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Protein
Submitted name:

Unconventional myosin-VI

Gene

Myo6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 158ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-399719 Trafficking of AMPA receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-VIImported
Gene namesi
Name:Myo6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:104785 Myo6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PVU0
PeptideAtlasiE9PVU0
PRIDEiE9PVU0

PTM databases

iPTMnetiE9PVU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000033577 Expressed in 272 organ(s), highest expression level in saccule of membranous labyrinth
ExpressionAtlasiE9PVU0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PVU0
SMRiE9PVU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 53Myosin N-terminal SH3-likeInterPro annotationAdd BLAST52
Domaini57 – 771Myosin motorInterPro annotationAdd BLAST715

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 673Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili864 – 898Sequence analysisAdd BLAST35
Coiled coili902 – 984Sequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9PVU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNVKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSD TIKSYQGKSL GTMPPHVFAI ADKAFRDMKV LKMSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR EKLHLSSPDN FRYLNRGCTR FFANKETDKQ ILQNRKSPEY
310 320 330 340 350
VKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSAP SLEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GTKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEV KLVGILDILD EENRLPQPSD QHFTSVVHQK
560 570 580 590 600
HKDHFRLTIP RKSKLAVHRN LRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIRAL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGFPSRAS FHELYNMYKK YMPEKLARLD PRLFCKALFK ALGLNEVDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNLWLVC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSAL KDGKPEVNRQ IKNLEISIDA LMAKIKSTMM TREQIQKEYD
910 920 930 940 950
ALVKSSEDLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEERRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ
1010 1020 1030 1040 1050
AVLAQECRDR ELALRIAQNE SELISDEAQG DMALRREQMA KEMSEILSRG
1060 1070 1080 1090 1100
PAVQATKAAA GTKKHDLSKW KYAELRDTIN TSCDIELLAA CREEFHRRLK
1110 1120 1130 1140 1150
VYHAWKSKNK KRNTETEQRA PKSVTDYAQQ NPAAQLPARQ QEIDMKRQQR
1160 1170 1180 1190 1200
FFRIPFIRPA DQYKDPQNKK KGWWYAHFDG PWIARQMELH PDKPPILLVA
1210 1220 1230 1240 1250
GKDDMEMCEL NLEETGLTRK RGAEILPRQF EEIWERCGGI QYLQSAIESR
1260
QARPTYATAM LQNLLK
Length:1,266
Mass (Da):146,307
Last modified:April 5, 2011 - v1
Checksum:i7767BA42D9741ED0
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q64331MYO6_MOUSE
Unconventional myosin-VI
Myo6 Sv
1,265Annotation score:
E9Q3L1E9Q3L1_MOUSE
Unconventional myosin-VI
Myo6
1,262Annotation score:
E9Q175E9Q175_MOUSE
Unconventional myosin-VI
Myo6
1,253Annotation score:
V9GX76V9GX76_MOUSE
Unconventional myosin-VI
Myo6
1,294Annotation score:
E9Q174E9Q174_MOUSE
Unconventional myosin-VI
Myo6
1,284Annotation score:
V9GXM4V9GXM4_MOUSE
Unconventional myosin-VI
Myo6
1,285Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120388 Genomic DNA No translation available.
AC159738 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000076140; ENSMUSP00000075501; ENSMUSG00000033577

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120388 Genomic DNA No translation available.
AC159738 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PVU0
SMRiE9PVU0
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiE9PVU0

Proteomic databases

MaxQBiE9PVU0
PeptideAtlasiE9PVU0
PRIDEiE9PVU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076140; ENSMUSP00000075501; ENSMUSG00000033577

Organism-specific databases

MGIiMGI:104785 Myo6

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-399719 Trafficking of AMPA receptors

Miscellaneous databases

ChiTaRSiMyo6 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033577 Expressed in 272 organ(s), highest expression level in saccule of membranous labyrinth
ExpressionAtlasiE9PVU0 baseline and differential

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PVU0_MOUSE
AccessioniPrimary (citable) accession number: E9PVU0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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