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Entry version 67 (02 Jun 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

ATP-binding cassette, sub-family A (ABC1), member 16

Gene

Abca16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi546 – 553ATPPROSITE-ProRule annotation8
Nucleotide bindingi1387 – 1394ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette, sub-family A (ABC1), member 16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2388711, Abca16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei292 – 320HelicalSequence analysisAdd BLAST29
Transmembranei332 – 354HelicalSequence analysisAdd BLAST23
Transmembranei360 – 379HelicalSequence analysisAdd BLAST20
Transmembranei391 – 410HelicalSequence analysisAdd BLAST20
Transmembranei436 – 457HelicalSequence analysisAdd BLAST22
Transmembranei901 – 922HelicalSequence analysisAdd BLAST22
Transmembranei1064 – 1085HelicalSequence analysisAdd BLAST22
Transmembranei1106 – 1128HelicalSequence analysisAdd BLAST23
Transmembranei1148 – 1168HelicalSequence analysisAdd BLAST21
Transmembranei1180 – 1200HelicalSequence analysisAdd BLAST21
Transmembranei1206 – 1224HelicalSequence analysisAdd BLAST19
Transmembranei1271 – 1289HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PWJ7

PRoteomics IDEntifications database

More...
PRIDEi
E9PWJ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
316581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000051900, Expressed in spermatocyte and 18 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9PWJ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PWJ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini514 – 744ABC transporterInterPro annotationAdd BLAST231
Domaini1352 – 1585ABC transporterInterPro annotationAdd BLAST234

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163770

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PWJ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFANIDK

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229, PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PWJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQLTVNQLT VLLWKNFTLK KRQIISTSAE LLAALLFVIM LLIFRALTDM
60 70 80 90 100
NIAGPYHFTA QPIAIMPSFI KDAQEWELVY IPSEIDVVRE IIEDVKRNLN
110 120 130 140 150
TTIKVRGFPS EAEFEEYILF DNMSQKVLAA IVFDCGFKNK SDPLPLQVKY
160 170 180 190 200
HLRFVGAQRT IWWPDKLGWK TRLLFPNHPS IRPRNPNYLD GGSPGYIKEG
210 220 230 240 250
FLAVQHALDK SIMLYHESSA GKKLFDEIDT VIQRFPYPSH PQDKLLWISS
260 270 280 290 300
PFIPLMFILM FSSIVLSIMR SIVFEKEKRL KEYQLIMGLR NWIIWIGYFF
310 320 330 340 350
TFFPLYVIII LLICILLFIV EEPILRYSDC SFIFVFLTCY AIASICFAFM
360 370 380 390 400
VSTFFSKTRL AASAGNLLFF ASFFPYNFIS EYYGMLNLTT KITACLSANV
410 420 430 440 450
ALALGINILI KLEIQEIGVK WHNLWTPANL EDNLNFGYML GMLLFDAFLY
460 470 480 490 500
SLVTWYVEAV FPGQCGVPQP WYFFLMRSYW FGKPKIRKTT EEAKCTPIVH
510 520 530 540 550
NCYEAEPPNL EAGIHIMHLH KEFKNKPAVN NLSLNIYEGQ VTVLLGHNGA
560 570 580 590 600
GKTTTLSVLT GVYPYASRVK AYINGYNISD NMIEVRKDLG FCPQHDLLFD
610 620 630 640 650
DLTLSEHLFF YCMVKGIPQN INCEEIDRML SAFNLQENYH TLSGSASGGV
660 670 680 690 700
RRKLSIVLAL MAGSKVVILD EPSSGMDPVS RRATWDILQH YKHNRTILLT
710 720 730 740 750
THYMDEADVL GDRVAIMVRG TLHCCGSSVF LKQIYGAGYH IVMEKQQYCD
760 770 780 790 800
VDNIIAMIQQ HVPGAVLENN IENELSFILP KKYVSRFETL FTELEMRQKA
810 820 830 840 850
LGIASFGASI TTMEEVFVKV NKLATPQKSI QTIQPYYLAY RKMRQDEQQN
860 870 880 890 900
VNMPINYSKP NFPYLSEIAT VKFNTGVPLY RQQFYSLFIK RALFISRNWK
910 920 930 940 950
FMLLQIIVVM VVTTYLLLAL HLNNNDIPER ELNLSHYGRT IVPYSTSGNS
960 970 980 990 1000
DLALNLTKNL NIFLKSKNQN LRKIRGDMND YILKNKDCHT FCLVALSIKV
1010 1020 1030 1040 1050
ERNKTVLTIF FNNEAYHSPA ISLSILDNIL FMTLSGPDAS ITVFNKPQPL
1060 1070 1080 1090 1100
PHYGSNIVPV NGLQIVQCLA FGISVVVGSF SIQTVTERTS QAKHIQFLTG
1110 1120 1130 1140 1150
VCVHTYWLSA LLCDLIFFFF ACCVLLAIFK FCQLEAFVVH YNFLDTILIF
1160 1170 1180 1190 1200
MLYGWCVVPL TYIASFLFNS STAAYIKITL FNYFSTMFSI IIYTIIQFYG
1210 1220 1230 1240 1250
NDFPNFVHIL IRAILMALPS YNLAMSISKY FDDYEVKRLC AREFKSIYLD
1260 1270 1280 1290 1300
CSDPYTQNNV YGFGEHGIGK FLITLATIGL VFLLLLLSLE SVSCSLKSFV
1310 1320 1330 1340 1350
FRNIIFYFYN KLRKGRNAIP SNQRTKEDED EDIKKEKGKV FTLLLRLQNT
1360 1370 1380 1390 1400
PLLLNEVTKI YFKCPVVKAV KNISLVVKKS ECFGLLGLNG AGKTTTFKML
1410 1420 1430 1440 1450
TGEETITSGI AFIDGNSVTR TPRKIRSRIG YCPQTESVLN HMTGRESLVM
1460 1470 1480 1490 1500
YARLWGVLEQ DINEYVEAFL HSVHLEPIAD QFIHTYSAGS KRRLSTAIAL
1510 1520 1530 1540 1550
MGKSSVVFLD EPSIGMDPVA QHLLWETITW ICKTGKAIII TSHRMEECEA
1560 1570 1580 1590 1600
LCTRLAIMVK GRFTCLGTPQ HVRKRFGHVY TLTVRINIAK DEDKVEEFKN
1610 1620 1630 1640 1650
FIKVTFPGNI KFQEFHGTIG YYIPSKEIYW GKVFAILEEA KVLFKLEDYS
1660 1670
VKRVTLEQIF LTFANTDKMR TYQEIKLQ
Length:1,678
Mass (Da):192,268
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB039602F157C7108
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAF2E9QAF2_MOUSE
ATP-binding cassette, sub-family A ...
Abca16
1,677Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000120490; ENSMUSP00000112736; ENSMUSG00000051900

UCSC genome browser

More...
UCSCi
uc033jbx.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiE9PWJ7
ModBaseiSearch...

Proteomic databases

PaxDbiE9PWJ7
PRIDEiE9PWJ7
ProteomicsDBi316581

Genome annotation databases

EnsembliENSMUST00000120490; ENSMUSP00000112736; ENSMUSG00000051900
UCSCiuc033jbx.1, mouse

Organism-specific databases

MGIiMGI:2388711, Abca16

Phylogenomic databases

eggNOGiKOG0059, Eukaryota
GeneTreeiENSGT00940000163770
InParanoidiE9PWJ7
OMAiTFANIDK
TreeFamiTF105191

Miscellaneous databases

RNActiE9PWJ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000051900, Expressed in spermatocyte and 18 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003439, ABC_transporter-like
IPR026082, ABCA
IPR027417, P-loop_NTPase
PANTHERiPTHR19229, PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PWJ7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PWJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 2, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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