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Entry version 74 (31 Jul 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Ryanodine receptor 3

Gene

Ryr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99684 Ryr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4201 – 4225HelicalSequence analysisAdd BLAST25
Transmembranei4429 – 4449HelicalSequence analysisAdd BLAST21
Transmembranei4497 – 4516HelicalSequence analysisAdd BLAST20
Transmembranei4628 – 4646HelicalSequence analysisAdd BLAST19
Transmembranei4689 – 4710HelicalSequence analysisAdd BLAST22
Transmembranei4769 – 4792HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PW34

PRoteomics IDEntifications database

More...
PRIDEi
E9PW34

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PW34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057378 Expressed in 163 organ(s), highest expression level in caudate-putamen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PW34 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PW34 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PW34

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 175MIRInterPro annotationAdd BLAST56
Domaini182 – 227MIRInterPro annotationAdd BLAST46
Domaini235 – 289MIRInterPro annotationAdd BLAST55
Domaini295 – 353MIRInterPro annotationAdd BLAST59
Domaini363 – 420MIRInterPro annotationAdd BLAST58
Domaini605 – 816B30.2/SPRYInterPro annotationAdd BLAST212
Domaini1032 – 1228B30.2/SPRYInterPro annotationAdd BLAST197
Domaini1274 – 1486B30.2/SPRYInterPro annotationAdd BLAST213
Domaini3937 – 3972EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3601 – 3629DisorderedSequence analysisAdd BLAST29
Regioni4120 – 4151DisorderedSequence analysisAdd BLAST32
Regioni4351 – 4372DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili479 – 499Sequence analysisAdd BLAST21
Coiled coili3237 – 3257Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4126 – 4151AcidicSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155507

