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Protein

Proliferation marker protein Ki-67

Gene

Mki67

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.By similarityCurated2 Publications

Caution

Was thought to play a key role in cell proliferation, and is commonly used as a marker of cell proliferation. However, its primary function is uncoupled from cell proliferation (PubMed:26949251). Required to maintain mitotic chromosomes dispersed by forming a steric and electrostatic charge barrier (PubMed:27362226).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2973 – 2980ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proliferation marker protein Ki-67Curated
Alternative name(s):
Antigen identified by monoclonal antibody Ki-67 homologCurated
Short name:
Antigen KI-67 homologCurated
Short name:
Antigen Ki67 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mki67Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106035 Mki67

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Mice were born at the expected Mendelian ratio and show no overt phenotype (PubMed:26949251). Cells do not show proliferation defects, but chromatin organization is impaired, with defects in heterochromatin compaction and long-range genomic interactions (PubMed:26949251).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004375351 – 3177Proliferation marker protein Ki-67Add BLAST3177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei162PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei250PhosphoserineBy similarity1
Modified residuei276PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei307PhosphothreonineBy similarity1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei337PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei503PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei701PhosphothreonineBy similarity1
Cross-linki1013Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1026Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1062PhosphoserineBy similarity1
Cross-linki1082Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1082Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1114PhosphoserineBy similarity1
Modified residuei1122PhosphothreonineBy similarity1
Modified residuei1125PhosphoserineBy similarity1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1159PhosphothreonineCombined sources1
Modified residuei1175PhosphothreonineCombined sources1
Modified residuei1189PhosphoserineBy similarity1
Modified residuei1215PhosphothreonineBy similarity1
Modified residuei1235PhosphoserineBy similarity1
Modified residuei1243PhosphothreonineBy similarity1
Modified residuei1279PhosphothreonineBy similarity1
Modified residuei1295PhosphothreonineBy similarity1
Modified residuei1307PhosphothreonineBy similarity1
Modified residuei1315PhosphothreonineBy similarity1
Cross-linki1317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1335PhosphothreonineBy similarity1
Modified residuei1356PhosphoserineBy similarity1
Modified residuei1363PhosphothreonineCombined sources1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1400PhosphothreonineCombined sources1
Modified residuei1416PhosphothreonineCombined sources1
Modified residuei1469PhosphoserineCombined sources1
Modified residuei1477PhosphothreonineBy similarity1
Modified residuei1480PhosphoserineBy similarity1
Modified residuei1513PhosphothreonineBy similarity1
Modified residuei1542PhosphoserineBy similarity1
Modified residuei1587PhosphoserineCombined sources1
Modified residuei1609N6-acetyllysineBy similarity1
Cross-linki1668Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1684PhosphothreonineBy similarity1
Modified residuei1712PhosphothreonineBy similarity1
Modified residuei1734PhosphoserineCombined sources1
Modified residuei1766PhosphothreonineBy similarity1
Modified residuei1779PhosphoserineBy similarity1
Modified residuei1805PhosphothreonineBy similarity1
Modified residuei1825PhosphoserineCombined sources1
Modified residuei1859PhosphothreonineBy similarity1
Modified residuei1868PhosphothreonineCombined sources1
Modified residuei1884PhosphothreonineCombined sources1
Modified residuei1924PhosphothreonineBy similarity1
Modified residuei1944PhosphoserineBy similarity1
Modified residuei1966N6-acetyllysineBy similarity1
Modified residuei1989PhosphothreonineCombined sources1
Modified residuei2005PhosphothreonineCombined sources1
Modified residuei2025PhosphothreonineBy similarity1
Cross-linki2027Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki2027Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei2045PhosphothreonineBy similarity1
Modified residuei2065PhosphoserineBy similarity1
Modified residuei2073PhosphothreonineCombined sources1
Modified residuei2076PhosphoserineCombined sources1
Modified residuei2095PhosphoserineBy similarity1
Modified residuei2103PhosphoserineCombined sources1
Modified residuei2106PhosphothreonineCombined sources1
Modified residuei2122PhosphothreonineCombined sources1
Modified residuei2162PhosphothreonineBy similarity1
Modified residuei2182PhosphoserineBy similarity1
Modified residuei2190PhosphothreonineBy similarity1
Modified residuei2198PhosphoserineBy similarity1
Modified residuei2218PhosphothreonineCombined sources1
Modified residuei2220PhosphoserineCombined sources1
Modified residuei2227PhosphothreonineCombined sources1
Modified residuei2243PhosphothreonineCombined sources1
Modified residuei2283PhosphothreonineBy similarity1
Modified residuei2303PhosphoserineBy similarity1
Modified residuei2311PhosphothreonineBy similarity1
Modified residuei2348PhosphothreonineBy similarity1
Modified residuei2390PhosphoserineCombined sources1
Modified residuei2392PhosphoserineCombined sources1
Modified residuei2405PhosphothreonineBy similarity1
Modified residuei2423PhosphoserineCombined sources1
Modified residuei2425PhosphoserineCombined sources1
Cross-linki2451Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei2464PhosphoserineBy similarity1
Modified residuei2487PhosphoserineBy similarity1
Modified residuei2545PhosphoserineCombined sources1
Modified residuei2592PhosphoserineBy similarity1
Modified residuei2649PhosphoserineBy similarity1
Cross-linki2675Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki2675Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei2768PhosphoserineBy similarity1
Modified residuei2780PhosphoserineCombined sources1
Cross-linki2909Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2928N6-acetyllysineCombined sources1
Modified residuei2980PhosphoserineBy similarity1
Modified residuei3021PhosphothreonineCombined sources1
Modified residuei3061PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Hyperphosphorylated in mitosis. Hyperphosphorylated form does not bind DNA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PVX6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
E9PVX6

