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Protein
Submitted name:

Mutated in colorectal cancers

Gene

Mcc

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi33 – 44PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mutated in colorectal cancersImported
Gene namesi
Name:MccImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:96930 Mcc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PWI3
PaxDbiE9PWI3
PeptideAtlasiE9PWI3
PRIDEiE9PWI3

Expressioni

Gene expression databases

BgeeiENSMUSG00000071856 Expressed in 240 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiE9PWI3 baseline and differential
GenevisibleiE9PWI3 MM

Interactioni

Protein-protein interaction databases

IntActiE9PWI3, 1 interactor
STRINGi10090.ENSMUSP00000087318

Structurei

3D structure databases

ProteinModelPortaliE9PWI3
SMRiE9PWI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 55EF-handInterPro annotationAdd BLAST36
Domaini56 – 88EF-handInterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili200 – 248Sequence analysisAdd BLAST49
Coiled coili257 – 305Sequence analysisAdd BLAST49
Coiled coili396 – 423Sequence analysisAdd BLAST28
Coiled coili431 – 465Sequence analysisAdd BLAST35
Coiled coili568 – 602Sequence analysisAdd BLAST35
Coiled coili748 – 768Sequence analysisAdd BLAST21
Coiled coili783 – 824Sequence analysisAdd BLAST42
Coiled coili904 – 924Sequence analysisAdd BLAST21
Coiled coili936 – 992Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IESN Eukaryota
ENOG410XQHM LUCA
GeneTreeiENSGT00530000063974
InParanoidiE9PWI3
OMAiTGCSVQP
OrthoDBiEOG091G0GQZ
PhylomeDBiE9PWI3
TreeFamiTF333056

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR019536 USH1C-bd_PDZ_domain
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF10506 MCC-bdg_PDZ, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PWI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASACNSS GGSSDTSSTG EEERLRRLFQ TCDGDGDGYI SRNDLLMVCR
60 70 80 90 100
QLSMEESVAE IMNQLGSDEN GKISFQDFTR CHTQLVREIR KEEGDLSMKS
110 120 130 140 150
DMSSTKRLSE RITSWPTSSD NSLGALSAAR ESWEDDSGAR DLQSPDLQSQ
160 170 180 190 200
RPLQKLLEYG GSSLPQQAVL HKLLTHAPNF GTSTGGSYLE LASTLHLAAL
210 220 230 240 250
ASLKGDIVEL NKRLQQTERE RDLLEKKLAK AQCEQSHLMR EHEDVQERTT
260 270 280 290 300
LRYEERITEL HSIIAELNKK IDRLQGTTIR EEDEYSELRS ELSQSQQEVN
310 320 330 340 350
EDSRSVDQDQ TSVSIPENQS TMVTADMDNC SDLNSELQRV LTGLESVVCG
360 370 380 390 400
RKKSSCSLSV ADVDRHIEQL TTASEHCDLA IKTVEEIEGV LGRDLYPNLA
410 420 430 440 450
EERSRWEKEL AGLREENESL TAMLCSKEEE LNRTKATMNA IREERDRLRR
460 470 480 490 500
RVRELQTRLQ SVQATGPSSP GRLTPANRPI NPSTGELSTS SSSNDIPIAK
510 520 530 540 550
IAERVKLSKT RSESSSSDRP VLGSEISSIG VSSSVAEHLA HSLQDCSNIQ
560 570 580 590 600
EIFQTLYSHG SAISESKIRE FEVETERLNS RIEHLKSQND LLTITLEECK
610 620 630 640 650
SNAERMSMLV GKYESNATAL RLALQYSEQC IEAYELLLAL AESEQSLILG
660 670 680 690 700
QFRAAGVGSS PGDQSGDENI TQMLKRAHDC RKTAENAAKA LLMKLDGSCG
710 720 730 740 750
GAFAVAGCSV QPWESLSSNS HTSTTSSTAS SCDTEFTKED EQRLKDYIQQ
760 770 780 790 800
LKNDRAAVKL TMLELESIHI DPLSYDVKPR GDSQRLDLEN AVLMQELMAM
810 820 830 840 850
KEEMAELKAQ LYLLEKEKKA LELKLSTREA QEQAYLVHIE HLKSEVEEQK
860 870 880 890 900
EQRTRSLSST SSSGKEKPGK ECADAASPAL SLAELRTNSD SELATEFANA
910 920 930 940 950
IRREKKLKAR VQELVSALER LTKSSEIRHQ QSAEFVNDLK RANSNLVAAY
960 970 980 990 1000
EKAKKKHQNK LKKLESQMMA MVERHETQVR MLKQRIALLE EENSRPHTNE

TSL
Length:1,003
Mass (Da):111,993
Last modified:April 5, 2011 - v1
Checksum:iFFF488F60C961AF6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UW40G3UW40_MOUSE
MCG4620, isoform CRA_b
Mcc mCG_4620
828Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124191 Genomic DNA No translation available.
AC137150 Genomic DNA No translation available.
AC147551 Genomic DNA No translation available.
RefSeqiNP_001078842.1, NM_001085373.1
UniGeneiMm.312511
Mm.427116

Genome annotation databases

EnsembliENSMUST00000089874; ENSMUSP00000087318; ENSMUSG00000071856
GeneIDi328949
KEGGimmu:328949
UCSCiuc008euz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124191 Genomic DNA No translation available.
AC137150 Genomic DNA No translation available.
AC147551 Genomic DNA No translation available.
RefSeqiNP_001078842.1, NM_001085373.1
UniGeneiMm.312511
Mm.427116

3D structure databases

ProteinModelPortaliE9PWI3
SMRiE9PWI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PWI3, 1 interactor
STRINGi10090.ENSMUSP00000087318

Proteomic databases

MaxQBiE9PWI3
PaxDbiE9PWI3
PeptideAtlasiE9PWI3
PRIDEiE9PWI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089874; ENSMUSP00000087318; ENSMUSG00000071856
GeneIDi328949
KEGGimmu:328949
UCSCiuc008euz.1 mouse

Organism-specific databases

CTDi4163
MGIiMGI:96930 Mcc

Phylogenomic databases

eggNOGiENOG410IESN Eukaryota
ENOG410XQHM LUCA
GeneTreeiENSGT00530000063974
InParanoidiE9PWI3
OMAiTGCSVQP
OrthoDBiEOG091G0GQZ
PhylomeDBiE9PWI3
TreeFamiTF333056

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071856 Expressed in 240 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiE9PWI3 baseline and differential
GenevisibleiE9PWI3 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR019536 USH1C-bd_PDZ_domain
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF10506 MCC-bdg_PDZ, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PWI3_MOUSE
AccessioniPrimary (citable) accession number: E9PWI3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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