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Protein
Submitted name:

Trafficking protein particle complex 8

Gene

Trappc8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Trafficking protein particle complex 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trappc8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443008 Trappc8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PWG2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PWG2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PWG2

PeptideAtlas

More...
PeptideAtlasi
E9PWG2

PRoteomics IDEntifications database

More...
PRIDEi
E9PWG2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PWG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PWG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033382 Expressed in 240 organ(s), highest expression level in blastocyst

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PWG2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PWG2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9PWG2, 20 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025177

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PWG2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1938 Eukaryota
ENOG410XPCJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000568

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PWG2

Database of Orthologous Groups

More...
OrthoDBi
625387at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106128

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR024420 TRAPP_III_complex_Trs85

The PANTHER Classification System

More...
PANTHERi
PTHR12975 PTHR12975, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PWG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFS ELLKPFSRLT
60 70 80 90 100
SEVHMRDPNN QLHIIKNLKI AVSNIVTQPP QPGAIGKLLN DVVSGSQPAE
110 120 130 140 150
GLVANVITAG DYDLNISATT PWFESYRETF LQSMPASDHE FLNHYLACML
160 170 180 190 200
VASSGEAEPM EQFSKLSQEQ HRIQHNNDYS YPKWFIPNTL KYYVLLHDVT
210 220 230 240 250
SGDEQRAESI YEEMKQKYGT QGCYLLKINS RAPNRASDEQ IPDPWSQYLQ
260 270 280 290 300
KNSIQNQESY EDGPCTMTSS KNSDSNLLSL DGLDNEVKVD GLPNNFRIHP
310 320 330 340 350
LQIDQCGDPP NNTDGSESKS ASSVHETKKA STAVIRGACL TLTDHDRIRQ
360 370 380 390 400
FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE
410 420 430 440 450
KSINELKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF
460 470 480 490 500
LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV
510 520 530 540 550
LAERCVLLSA EILKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI
560 570 580 590 600
NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE
610 620 630 640 650
DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY
660 670 680 690 700
KNVNQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHISLDQ
710 720 730 740 750
EYDSESSQQW RELEEHVVAV ANKGVIPSSF YPTQYCLNSY SDNSRFPLAV
760 770 780 790 800
VEEPITVEVA FRNPLKVPLL LSDLSLLWKF QPKDASGKDI EKVKERVTGE
810 820 830 840 850
PEMIGTEVIS EFLINSEESK VARLKLFPHH IGELHILGVV YNLGTIQGSG
860 870 880 890 900
TVDGIGALPG CHTGKHSLSM SVRGRQDLEI QGPRLNNTKE EKTSVKYGPD
910 920 930 940 950
RRLDPIVTEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV
960 970 980 990 1000
VSKRPEFFTF GGNTAALTPL SPSTSENCSA YKTVVTASPS LGTALVSTAS
1010 1020 1030 1040 1050
SMDFGTGTGQ QLEAIPVPLP DSVLLPGASI QLPMWLRGPD EEGVHEINFL
1060 1070 1080 1090 1100
FYYESVKKQP KKRHRILRHT AVICTSRSLN VRATVCRSNS LEDEEGRGGN
1110 1120 1130 1140 1150
MLVFVDVENT NTSEAGVKEF HMVQVSSSSK HWQLHKSVNI SENKDAKLAS
1160 1170 1180 1190 1200
REKGKFCFKA VRCKQKEGGI QSSEKYTFAD IIFGNEQIIS SASPCADFFY
1210 1220 1230 1240 1250
RSLSSELKKT QDQLSAYPEK HREATEGAVR LVEKCSEVDL SIVILWKAYV
1260 1270 1280 1290 1300
VEDNKQLILE GQHHVVVRTV GKEAFSHSQK EEPPEMELLK FFRPENTTVS
1310 1320 1330 1340 1350
TRPSVEQLSN LIKTSLHYPE SFHHPFHQKS LCLVPVTLLL SNCSKADVDV
1360 1370 1380 1390 1400
IVDLRHKTTS PEALETHGSF TWLGQTQYKL QLKSQEMHSL QLKACFVHTG
1410 1420 1430
VYNLGTPRVF AKLSDHVTVF ETSQQNSMPA LIIINNA
Length:1,437
Mass (Da):160,911
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9356E5AB047453E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PY51E9PY51_MOUSE
Trafficking protein particle comple...
Trappc8
822Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCX6A0A286YCX6_MOUSE
Trafficking protein particle comple...
Trappc8
1,436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCE0A0A286YCE0_MOUSE
Trafficking protein particle comple...
Trappc8
112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122118 Genomic DNA No translation available.
AC129078 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_796012.2, NM_177038.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.273769

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025177; ENSMUSP00000025177; ENSMUSG00000033382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
75964

UCSC genome browser

More...
UCSCi
uc012bad.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122118 Genomic DNA No translation available.
AC129078 Genomic DNA No translation available.
RefSeqiNP_796012.2, NM_177038.3
UniGeneiMm.273769

3D structure databases

SMRiE9PWG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PWG2, 20 interactors
STRINGi10090.ENSMUSP00000025177

PTM databases

iPTMnetiE9PWG2
PhosphoSitePlusiE9PWG2

Proteomic databases

jPOSTiE9PWG2
MaxQBiE9PWG2
PaxDbiE9PWG2
PeptideAtlasiE9PWG2
PRIDEiE9PWG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025177; ENSMUSP00000025177; ENSMUSG00000033382
GeneIDi75964
UCSCiuc012bad.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22878
MGIiMGI:2443008 Trappc8

Phylogenomic databases

eggNOGiKOG1938 Eukaryota
ENOG410XPCJ LUCA
GeneTreeiENSGT00390000000568
InParanoidiE9PWG2
OrthoDBi625387at2759
TreeFamiTF106128

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Trappc8 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033382 Expressed in 240 organ(s), highest expression level in blastocyst
ExpressionAtlasiE9PWG2 baseline and differential
GenevisibleiE9PWG2 MM

Family and domain databases

InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR024420 TRAPP_III_complex_Trs85
PANTHERiPTHR12975 PTHR12975, 1 hit
PfamiView protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PWG2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PWG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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