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Protein
Submitted name:

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

Inpp4b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Type II inositol 3,4-bisphosphate 4-phosphataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Inpp4bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2158925 Inpp4b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei912 – 938HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037940 Expressed in 174 organ(s), highest expression level in lumbar subsegment of spinal cord

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4428 Eukaryota
ENOG410YV83 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157587

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02IJ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4

The PANTHER Classification System

More...
PANTHERi
PTHR12187 PTHR12187, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9PVM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIKEEGTSE EGQHFLPAAQ ANDPEDIQFT SIQKIPNEPQ LEFILACRDL
60 70 80 90 100
VAPVSDRKLN TVVQISVIHP VEQTLTRYSS TEIVEGTKDP LFLTGVTFPP
110 120 130 140 150
DYPIYEETRI KLTVYDVKDK SHDTIRTSVL PEHKDPLPEV ARSFLGCASF
160 170 180 190 200
KVGELLKSKE QLLSLSLRTS DGGKVVGTIE VSLVKMGEIE DGDTDHITTD
210 220 230 240 250
VQGQKCALMY ESTAPESLSG KENLPFMNAV LRNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QELKELGDLS PHWDNLRKNV
310 320 330 340 350
LSHCDQMVTM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PVNLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSSINQL QPLIATHADL LLTSASQRSP DSLKSSLKLL
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPNV STEEKSTQHD
510 520 530 540 550
TPQLRRQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAKVD KLIERDSHNE
560 570 580 590 600
EGAGGSSSKD GEADHTLEDS ITSHPREDWY EQLHPLILTL KECMGEVVNR
610 620 630 640 650
AKQSLTFVLL QELAYSLPQC LMLTLRRDIV FSQALAGLVC GFIIKLHTSL
660 670 680 690 700
HDPGFLQQLH TVGLIVQYEG LLSTYSDEIG MLEDMAVGIS DLRKVAFKIT
710 720 730 740 750
EATSNDVLPV LTGRREHYVV EVKLPATVFE SLPLQIKEGQ LLHVYPVLFN
760 770 780 790 800
VGINEQQTLA ERFGDVSLQE SINQENFELV QEYYSIFMEK MPPDYISHFQ
810 820 830 840 850
EQTDLKGLLD NLHQNIQAKK RKNVEIMWLA ATICRKLNGI RFTCCKSAKD
860 870 880 890 900
RTSMSVTLEQ CSILRDEHQL HKDFFIRALD CMRSRQTQGA LNESDDPETG
910 920 930 940
CLTDNKPTSR HFYPVALLLV SSHLLVVWLI LSLALLLAKY Q
Length:941
Mass (Da):106,414
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC371C94AA62AD1F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P1Y8INP4B_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
924Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WJC1F8WJC1_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
809Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3URI3Q3URI3_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
818Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVM1E9PVM1_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2C4E9Q2C4_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
633Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q7X1E9Q7X1_MOUSE
Type II inositol 3,4-bisphosphate 4...
Inpp4b
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC113041 Genomic DNA No translation available.
AC113085 Genomic DNA No translation available.
AC115778 Genomic DNA No translation available.
AC119279 Genomic DNA No translation available.
AC121136 Genomic DNA No translation available.
AC122751 Genomic DNA No translation available.
AC158353 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001284520.1, NM_001297591.1
XP_006530917.1, XM_006530854.2
XP_006530918.1, XM_006530855.2
XP_006530919.1, XM_006530856.2
XP_006530920.1, XM_006530857.3
XP_011246653.1, XM_011248351.2
XP_011246654.1, XM_011248352.2
XP_017168215.1, XM_017312726.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.324468

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000109852; ENSMUSP00000105478; ENSMUSG00000037940
ENSMUST00000217122; ENSMUSP00000150541; ENSMUSG00000037940

Database of genes from NCBI RefSeq genomes

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GeneIDi
234515

UCSC genome browser

More...
UCSCi
uc009mjf.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113041 Genomic DNA No translation available.
AC113085 Genomic DNA No translation available.
AC115778 Genomic DNA No translation available.
AC119279 Genomic DNA No translation available.
AC121136 Genomic DNA No translation available.
AC122751 Genomic DNA No translation available.
AC158353 Genomic DNA No translation available.
RefSeqiNP_001284520.1, NM_001297591.1
XP_006530917.1, XM_006530854.2
XP_006530918.1, XM_006530855.2
XP_006530919.1, XM_006530856.2
XP_006530920.1, XM_006530857.3
XP_011246653.1, XM_011248351.2
XP_011246654.1, XM_011248352.2
XP_017168215.1, XM_017312726.1
UniGeneiMm.324468

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109852; ENSMUSP00000105478; ENSMUSG00000037940
ENSMUST00000217122; ENSMUSP00000150541; ENSMUSG00000037940
GeneIDi234515
UCSCiuc009mjf.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8821
MGIiMGI:2158925 Inpp4b

Phylogenomic databases

eggNOGiKOG4428 Eukaryota
ENOG410YV83 LUCA
GeneTreeiENSGT00940000157587
OrthoDBiEOG091G02IJ

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Inpp4b mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037940 Expressed in 174 organ(s), highest expression level in lumbar subsegment of spinal cord

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR039034 INPP4
PANTHERiPTHR12187 PTHR12187, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PVM3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PVM3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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