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Protein
Submitted name:

Crystallin beta-gamma domain-containing 1

Gene

Crybg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Crystallin beta-gamma domain-containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crybg1Imported
Synonyms:Aim1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109544 Crybg1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PVP1

PeptideAtlas

More...
PeptideAtlasi
E9PVP1

PRoteomics IDEntifications database

More...
PRIDEi
E9PVP1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PVP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PVP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019866 Expressed in 158 organ(s), highest expression level in substantia propria of cornea

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PVP1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PVP1 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PVP1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PVP1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini994 – 1033Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST40
Domaini1034 – 1087Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST54
Domaini1134 – 1176Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini1188 – 1240Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST53
Domaini1241 – 1283Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini1289 – 1331Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini1332 – 1374Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST43
Domaini1385 – 1422Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST38
Domaini1423 – 1466Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST44
Domaini1472 – 1512Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST41
Domaini1513 – 1554Beta/gamma crystallin 'Greek key'InterPro annotationAdd BLAST42
Domaini1556 – 1689Ricin B-type lectinInterPro annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.SAAS annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IERF Eukaryota
ENOG4110BHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155695

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PVP1

Database of Orthologous Groups

More...
OrthoDBi
89929at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00161 RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00030 Crystall, 6 hits
PF00652 Ricin_B_lectin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01367 BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 11 hits
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PVP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKRSSGRRS GRRRKSQKST DSPGADAVAP ESAAKDEAVF DDEVAPDAAA
60 70 80 90 100
ENCLAERKVK SVQAVPDGGA APVACPEPKA SSCPRGQPRG EPDRSKPLSP
110 120 130 140 150
TKRKGRSRVP EAVPSSPGSG SRAPAKESPP KRAPAAADSG EEAGRVVPRE
160 170 180 190 200
LTVKSSSLLP EIKPEHKRGP LPHHFDSRGD GGRSRGTGAS DADGLKPRNQ
210 220 230 240 250
FGVGRSTVTT KVTLPARPKH VELNLKTPKN PDSLGNEHNS FSQPVHKGNT
260 270 280 290 300
ANKISLFENK RANSSPRHPD VRNTRNNPPS SKTFVGRAKL NLAKKAKEME
310 320 330 340 350
QPEKKAVSTS HQNGLVVKEP SAEGKGTAVP VPREEIRPAT RGGEGESTKD
360 370 380 390 400
QVLRPEPEQS DKLDVQTDTA YPSHPGPTAL VPVKDSELSG EGQPEAADSK
410 420 430 440 450
GPVLNNTSDV AQDIAAICDA REAPPKPQDA FSDSQPASAA ESARESSLPP
460 470 480 490 500
SAPISVDAPQ DGCVQVPICS VPCTALEVSE NHNGCVSPVS PHTEKTPISK
510 520 530 540 550
PGVGEASPPS TPEHSPETMG KDCPSKVLVQ VRSFVLPVEN PQDVSSQVIS
560 570 580 590 600
ESSEVREAQL PSCHSNEPEV VSVTTCVPQH EDAPDTSPKD IHHREGHVAQ
610 620 630 640 650
SRPHITQSGP EKAPPIQSSS GMPQTAEFIL THSPSSRSHA EGPQRPGQDA
660 670 680 690 700
TSPLTPTRLL NISAGSDNSV LDSSSDMEKF TEIIKKMDSA VCVPQKKKKA
710 720 730 740 750
RVPNSPAPHF AMPPIHEDSL EKVFDPNVFT IGLGKKKESL AEVSPALHLL
760 770 780 790 800
QNHDPISKLR AKRASTEQSI VFKSLHTNSN GKSEPQTTSE ASDKENRDIN
810 820 830 840 850
SGGVKRSRLE NSTLFSSMLS SLPQDKVFSP SVTSVNTMST SFSTSQNSSV
860 870 880 890 900
SQSSVVQPRK EGGLPCGSDK EQPHLAPHNS LKVFNFNSSN TSRLGSSHME
910 920 930 940 950
KYPQKEGSKE DVNSQGNLQL PENNLSDLPK LKNSDGVEGI LKSNLPNVGS
960 970 980 990 1000
VDADFLGLFK ASRYDPGHSF SGMSLSDSMT LRGSMHSKLN PRPGKVVIFS
1010 1020 1030 1040 1050
EPDVSEECIE VFGDIQDCSS WRLSPVIVVK VVRGCWILYE KANFEGHSLA
1060 1070 1080 1090 1100
LEEGELELSS IWGTEEMLDE EAESDKPVVI GSIRHVVQDY RISQIDLFTE
1110 1120 1130 1140 1150
PEGLGLLNSY FDDTEEMQGF PVMQKTCSIK VHWGTWLIYE EPGFQGVPFI
1160 1170 1180 1190 1200
LEPGEYPDLS FWDTEEAYIG SMRPLKMGGR KVEFPTDPKV VIYEKPSFEG
1210 1220 1230 1240 1250
RCMELETEMS SFIMEGGETE ETTGNNNLPF TSVGSMKVLR GVWVAYEKCG
1260 1270 1280 1290 1300
FTGHQYLLEE GEYRDWNAWG GYNGELQSLR PILSDFSNAH MIMYSEKNFG
1310 1320 1330 1340 1350
SKGSSIDVLG IVANLKETGY GVKTQSINVL SGVWVAYENP DFTGEQYVLD
1360 1370 1380 1390 1400
KGFYTSFEDW GGKNCKISSV QPICLDSFTG PRRRNQIHLF SEPQFQGQSQ
1410 1420 1430 1440 1450
SFEETIDQID DSFQTKSCRV LGGSWVAYDG ENFSGNQYVL EEGHYPCLSA
1460 1470 1480 1490 1500
MGCLPGATLK SLRFIDFEFS EPTIILFERE NFKGKKIELN AETVNLRSLG
1510 1520 1530 1540 1550
FNTQIRSVRV VGGIWVTYEY GNYRGRQFLL SPAEVPNWYE FSACRQIGSL
1560 1570 1580 1590 1600
RPFAQKRIYF RLRNKATGLF MSTNGNLEDL KLLRVQVMED VGADDQIWIY
1610 1620 1630 1640 1650
QEGCIKCRIA EDCCLTIVGS LVTSGSKLGL ALDQNVDSQF WCMKSDGRIY
1660 1670 1680 1690
SKMKPNLVLD VKGGAQYDQN HIILNTVSTE KLTQVWEAMV L
Length:1,691
Mass (Da):184,731
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB37CF96158D166F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JG52A0A0G2JG52_MOUSE
Crystallin beta-gamma domain-contai...
Crybg1 Aim1
2,065Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC153534 Genomic DNA No translation available.
AC153863 Genomic DNA No translation available.
AC158637 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_765981.2, NM_172393.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.292082