TreeFam database of animal gene trees

More...
TreeFami
TF315244

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50222 EF_HAND_2, 1 hit
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9PW34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVEATISIF HESIRHLDDH LLHYRPFNFY DPCFPMQEDE VVLQCIANIH
60 70 80 90 100
KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ
110 120 130 140 150
EMLANTVENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT
160 170 180 190 200
DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
210 220 230 240 250
YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH
260 270 280 290 300
DECLTIPSTD QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW
310 320 330 340 350
GQAFRLRHLT TGHYLALTED QGLLLQDRGK SDTKSTAFSF RASKEIKEKL
360 370 380 390 400
DSSHKRDMEG MGVPEIKYGD SVCFVQHVAS GLWVTYKAQD AKTSRLGPLK
410 420 430 440 450
RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ FVSGNNRTTA
460 470 480 490 500
PVALPTEEVL QTLQDLIAYF QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG
510 520 530 540 550
MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL YKLLAALIRG
560 570 580 590 600
NRNNCAQFSN NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH
610 620 630 640 650
IKSIISLLDK HGRNHKVLDV LCSLCLCNGV AVRANQNLIC DNLLPRRNLL
660 670 680 690 700
LQTRLINDVT SIRPNIFLGV AEGSPQYKKW YFELIIDQVE PFLTAEPTHL
710 720 730 740 750
RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS
760 770 780 790 800
INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
810 820 830 840 850
FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD
860 870 880 890 900
ADGVRDLLGT TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW
910 920 930 940 950
GMNKIELGWT YGKVRDDNKR QHPCLVEFSK LPETEKNYNL QMSTETLKTL
960 970 980 990 1000
LALGCHIAHV NPAAEEDLKK VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE
1010 1020 1030 1040 1050
ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV PYALLDERTK
1060 1070 1080 1090 1100
KSNRDSLREA VRTFVGYGYN IEPSDQELAD PTVEKVSIDK IRFFRVERSY
1110 1120 1130 1140 1150
AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR
1160 1170 1180 1190 1200
WHQGSGYFGR TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD
1210 1220 1230 1240 1250
YEIENGFVPI CSLGLSQIGR MNLGTDASTF KFYTMCGLQE GFEPFAVNMN
1260 1270 1280 1290 1300
RDVAVWFSKR LPTFVNVPKD HPHIEVVRID GTMDSPPCLK VTHKTFGTQN
1310 1320 1330 1340 1350
SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY
1360 1370 1380 1390 1400
AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
1410 1420 1430 1440 1450
SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG MLSFSANGKE
1460 1470 1480 1490 1500
LGTCYQVEPN TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK
1510 1520 1530 1540 1550
NPTPQCPPRL DVQTIQPVLW SRMPSSFLKV ETERVSERHG WVVQCLEPLQ
1560 1570 1580 1590 1600
MMALHIPEEN RCVDILELCE QEDLMQFHYH TLRLYSAVCA LGNSRVASAL
1610 1620 1630 1640 1650
CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE RKLMMKNEYI
1660 1670 1680 1690 1700
IPITSATRNI RLYPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ
1710 1720 1730 1740 1750
KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG
1760 1770 1780 1790 1800
TLLVMGVFDD DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA
1810 1820 1830 1840 1850
GEKACKEAPV KGLLQTRLPE SVKLQMCELL SYLCDCELQH RVEAIVAFGD
1860 1870 1880 1890 1900
IYVSKLQANQ KFRYNELMQA LNMSAALTAR KTREFRSPPQ EQINMLLNFH
1910 1920 1930 1940 1950
LGENCPCPEE IREELYDFHE DLLVHCGVPL EEEEEEEEDT SWTGKLCALV
1960 1970 1980 1990 2000
YKIKGPPKPE KEQPTEEEKP YPTTLKELVS QTMIRWAQEN QIQDAELVRM
2010 2020 2030 2040 2050
MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL GQIRSLLSVR
2060 2070 2080 2090 2100
MGREEELLMI NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK
2110 2120 2130 2140 2150
SQIAFPKMVA SCCRFLCYFC RISRQNQKAM FEHLSYLLEN SSVGLASPSM
2160 2170 2180 2190 2200
RGSTPLDVAA SSVMDNNELA LGLEEPDLEK VVTYLAGCGL QSCPMLLARG
2210 2220 2230 2240 2250
YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL IRRPECFGPA
2260 2270 2280 2290 2300
LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG
2310 2320 2330 2340 2350
NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI
2360 2370 2380 2390 2400
ISIPLKLPSL NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL
2410 2420 2430 2440 2450
HLLEVGFLPD LRASASLDTV SLSTTEAALA LNRYLCSAVL PLLTRCAPLF
2460 2470 2480 2490 2500
SGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ RDTIEECLLA ICNHLRPSML
2510 2520 2530 2540 2550
QQLLRRLVFD VPQLSEYCKM PLKLLTNHYE QCWKYYCLPS GWGSYGLAVE
2560 2570 2580 2590 2600
EELHLTEKLF WGIFDSLSHK KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI
2610 2620 2630 2640 2650
TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD
2660 2670 2680 2690 2700
KSHSGWKYGI SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV
2710 2720 2730 2740 2750
GWTVERTKEG EALVQQRENE KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL
2760 2770 2780 2790 2800
QGMVEVVAEN YHNIWAKKKK LELESKGGGS HPLLVPYDTL TAKEKFRDRE
2810 2820 2830 2840 2850
KAQDLFKFLQ VNGILVSRGM KDLELDASSM EKRFAYKFLK KILKYVDAAQ
2860 2870 2880 2890 2900
EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP
2910 2920 2930 2940 2950
LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL
2960 2970 2980 2990 3000
AQTLDTRTVM KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ
3010 3020 3030 3040 3050
IKGVSQNINY TTVALLPILT SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS
