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Protein
Submitted name:

Mutated in colorectal cancers

Gene

Mcc

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi33 – 44PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mutated in colorectal cancersImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MccImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96930 Mcc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PWI3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PWI3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PWI3

PeptideAtlas

More...
PeptideAtlasi
E9PWI3

PRoteomics IDEntifications database

More...
PRIDEi
E9PWI3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071856 Expressed in 240 organ(s), highest expression level in brain blood vessel

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PWI3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PWI3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9PWI3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000087318

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PWI3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PWI3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 55EF-handInterPro annotationAdd BLAST36
Domaini56 – 88EF-handInterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili200 – 248Sequence analysisAdd BLAST49
Coiled coili257 – 305Sequence analysisAdd BLAST49
Coiled coili396 – 423Sequence analysisAdd BLAST28
Coiled coili431 – 465Sequence analysisAdd BLAST35
Coiled coili568 – 602Sequence analysisAdd BLAST35
Coiled coili748 – 768Sequence analysisAdd BLAST21
Coiled coili783 – 824Sequence analysisAdd BLAST42
Coiled coili904 – 924Sequence analysisAdd BLAST21
Coiled coili936 – 992Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IESN Eukaryota
ENOG410XQHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PWI3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGCSVQP

Database of Orthologous Groups

More...
OrthoDBi
266426at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PWI3

TreeFam database of animal gene trees

More...
TreeFami
TF333056

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR040171 USBP1-like
IPR019536 USH1C-bd_PDZ_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23347 PTHR23347, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF10506 MCC-bdg_PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PWI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASACNSS GGSSDTSSTG EEERLRRLFQ TCDGDGDGYI SRNDLLMVCR
60 70 80 90 100
QLSMEESVAE IMNQLGSDEN GKISFQDFTR CHTQLVREIR KEEGDLSMKS
110 120 130 140 150
DMSSTKRLSE RITSWPTSSD NSLGALSAAR ESWEDDSGAR DLQSPDLQSQ
160 170 180 190 200
RPLQKLLEYG GSSLPQQAVL HKLLTHAPNF GTSTGGSYLE LASTLHLAAL
210 220 230 240 250
ASLKGDIVEL NKRLQQTERE RDLLEKKLAK AQCEQSHLMR EHEDVQERTT
260 270 280 290 300
LRYEERITEL HSIIAELNKK IDRLQGTTIR EEDEYSELRS ELSQSQQEVN
310 320 330 340 350
EDSRSVDQDQ TSVSIPENQS TMVTADMDNC SDLNSELQRV LTGLESVVCG
360 370 380 390 400
RKKSSCSLSV ADVDRHIEQL TTASEHCDLA IKTVEEIEGV LGRDLYPNLA
410 420 430 440 450
EERSRWEKEL AGLREENESL TAMLCSKEEE LNRTKATMNA IREERDRLRR
460 470 480 490 500
RVRELQTRLQ SVQATGPSSP GRLTPANRPI NPSTGELSTS SSSNDIPIAK
510 520 530 540 550
IAERVKLSKT RSESSSSDRP VLGSEISSIG VSSSVAEHLA HSLQDCSNIQ
560 570 580 590 600
EIFQTLYSHG SAISESKIRE FEVETERLNS RIEHLKSQND LLTITLEECK
610 620 630 640 650
SNAERMSMLV GKYESNATAL RLALQYSEQC IEAYELLLAL AESEQSLILG
660 670 680 690 700
QFRAAGVGSS PGDQSGDENI TQMLKRAHDC RKTAENAAKA LLMKLDGSCG
710 720 730 740 750
GAFAVAGCSV QPWESLSSNS HTSTTSSTAS SCDTEFTKED EQRLKDYIQQ
760 770 780 790 800
LKNDRAAVKL TMLELESIHI DPLSYDVKPR GDSQRLDLEN AVLMQELMAM
810 820 830 840 850
KEEMAELKAQ LYLLEKEKKA LELKLSTREA QEQAYLVHIE HLKSEVEEQK
860 870 880 890 900
EQRTRSLSST SSSGKEKPGK ECADAASPAL SLAELRTNSD SELATEFANA
910 920 930 940 950
IRREKKLKAR VQELVSALER LTKSSEIRHQ QSAEFVNDLK RANSNLVAAY
960 970 980 990 1000
EKAKKKHQNK LKKLESQMMA MVERHETQVR MLKQRIALLE EENSRPHTNE

TSL
Length:1,003
Mass (Da):111,993
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF488F60C961AF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UW40G3UW40_MOUSE
MCG4620, isoform CRA_b
Mcc mCG_4620
828Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC124191 Genomic DNA No translation available.
AC137150 Genomic DNA No translation available.
AC147551 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001078842.1, NM_001085373.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.312511
Mm.427116

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089874; ENSMUSP00000087318; ENSMUSG00000071856

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
328949

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:328949

UCSC genome browser

More...
UCSCi
uc008euz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124191 Genomic DNA No translation available.
AC137150 Genomic DNA No translation available.
AC147551 Genomic DNA No translation available.
RefSeqiNP_001078842.1, NM_001085373.1
UniGeneiMm.312511
Mm.427116

3D structure databases

ProteinModelPortaliE9PWI3
SMRiE9PWI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PWI3, 1 interactor
STRINGi10090.ENSMUSP00000087318

Proteomic databases

jPOSTiE9PWI3
MaxQBiE9PWI3
PaxDbiE9PWI3
PeptideAtlasiE9PWI3
PRIDEiE9PWI3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089874; ENSMUSP00000087318; ENSMUSG00000071856
GeneIDi328949
KEGGimmu:328949
UCSCiuc008euz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4163
MGIiMGI:96930 Mcc

Phylogenomic databases

eggNOGiENOG410IESN Eukaryota
ENOG410XQHM LUCA
GeneTreeiENSGT00530000063974
InParanoidiE9PWI3
OMAiTGCSVQP
OrthoDBi266426at2759
PhylomeDBiE9PWI3
TreeFamiTF333056

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000071856 Expressed in 240 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiE9PWI3 baseline and differential
GenevisibleiE9PWI3 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR040171 USBP1-like
IPR019536 USH1C-bd_PDZ_domain
PANTHERiPTHR23347 PTHR23347, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF10506 MCC-bdg_PDZ, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PWI3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PWI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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