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020017; ENSMUSP00000020017; ENSMUSG00000019866

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11630

UCSC genome browser

More...
UCSCi
uc007ezq.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153534 Genomic DNA No translation available.
AC153863 Genomic DNA No translation available.
AC158637 Genomic DNA No translation available.
RefSeqiNP_765981.2, NM_172393.2
UniGeneiMm.292082

3D structure databases

ProteinModelPortaliE9PVP1
SMRiE9PVP1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiE9PVP1
PhosphoSitePlusiE9PVP1

Proteomic databases

MaxQBiE9PVP1
PeptideAtlasiE9PVP1
PRIDEiE9PVP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020017; ENSMUSP00000020017; ENSMUSG00000019866
GeneIDi11630
KEGGimmu:11630
UCSCiuc007ezq.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
202
MGIiMGI:109544 Crybg1

Phylogenomic databases

eggNOGiENOG410IERF Eukaryota
ENOG4110BHM LUCA
GeneTreeiENSGT00940000155695
InParanoidiE9PVP1
OrthoDBi89929at2759
TreeFamiTF331078

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019866 Expressed in 158 organ(s), highest expression level in substantia propria of cornea
ExpressionAtlasiE9PVP1 baseline and differential
GenevisibleiE9PVP1 MM

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00030 Crystall, 6 hits
PF00652 Ricin_B_lectin, 1 hit
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits
SUPFAMiSSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 11 hits
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PVP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PVP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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