3060 3070 3080 3090 3100
LYSLGTGKNI YVERQRPALG ECLASLAAAI PVAFLEPSLN RHNPLSVFNT
3110 3120 3130 3140 3150
KTPRERSILG MPDKVEDMCP DIPQLEGLMK EINDLAESGA RYTEMPHVIE
3160 3170 3180 3190 3200
VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN
3210 3220 3230 3240 3250
NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE
3260 3270 3280 3290 3300
EEQLKTDGKG DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK
3310 3320 3330 3340 3350
SPDPDSDQLF RMVAEVFILW CKSHNFKREE QNFVIQNEIN NLAFLTGDSK
3360 3370 3380 3390 3400
SKMSKAMQVK SGGQDQERKK TKRRGDLYSI QTSLIVAALK KMLPIGLNMC
3410 3420 3430 3440 3450
TPGDQELISL AKSRYSCRDT DEEVKEHLRN NLHLQEKSDD PAVKWQLNLY
3460 3470 3480 3490 3500
KDVLRNDEPS NPEKTVERVQ SISAALFHLE QVEQPLRSKK AVWHKLLSKQ
3510 3520 3530 3540 3550
RKRAVVACFR MAPLYNLPRH RSINLFLHGY QRFWIETEAH FFEEKLVQDL
3560 3570 3580 3590 3600
AKSPRVEDEE EEETERQPDP LHQIILHFSR NALTERSKLE DDPLYTSYSS
3610 3620 3630 3640 3650
MMAKSCQSGE DEEEEEDKEK TFEEKEMEKQ KTLYQQARLH ERGAAEMVLQ
3660 3670 3680 3690 3700
MISASKGEMS PMVVETLKLG IAILNGGNAG VQQKMLDYLK EKKDAGFFQS
3710 3720 3730 3740 3750
LSGLMQSCSV LDLNAFERQN KAEGLGMVTE EGTLIVRERG EKVLQNDEFT
3760 3770 3780 3790 3800
QDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNIIISTVD YLLRLQESIS
3810 3820 3830 3840 3850
DFYWYYSGKD IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA
3860 3870 3880 3890 3900
HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL
3910 3920 3930 3940 3950
EGNVVNGTIG KQMVDTLVES STNVEMILKF FDMFLKLKDL TSSDTFKEYD
3960 3970 3980 3990 4000
PDGKGIISRK EFQKAMEGLK QYTQSEIDFL LSCTEADEND MFNYVDFVER
4010 4020 4030 4040 4050
FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK SLLDPAESVL NYFEPYLGRI
4060 4070 4080 4090 4100
EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM
4110 4120 4130 4140 4150
ELFVNFCEDT IFEMQLASQI SESDSTDRPE EEEEEDEDSA YSIETEGEEE
4160 4170 4180 4190 4200
EKSFESASAF TMACVSVKRN VTKFLKRATL KNLRKQYRNV KKMSAKELVK
4210 4220 4230 4240 4250
VFFSFFWMLF VGLFQLLFTI FGGIFQILWN TVFGGGLVEG AKNIRVTKIL
4260 4270 4280 4290 4300
GDMPDPTQFG IHDDVIETDR AEVTEPGVTT ELVHFVKGEA GDTDIMSDLF
4310 4320 4330 4340 4350
GIHSKKEGGL KQGPEVGLGD LSEIIGKDEP PTLESTVRKK RKAQAAEMKA
4360 4370 4380 4390 4400
VHEAEGKAES EKADMEDREK EDKIKEEGQT DYLWADVTVK KTRRRGQKAE
4410 4420 4430 4440 4450
KPEAFMANFF KGLEIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK
4460 4470 4480 4490 4500
VTEEPLEEET EDVANLWNSF NDDDEEEAMV FFVLQESTGY MAPTLRALAI
4510 4520 4530 4540 4550
VHTIISLVCV VGYYCLKVPL VVFKREKEIA RKLEFDGLYI TEQPSEDDIK
4560 4570 4580 4590 4600
GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKNAL
4610 4620 4630 4640 4650
DFSPVEEAKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS
4660 4670 4680 4690 4700
VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY
4710 4720 4730 4740 4750
LYTVVAFNFF RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
4760 4770 4780 4790 4800
EIEDPAGDPY EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
4810 4820 4830 4840 4850
VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD
4860 4870 4880
ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
Length:4,888
Mass (Da):554,567
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABDEE9857A6A3B37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AGL3RYR3_MOUSE
Ryanodine receptor 3
Ryr3
4,863Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJK7A0A140LJK7_MOUSE
Ryanodine receptor 3
Ryr3
4,868Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJF7A0A140LJF7_MOUSE
Ryanodine receptor 3
Ryr3
4,858Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI87A0A140LI87_MOUSE
Ryanodine receptor 3
Ryr3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL672250 Genomic DNA No translation available.
AL691423 Genomic DNA No translation available.
AL732316 Genomic DNA No translation available.
AL929348 Genomic DNA No translation available.
BX649564 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000091818; ENSMUSP00000089426; ENSMUSG00000057378

UCSC genome browser

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UCSCi
uc008lpg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672250 Genomic DNA No translation available.
AL691423 Genomic DNA No translation available.
AL732316 Genomic DNA No translation available.
AL929348 Genomic DNA No translation available.
BX649564 Genomic DNA No translation available.

3D structure databases

SMRiE9PW34
ModBaseiSearch...

PTM databases

SwissPalmiE9PW34

Proteomic databases

MaxQBiE9PW34
PRIDEiE9PW34

Genome annotation databases

EnsembliENSMUST00000091818; ENSMUSP00000089426; ENSMUSG00000057378
UCSCiuc008lpg.1 mouse

Organism-specific databases

MGIiMGI:99684 Ryr3

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000155507
TreeFamiTF315244

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ryr3 mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057378 Expressed in 163 organ(s), highest expression level in caudate-putamen
ExpressionAtlasiE9PW34 baseline and differential
GenevisibleiE9PW34 MM

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50222 EF_HAND_2, 1 hit
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PW34_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PW34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 31, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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