PeptideAtlas

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PeptideAtlasi
E9PVX6

PRoteomics IDEntifications database

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PRIDEi
E9PVX6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
E9PVX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PVX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly present in proliferating cells (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Accumulates during the late G1 stage in the nucleus and maximum expression is found during G2 phase and mitosis (PubMed:8834799). During male meiosis, present in nuclei of all stages from the spermatogonium through spermatocytes I and II up to the earliest spermatid stage (early round spermatids) and then fades out (PubMed:12355204). Not detected in later spermatid stages or sperm (PubMed:12355204). During female meiosis, present in prophase I oocytes of fetal ovaries, while it is absent in resting oocytes. Reappears in oocytes of growing follicles and is continuously present up to metaphase II (at protein level) (PubMed:12355204).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000031004 Expressed in 270 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
E9PVX6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
E9PVX6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIF15. Interacts (via the FHA domain) with NIFK. Interacts with PPP1CC. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E9PVX6, 19 interactors

Molecular INTeraction database

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MINTi
E9PVX6

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000033310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
E9PVX6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
E9PVX6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 76FHAPROSITE-ProRule annotationAdd BLAST50
Domaini462 – 509PP1-bindingSequence analysisAdd BLAST48
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati994 – 1101K167R 1Sequence analysisAdd BLAST108
Repeati1108 – 1216K167R 2Sequence analysisAdd BLAST109
Repeati1228 – 1336K167R 3Sequence analysisAdd BLAST109
Repeati1348 – 1450K167R 4Sequence analysisAdd BLAST103
Repeati1461 – 1569K167R 5Sequence analysisAdd BLAST109
Repeati1582 – 1684K167R 6Sequence analysisAdd BLAST103
Repeati1696 – 1806K167R 7Sequence analysisAdd BLAST111
Repeati1817 – 1925K167R 8Sequence analysisAdd BLAST109
Repeati1937 – 2046K167R 9Sequence analysisAdd BLAST110
Repeati2059 – 2163K167R 10Sequence analysisAdd BLAST105
Repeati2175 – 2284K167R 11Sequence analysisAdd BLAST110
Repeati2296 – 2405K167R 12Sequence analysisAdd BLAST110
Repeati2419 – 2526K167R 13Sequence analysisAdd BLAST108
Repeati2643 – 2748K167R 15Sequence analysisAdd BLAST106
Repeati2762 – 2870K167R 16Sequence analysisAdd BLAST109

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410JR7C Eukaryota
ENOG410ZXYW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113223

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006213

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9PVX6

KEGG Orthology (KO)

