UniProtKB - E9PW15 (E9PW15_MOUSE)
Protein
Submitted name:
Polycomb protein Suz12
Gene
Suz12
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Polycomb protein Suz12Imported |
Gene namesi | Name:Suz12Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1261758, Suz12 |
PTM / Processingi
Proteomic databases
EPDi | E9PW15 |
jPOSTi | E9PW15 |
MaxQBi | E9PW15 |
PeptideAtlasi | E9PW15 |
PRIDEi | E9PW15 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017548, Expressed in secondary oocyte and 316 other tissues |
ExpressionAtlasi | E9PW15, baseline and differential |
Genevisiblei | E9PW15, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 526 – 658 | VEFS-BoxInterPro annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 666 – 718 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 677 – 696 | PolarSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.ARBA annotation
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000012364 |
HOGENOMi | CLU_014678_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR019135, Polycomb_protein_VEFS-Box |
Pfami | View protein in Pfam PF09733, VEFS-Box, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9PW15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA AVAAAASGGK SGGGGCGGGG
60 70 80 90 100
SYSASSSSAA AAAAAAGAAV LPVKKPKMEH VQADHELFLQ AFEKPTQIYR
110 120 130 140 150
FLRTRNLIAP IFLHRTLTYM SHRNSRTSIK SLSAHLQLTF TGFFHKNDKP
160 170 180 190 200
SQNSENEQNS VTLEVLLVKV CHKKRKDVSC PIRQVPTGKK QVPLNPDLNQ
210 220 230 240 250
TKPGNFPSLA VSSNEFEPSN SHMVKSYSLL FRVTRPGRRE FNGMINGETN
260 270 280 290 300
ENIDVSEELP ARRKRNREDG EKTFVAQMTV FDKNRRLQLL DGEYEVAMQE
310 320 330 340 350
MEECPISKKR ATWETILDGK RLPPFETFSQ GPTLQFTLRW TGETNDKSTA
360 370 380 390 400
PVAKPLATRN SESLHQENKP GSVKPAQTIA VKETLTTELQ TRKEKDNSNE
410 420 430 440 450
SRQKLRIFYQ FLYNNNTRQQ TEARDDLHCP WCTLNCRKLY SLLKHLKLCH
460 470 480 490 500
SRFIFNYVYH PKGARIDVSI NECYDGSYAG NPQDIHRQPG FAFSRNGPVK
510 520 530 540 550
RTPITHILVC RPKRTKASMS EFLESEDGEV EQQRTYSSGH NRLYFHSDTC
560 570 580 590 600
LPLRPQEMEV DSEDEKDPEW LREKTITQIE EFSDVNEGEK EVMKLWNLHV
610 620 630 640 650
MKHGFIADNQ MNHACMLFVE NYGQKIIKKN LCRNFMLHLV SMHDFNLISI
660 670 680 690 700
MSIDKAVTKL REMQQKLEKG ESATPSNEEI AEEQNGTANG FSETNSKEKA
710
LETDGVSGVP KQSKKQKL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ80U70 | SUZ12_MOUSE | Polycomb protein Suz12 | Suz12 D11Ertd530e, Kiaa0160 | 741 | Annotation score: | ||
F6Z494 | F6Z494_MOUSE | Polycomb protein Suz12 | Suz12 | 59 | Annotation score: | ||
F7B7H9 | F7B7H9_MOUSE | Polycomb protein Suz12 | Suz12 | 51 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591113 Genomic DNA No translation available. |
RefSeqi | NP_001156490.1, NM_001163018.1 |
Genome annotation databases
Ensembli | ENSMUST00000163272; ENSMUSP00000126932; ENSMUSG00000017548 |
GeneIDi | 52615 |
UCSCi | uc011yap.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL591113 Genomic DNA No translation available. |
RefSeqi | NP_001156490.1, NM_001163018.1 |
3D structure databases
SMRi | E9PW15 |
ModBasei | Search... |
Proteomic databases
EPDi | E9PW15 |
jPOSTi | E9PW15 |
MaxQBi | E9PW15 |
PeptideAtlasi | E9PW15 |
PRIDEi | E9PW15 |
Protocols and materials databases
Antibodypediai | 27067, 347 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000163272; ENSMUSP00000126932; ENSMUSG00000017548 |
GeneIDi | 52615 |
UCSCi | uc011yap.1, mouse |
Organism-specific databases
CTDi | 23512 |
MGIi | MGI:1261758, Suz12 |
Phylogenomic databases
GeneTreei | ENSGT00390000012364 |
HOGENOMi | CLU_014678_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 52615, 7 hits in 21 CRISPR screens |
ChiTaRSi | Suz12, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017548, Expressed in secondary oocyte and 316 other tissues |
ExpressionAtlasi | E9PW15, baseline and differential |
Genevisiblei | E9PW15, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019135, Polycomb_protein_VEFS-Box |
Pfami | View protein in Pfam PF09733, VEFS-Box, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PW15_MOUSE | |
Accessioni | E9PW15Primary (citable) accession number: E9PW15 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |