUSG00000079173
ENSMUST00000164178; ENSMUSP00000132895; ENSMUSG00000079173

Database of genes from NCBI RefSeq genomes

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GeneIDi
22635

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:22635

UCSC genome browser

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UCSCi
uc012eey.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148018 Genomic DNA No translation available.
AC150682 Genomic DNA No translation available.
RefSeqiNP_035871.2, NM_011741.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiE9PWQ7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
73512, 44 antibodies

Genome annotation databases

EnsembliENSMUST00000117564; ENSMUSP00000114068; ENSMUSG00000079173
ENSMUST00000164178; ENSMUSP00000132895; ENSMUSG00000079173
GeneIDi22635
KEGGimmu:22635
UCSCiuc012eey.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7455
MGIiMGI:106656, Zan

Phylogenomic databases

GeneTreeiENSGT00940000156850
HOGENOMiCLU_223187_0_0_1
OMAiQCNHPCK
OrthoDBi22053at2759
TreeFamiTF300299

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22635, 1 hit in 18 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079173, Expressed in cardiac ventricle and 65 other tissues

Family and domain databases

CDDicd06263, MAM, 3 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR003645, Fol_N
IPR000998, MAM_dom
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR025615, TILa_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF00629, MAM, 3 hits
PF01826, TIL, 25 hits
PF12714, TILa, 25 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00181, EGF, 15 hits
SM00274, FOLN, 20 hits
SM00137, MAM, 3 hits
SM00214, VWC, 24 hits
SM00215, VWC_out, 14 hits
SM00216, VWD, 4 hits
SUPFAMiSSF49899, SSF49899, 3 hits
SSF57567, SSF57567, 25 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 3 hits
PS51233, VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PWQ7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PWQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 10, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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