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KOi
K17582

Identification of Orthologs from Complete Genome Data

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OMAi
FQTPEHT

Database of Orthologous Groups

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OrthoDBi
EOG091G005S

TreeFam database of animal gene trees

More...
TreeFami
TF336000

Family and domain databases

Conserved Domains Database

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CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR012568 KI67R
IPR029334 PP1-bd
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF08065 KI67R, 16 hits
PF15276 PP1_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00240 FHA, 1 hit
SM01295 K167R, 16 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: E9PVX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSAHLVTI KRSGDDGAHF PLSLSSCLFG RSIECDIRIQ LPVVSKRHCK
60 70 80 90 100
IEVKEQEAIL YNFSSTNPTQ VNGVTIDEPV RLRHGDIITI IDRSFRYEDG
110 120 130 140 150
NHEDGSKPTE FPGKSLGKEP SRRASRDSFC ADPDGEGQDT KASKMTASRR
160 170 180 190 200
SFVYAKGLSA DSPASDGSKN SVSQDSSGHV EQHTGRNIVE PTSGDLFKKS
210 220 230 240 250
RSTGSSYREP KSSPTQSLSN SNEKESPFEK LYQSMKEELD VKSQKSCRKS
260 270 280 290 300
EPQPDRAAEE SRETQLLVSG RARAKSSGST PVTAASSPKV GKIWTERWRG
310 320 330 340 350
GMVPVQTSTE TAKMKTPVRH SQQLKDEDSR VTGRRHSVNL DEGESAQAVH
360 370 380 390 400
KTVTPGKLAT RNQAAVEAGD VASPADTPEH SSSKKRSIPA KVEAPSAETQ
410 420 430 440 450
KRLSLTQRLV PGEKKTPKGS FSKPEKLATA AEQTCSGLPG LSSVDISNFG
460 470 480 490 500
DSINKSEGMP MKRRRVSFGG HLRPELFDEN LPPNTPLKRG ETPTKRKSLG
510 520 530 540 550
THSPAVLKTI IKERPQSPGK QESPGITPPR TNDQRRRSGR TSSGSKFLCE
560 570 580 590 600
TDIPKKAGRK SGNLPAKRAS ISRSQHGILQ MICSKRRSGA SEANLIVAKS
610 620 630 640 650
WADVVKLGVK QTQTKVAKHV PQKQTSKRQR RPSTPKKPTS NLHNQFTTGH
660 670 680 690 700
ANSPCTIVVG RAQIEKVSVP ARPYKMLNNL MLNRKVDFSE DLSGLTEMFK
710 720 730 740 750
TPVKEKQQQM SDTGSVLSNS ANLSERQLQV TNSGDIPEPI TTEILGEKVL
760 770 780 790 800
SSTRNAAKQQ SDRYSASPTL RRRSIKHENT VQTPKNVHNI TDLEKKTPVS
810 820 830 840 850
ETEPLKTASS VSKLRRSREL RHTLVETMNE KTEAVLAENT TARHLRGTFR
860 870 880 890 900
EQKVDQQVQD NENAPQRCKE SGELSEGSEK TSARRSSARK QKPTKDLLGS
910 920 930 940 950
QMVTQTADYA EELLSQGQGT IQNLEESMHM QNTSISEDQG ITEKKVNIIV
960 970 980 990 1000
YATKEKHSPK TPGKKAQPLE GPAGLKEHFE TPNPKDKPIT EDRTRVLCKS
1010 1020 1030 1040 1050
PQVTTENITT NTKPQTSTSG KKVDMKEESS ALTKRIHMPG ESRHNPKILK
1060 1070 1080 1090 1100
LECEDIKALK QSENEMLTST VNGSKRTLEK SKKKAQPLED LTCFQELFIS
1110 1120 1130 1140 1150
PVPTNIIKKI PSKSPHTQPV RTPASTKRLS KTGLSKVDVR QEPSTLGKRT
1160 1170 1180 1190 1200
KSPGRAPGTP APVQEENDST AFMETPKQKL DFAGNSSGSK RRSRTSKNRS
1210 1220 1230 1240 1250
QPLEDLDGFQ ELFQTPAGAS DSVTVEESAK ISLESSQAEP VKTPASTKRR
1260 1270 1280 1290 1300
SKMSLMKVDM KELSILEKQT QSRGRDAGTP APMQEGNGTT AIMETPKQKL
1310 1320 1330 1340 1350
DFTGNSTGHK RRPRTPKIRA QPLEDLDGFQ ELFQTPAGAN DSVTVEESAK
1360 1370 1380 1390 1400
MSLESSQAEP VKTPASTKRL SKTDLSKVDV REDPSILGKK TKSPGRAPGT
1410 1420 1430 1440 1450
