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Entry version 69 (11 Dec 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Tetratricopeptide repeat protein 21B

Gene

Ttc21b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tetratricopeptide repeat protein 21BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttc21bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920918 Ttc21b

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PVK4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PVK4

PeptideAtlas

More...
PeptideAtlasi
E9PVK4

PRoteomics IDEntifications database

More...
PRIDEi
E9PVK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034848 Expressed in 236 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PVK4 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati108 – 141TPRPROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 357TPR_REGIONInterPro annotationAdd BLAST52
Repeati324 – 357TPRPROSITE-ProRule annotationAdd BLAST34
Domaini492 – 559TPR_REGIONInterPro annotationAdd BLAST68
Repeati492 – 525TPRPROSITE-ProRule annotationAdd BLAST34
Domaini616 – 984TPR_REGIONInterPro annotationAdd BLAST369
Repeati721 – 754TPRPROSITE-ProRule annotationAdd BLAST34
Repeati755 – 788TPRPROSITE-ProRule annotationAdd BLAST34
Repeati830 – 863TPRPROSITE-ProRule annotationAdd BLAST34
Repeati883 – 916TPRPROSITE-ProRule annotationAdd BLAST34
Repeati917 – 950TPRPROSITE-ProRule annotationAdd BLAST34
Repeati951 – 984TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1196 – 1263TPR_REGIONInterPro annotationAdd BLAST68
Repeati1196 – 1229TPRPROSITE-ProRule annotationAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEX1 Eukaryota
ENOG410XV69 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005979

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEWGQQA

Database of Orthologous Groups

More...
OrthoDBi
45918at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR040364 TTC21A/TTC21B

The PANTHER Classification System

More...
PANTHERi
PTHR14699 PTHR14699, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13174 TPR_6, 1 hit
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 10 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PVK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSQGLKTLI NYYCQERYYH HVLLVASEGM KKYSSDPVFR FYHAYGTLME
60 70 80 90 100
GKAQEALREF EAIKNKQDVS LCSLMALMYV HKMSPNPDRE AILELDTKMK
110 120 130 140 150
EQRKEAGRKA LYHAGLFLWH IGRHDKAREY IDRMSKMPHD SNEGPILKAW
160 170 180 190 200
LDITRGKEPY AKKALRYFEE GLQDGNDIFA LLGKVLCLEI RQNYSGALET
210 220 230 240 250
VSQIIVNFPS FLPAFEKKMK LQLALQDWDQ TVETAQRLLL QDNHNVEALR
260 270 280 290 300
MLALYYLCRE GDVEKAATKL ENLGNALDVM EPQNAQLFYK ITLAFSRTCG
310 320 330 340 350
RNQLILQKVQ SFLEKAFSLT PQQAEIATEL GYQMILQGKV KEAWKWYRTA
360 370 380 390 400
MTLNESNISA VTGLIRCQLI EGQLQDADQQ LEFFSEFQQS MGKSAELMYL
410 420 430 440 450
HAVLATKKNN RQDEVINLLN DVVNTHFSHL EDLPLGIQYF EKLNPDFLLE
460 470 480 490 500
VVTEYLNLCP IQPAGPGQPL SPVLRRCSSV LETIIRSVPG LPQAVFLMAK
510 520 530 540 550
VKYLSGDTEA AYNNLQHCLE HSPSYAEAHL LMAQVYLSQD KVKLCSQSLE
560 570 580 590 600
LCLSYNFNVR EYPLYHLIKA QSQKKMGEVA EAIKTLHMAM NLPGMRRSRA
610 620 630 640 650
SSKSKHRTEV DASHRLSIFL ELVEVHRLNG EQHEAAKVLQ DAIHEFSGTC
660 670 680 690 700
EELRVTIANA DLALAQGDTD RALSMLRNVT TEQPYFIEAK EKMADIYLKH
710 720 730 740 750
RKEKMLYITC YREIAERMPS PRSFLLLGDA YMNIQEPEEA IVAYEQALNQ
760 770 780 790 800
NPKDGTLARK IGKALVKTHN YSKAITYYEA ALKSGQQNCL CYDLAELLLR
810 820 830 840 850
LKLYEKAEKV LQHSLAHEPV SELSALMVDG RSQVLLAKVY SKMERPSDAI
860 870 880 890 900
AALQQARELQ ARILKRVQME QPDAVPSQKH FAAEICAEIA KHSAAQRDYE
910 920 930 940 950
KAITFYREAL VHCETDSKIM LELAQLYLAQ EDLDASLRHC ALLLQRDQDN
960 970 980 990 1000
EPATMLMADL MFRKQDYEQA VYHLQQLLDR KPDNFMTLSR LIDLLRRCGK
1010 1020 1030 1040 1050
LEDVPRFFLM AEKHNSRTKL EPGFQYCKGL HFWYTGEPND ALRHFNKARK
1060 1070 1080 1090 1100
DSDWGQNALY NMIEICLNPD NETIGGEVFE NLNGDLGTSP EKQESVQLAV
1110 1120 1130 1140 1150
RTAEKLLKEL KPQTVQGRLQ LRIMENCCLM ATKQKSSVEQ ALNTFTEIAA
1160 1170 1180 1190 1200
SEKDHIPALL GMATAYMILK QTPKARNQLK RIAKMPWNPI EAEDLEKSWL
1210 1220 1230 1240 1250
LLADIYIQSA KYDMAEELLK RCLCHNRSCC KAYEYMGYIM EKEQAYTDAA
1260
FNYEMAWKHS NQTNPAVGS
Length:1,269
Mass (Da):145,370
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA49954F2DEA0B1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q0HA38TT21B_MOUSE
Tetratricopeptide repeat protein 21...
Ttc21b Ift139, Kiaa1992, Thm1
1,315Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844526 Genomic DNA No translation available.
AL928586 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001277598.1, NM_001290669.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000125446; ENSMUSP00000131758; ENSMUSG00000034848

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73668

UCSC genome browser

More...
UCSCi
uc012bwg.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844526 Genomic DNA No translation available.
AL928586 Genomic DNA No translation available.
RefSeqiNP_001277598.1, NM_001290669.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiE9PVK4
MaxQBiE9PVK4
PeptideAtlasiE9PVK4
PRIDEiE9PVK4

Genome annotation databases

EnsembliENSMUST00000125446; ENSMUSP00000131758; ENSMUSG00000034848
GeneIDi73668
UCSCiuc012bwg.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79809
MGIiMGI:1920918 Ttc21b

Phylogenomic databases

eggNOGiENOG410IEX1 Eukaryota
ENOG410XV69 LUCA
GeneTreeiENSGT00390000005979
OMAiPEWGQQA
OrthoDBi45918at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ttc21b mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034848 Expressed in 236 organ(s), highest expression level in testis
ExpressionAtlasiE9PVK4 baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR040364 TTC21A/TTC21B
PANTHERiPTHR14699 PTHR14699, 1 hit
PfamiView protein in Pfam
PF13174 TPR_6, 1 hit
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 14 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 10 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PVK4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PVK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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