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Protein
Submitted name:

Cysteine-rich secretory protein 4

Gene

Crisp4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine-rich secretory protein 4Imported
Gene namesi
Name:Crisp4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1925331 Crisp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 63HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi264 ↔ 282PROSITE-ProRule annotation
Disulfide bondi273 ↔ 286PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PRIDEiE9PVG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000025774 Expressed in 8 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiE9PVG4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PVG4
SMRiE9PVG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 288ShKTInterPro annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
InParanoidiE9PVG4
KOiK19919
OrthoDBiEOG091G0D4V
TreeFamiTF316148

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR003582 ShKT_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS51670 SHKT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PVG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDIQPLSR PEDRCPPSPG ALCLSISSGH LGSRTPPSVF CTGMAVKFIL
60 70 80 90 100
LLFVAAFVPV VTIRPLKLDR ALYNKLITES QTEPQEEIVN THNAFRRKVS
110 120 130 140 150
PPARNMLKVS WSSAAAENAR ILARYCDKSD SDSLERRLPN TFCGENMLME
160 170 180 190 200
HYPSSWSKVI EIWFNESKYF KYGEWPSTDD DIETDHYTQM VWASTYLVGC
210 220 230 240 250
DVAACRRQKA ATYLYVCHYC HEGNHQDTLN MPYKEGSPCD DCPNNCEDGL
260 270 280 290
CTNPCIYYDE YNNCDTQVKL YGCSHPAVQP FCKASCLCTT EIK
Length:293
Mass (Da):33,169
Last modified:April 5, 2011 - v1
Checksum:iB54B1DA590F6AE0B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D259Q9D259_MOUSE
Cysteine-rich secretory protein
Crisp4
250Annotation score:
G5E862G5E862_MOUSE
Cysteine-rich secretory protein 4
Crisp4 mCG_20777
254Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161367 Genomic DNA No translation available.
RefSeqiNP_001333976.1, NM_001347047.1
UniGeneiMm.319913

Genome annotation databases

EnsembliENSMUST00000115344; ENSMUSP00000111001; ENSMUSG00000025774
GeneIDi78081
KEGGimmu:78081
UCSCiuc007akj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161367 Genomic DNA No translation available.
RefSeqiNP_001333976.1, NM_001347047.1
UniGeneiMm.319913

3D structure databases

ProteinModelPortaliE9PVG4
SMRiE9PVG4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9PVG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115344; ENSMUSP00000111001; ENSMUSG00000025774
GeneIDi78081
KEGGimmu:78081
UCSCiuc007akj.1 mouse

Organism-specific databases

CTDi78081
MGIiMGI:1925331 Crisp4

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
InParanoidiE9PVG4
KOiK19919
OrthoDBiEOG091G0D4V
TreeFamiTF316148

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025774 Expressed in 8 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiE9PVG4 baseline and differential

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR003582 ShKT_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PVG4_MOUSE
AccessioniPrimary (citable) accession number: E9PVG4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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