PAPVQEENDC TAYMETPKQK LESIENLTGL RKQSRTPKDI TGFQDSFQIP
1460 1470 1480 1490 1500
DHANGPLVVV KTKKMFFNSP QPESAITRKS RERQSRASIS KIDVKEELLE
1510 1520 1530 1540 1550
SEEHLQLGEG VDTFQVSTNK VIRSSRKPAK RKLDSTAGMP NSKRMRCSSK
1560 1570 1580 1590 1600
DNTPCLEDLN GFQELFQMPG YANDSLTTGI STMLARSPQL GPVRTQINKK
1610 1620 1630 1640 1650
SLPKIILRKM DVTEEISGLW KQSLGRVHTT QEQEDNAIKA IMEIPKETLQ
1660 1670 1680 1690 1700
TAADGTRLTR QPQTPKEKVQ PLEDHSVFQE LFQTSRYCSD PLIGNKQTRM
1710 1720 1730 1740 1750
SLRSPQPGFV RTPRTSKRLA KTSVGNIAVR EKISPVSLPQ CATGEVVHIP
1760 1770 1780 1790 1800
IGPEDDTENK GVKESTPQTL DSSASRTVSK RQQGAHEERP QFSGDLFHPQ
1810 1820 1830 1840 1850
ELFQTPASGK DPVTVDETTK IALQSPQPGH IINPASMKRQ SNMSLRKDMR
1860 1870 1880 1890 1900
EFSILEKQTQ SRGRDAGTPA PMQEENGTTA IMETPKQKLD FIGNSTGHKR
1910 1920 1930 1940 1950
RPRTPKNRAQ PLEDLDGFQE LFQTPAGASD PVSVEESAKI SLASSQAEPV
1960 1970 1980 1990 2000
RTPASTKRRS KTGLSKVDVR QEPSTLGKRM KSLGRAPGTP APVQEENDST
2010 2020 2030 2040 2050
AFMETPKQKL DFTGNSSGHK RRPQTPKIRA QPLEDLDGFQ ELFQTPAGAN
2060 2070 2080 2090 2100
DSVTVEESVK MSLESSQAEP VKTPASTKRL SKTGLSKVDV REDPSILEKK
2110 2120 2130 2140 2150
TKSPGTPAPV QEENDCTAFM ETPKQKLDFT GNSSGHKRRP RTPKIRAQPL
2160 2170 2180 2190 2200
EDLDGFQELF QTPAGASDSV TVEESAKMSL ESSQAKPVKT PASTKRLSKT
2210 2220 2230 2240 2250
GLSKVDVRED PSTLGKKTKS PGRAPGTPAP VQEENDSTAF METPKQKLDF
2260 2270 2280 2290 2300
AENSSGSKRR SRTSKNRSQP LEDLDGFQEL FQTPAGASNP VSVEESAKIS
2310 2320 2330 2340 2350
LESSQAEPVR TRASTKRLSK TGLNKMDVRE GHSPLSKSSC ASQKVMQTLT
2360 2370 2380 2390 2400
LGEDHGRETK DGKVLLAQKL EPAIYVTRGK RQQRSCKKRS QSPEDLSGVQ
2410 2420 2430 2440 2450
EVFQTSGHNK DSVTVDNLAK LPSSSPPLEP TDTSVTSRRQ ARTGLRKVHV
2460 2470 2480 2490 2500
KNELSGGIMH PQISGEIVDL PREPEGEGKV IKTRKQSVKR KLDTEVNVPR
2510 2520 2530 2540 2550
SKRQRITRAE KTLEDLPGFQ ELCQAPSLVM DSVIVEKTPK MPDKSPEPVD
2560 2570 2580 2590 2600
TTSETQARRR LRRLVVTEEP IPQRKTTRVV RQTRNTQKEP ISDNQGMEEF
2610 2620 2630 2640 2650
KESSVQKQDP SVSLTGRRNQ PRTVKEKTQP LEELTSFQEE TAKRISSKSP
2660 2670 2680 2690 2700
QPEEKETLAG LKRQLRIQLI NDGVKEEPTA QRKQPSRETR NTLKEPVGDS
2710 2720 2730 2740 2750
INVEEVKKST KQKIDPVASV PVSKRPRRVP KEKAQALELA GLKGPIQTLG
2760 2770 2780 2790 2800
HTDESASDKG PTQMPCNSLQ PEQVDSFQSS PRRPRTRRGK VEADEEPSAV
2810 2820 2830 2840 2850
RKTVSTSRQT MRSRKVPEIG NNGTQVSKAS IKQTLDTVAK VTGSRRQLRT
2860 2870 2880 2890 2900
HKDGVQPLEV LGDSKEITQI SDHSEKLAHD TSILKSTQQQ KPDSVKPLRT
2910 2920 2930 2940 2950
CRRVLRASKE DPKEVLVDTR DHATLQSKSN PLLSPKRKSA RDGSIVRTRA
2960 2970 2980 2990 3000
LRSLAPKQEA TDEKPVPEKK RAASSKRHVS PEPVKMKHLK IVSNKLESVE
3010 3020 3030 3040 3050
EQVSTVMKTE EMEAKRENPV TPDQNSRYRK KTNVKQPRPK FDASAENVGI
3060 3070 3080 3090 3100
KKNEKTMKTA SQETELQNPD DGAKKSTSRG QVSGKRTCLR SRGTTEMPQP
3110 3120 3130 3140 3150
CEAEEKTSKP AAEILIKPQE EKGVSGESDV RCLRSRKTRV ALDSEPKPRV
3160 3170
TRGTKKDAKT LKEDEDIVCT KKLRTRS
Length:3,177
Mass (Da):350,864
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i969A3BE300D755B0
GO
Isoform 2 (identifier: E9PVX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1390: Missing.

Show »
Length:2,936
Mass (Da):324,718
Checksum:iC7E2B31758362698
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GQV9A0A1B0GQV9_MOUSE
Proliferation marker protein Ki-67
Mki67
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH53453 differs from that shown. Reason: Frameshift at position 2463.Curated
The sequence CAA58026 differs from that shown. Reason: Frameshift at positions 46, 54, 194, 213, 2853 and 2860.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344E → G in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti364 – 365AA → TP in CAA58026 (PubMed:8834799).Curated2
Sequence conflicti372A → G in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti384 – 385KK → PQ in CAA58026 (PubMed:8834799).Curated2
Sequence conflicti401K → N in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti546K → N in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti622Q → P in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti1079E → G in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti2911D → V in CAA58026 (PubMed:8834799).Curated1
Sequence conflicti2978H → Y in CAA58026 (PubMed:8834799).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0585511150 – 1390Missing in isoform 2. Add BLAST241

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82786 mRNA Translation: CAA58026.1 Frameshift.
AC123047 Genomic DNA No translation available.
BC053453 mRNA Translation: AAH53453.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52421.1 [E9PVX6-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T30249

NCBI Reference Sequences

More...
RefSeqi
NP_001074586.2, NM_001081117.2 [E9PVX6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.4078

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033310; ENSMUSP00000033310; ENSMUSG00000031004 [E9PVX6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17345

UCSC genome browser

More...
UCSCi
uc009kem.2 mouse [E9PVX6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The contours of heredity - Issue 186 of December 2016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82786 mRNA Translation: CAA58026.1 Frameshift.
AC123047 Genomic DNA No translation available.
BC053453 mRNA Translation: AAH53453.1 Frameshift.
CCDSiCCDS52421.1 [E9PVX6-1]
PIRiT30249
RefSeqiNP_001074586.2, NM_001081117.2 [E9PVX6-1]
UniGeneiMm.4078

3D structure databases

ProteinModelPortaliE9PVX6
SMRiE9PVX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PVX6, 19 interactors
MINTiE9PVX6
STRINGi10090.ENSMUSP00000033310

PTM databases

iPTMnetiE9PVX6
PhosphoSitePlusiE9PVX6

Proteomic databases

MaxQBiE9PVX6
PaxDbiE9PVX6
PeptideAtlasiE9PVX6
PRIDEiE9PVX6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033310; ENSMUSP00000033310; ENSMUSG00000031004 [E9PVX6-1]
GeneIDi17345
KEGGimmu:17345
UCSCiuc009kem.2 mouse [E9PVX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4288
MGIiMGI:106035 Mki67

Phylogenomic databases

eggNOGiENOG410JR7C Eukaryota
ENOG410ZXYW LUCA
GeneTreeiENSGT00940000154352
HOGENOMiHOG000113223
HOVERGENiHBG006213
InParanoidiE9PVX6
KOiK17582
OMAiFQTPEHT
OrthoDBiEOG091G005S
TreeFamiTF336000

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mki67 mouse

Protein Ontology

More...
PROi
PR:E9PVX6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031004 Expressed in 270 organ(s), highest expression level in liver
ExpressionAtlasiE9PVX6 baseline and differential
GenevisibleiE9PVX6 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR012568 KI67R
IPR029334 PP1-bd
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF08065 KI67R, 16 hits
PF15276 PP1_bind, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM01295 K167R, 16 hits
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI67_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PVX6
Secondary accession number(s): Q61769, Q7TSF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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