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Protein

Protocadherin-16

Gene

Dchs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-16
Alternative name(s):
Protein Dchs1
Protein dachsous homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dchs1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685011 Dchs1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 2933ExtracellularSequence analysisAdd BLAST2898
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2934 – 2954HelicalSequence analysisAdd BLAST21
Topological domaini2955 – 3291CytoplasmicSequence analysisAdd BLAST337

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. DCHS1 and FAT4 single mutants and DCHS1/FAT4 double mutants have similar phenotypes. Heterozygous mice lacking one DCHS1 allele exhibit mitral valve prolapse with posterior leaflet elongation, leaflet thickening, and myxomatous degeneration with increased proteoglycan accumulation in both mitral leaflets (PubMed:26258302).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042904536 – 3291Protocadherin-16Add BLAST3256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2354N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3048PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PVD3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PVD3

PeptideAtlas

More...
PeptideAtlasi
E9PVD3

PRoteomics IDEntifications database

More...
PRIDEi
E9PVD3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PVD3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PVD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all layers of the developing brain, with expression being most prominent at the ventricular margin. Expressed throughout cardiac development in the endothelial cells and interstitial cells of the developing valves (at protein level). Expression is observed in the endocardium and mesenchyme of the superior and inferior cushions at day E11.5. At days E13.5 and E15.5, expression is observed in the forming anterior and posterior mitral leaflets (PubMed:26258302).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036862 Expressed in 142 organ(s), highest expression level in internal carotid artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PVD3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PVD3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterophilic interaction with FAT4; this interaction affects their respective protein levels.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231434, 2 interactors

Protein interaction database and analysis system

More...
IntActi
E9PVD3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077574

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PVD3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 137Cadherin 1PROSITE-ProRule annotationAdd BLAST101
Domaini138 – 249Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini250 – 356Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini369 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST98
Domaini476 – 572Cadherin 5PROSITE-ProRule annotationAdd BLAST97
Domaini573 – 679Cadherin 6PROSITE-ProRule annotationAdd BLAST107
Domaini680 – 784Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini785 – 888Cadherin 8PROSITE-ProRule annotationAdd BLAST104
Domaini889 – 994Cadherin 9PROSITE-ProRule annotationAdd BLAST106
Domaini995 – 1105Cadherin 10PROSITE-ProRule annotationAdd BLAST111
Domaini1100 – 1205Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1218 – 1317Cadherin 12PROSITE-ProRule annotationAdd BLAST100
Domaini1326 – 1429Cadherin 13PROSITE-ProRule annotationAdd BLAST104
Domaini1430 – 1539Cadherin 14PROSITE-ProRule annotationAdd BLAST110
Domaini1539 – 1642Cadherin 15PROSITE-ProRule annotationAdd BLAST104
Domaini1643 – 1744Cadherin 16PROSITE-ProRule annotationAdd BLAST102
Domaini1745 – 1848Cadherin 17PROSITE-ProRule annotationAdd BLAST104
Domaini1849 – 1953Cadherin 18PROSITE-ProRule annotationAdd BLAST105
Domaini1976 – 2061Cadherin 19PROSITE-ProRule annotationAdd BLAST86
Domaini2062 – 2164Cadherin 20PROSITE-ProRule annotationAdd BLAST103
Domaini2165 – 2270Cadherin 21PROSITE-ProRule annotationAdd BLAST106
Domaini2270 – 2369Cadherin 22PROSITE-ProRule annotationAdd BLAST100
Domaini2370 – 2475Cadherin 23PROSITE-ProRule annotationAdd BLAST106
Domaini2476 – 2595Cadherin 24PROSITE-ProRule annotationAdd BLAST120
Domaini2596 – 2699Cadherin 25PROSITE-ProRule annotationAdd BLAST104
Domaini2700 – 2806Cadherin 26PROSITE-ProRule annotationAdd BLAST107
Domaini2807 – 2926Cadherin 27PROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PVD3

KEGG Orthology (KO)

More...
KOi
K16507

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFLQPHY

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 23 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 27 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 27 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 27 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PVD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKELSVALS CPGMKSLRTL LPLLVLLGAT VPGSWGQAGS LDLQIDEEQP
60 70 80 90 100
AGTLIGDISA GLPPGTAPPP MYFISAQEGS GVGTDLAIDE HSGVVRTARV
110 120 130 140 150
LDRERRDRYR FTAVTPDGAT VEVTVRVADI NDHAPAFPQA RAALQIPEHT
160 170 180 190 200
ALGTRYPLEP ARDADAGRLG TQGYALSGDG AGETFRLETR PGPGGAPVPE
210 220 230 240 250
LVIAGELDRE NRSHYMLQLE AYDGGSPPRR AQALLDVTLL DINDHAPAFN
260 270 280 290 300
QSRYHAVVSE SLAPGSPVLQ VFASDADAGA NGAVTYEINR RQSEGDGPFS
310 320 330 340 350
IDAHTGFLRL ERPLDFEQRR VHELVVQARD GGAHPELGSA FVTVHVRDAN
360 370 380 390 400
DNQPSMTVIF LSADGSPRVS EAAPPGQLVA RISVSDPDDG DFAHVNVSLE
410 420 430 440 450
GGEGHFALST QDSVIYLVCV ARRLDREERD VYNLRVTATD SGSPPLRAEA
460 470 480 490 500
AFVLHVTDVN DNAPAFDRQL YRPEPLPEVA LPGSFVVRVT ARDPDQGTNG
510 520 530 540 550
QITYSLAPGT HTHWFSIDPT SGIITTAATL DYELEPQPQL IVVATDGGLP
560 570 580 590 600
PLVSSATVSV ALQDVNDNEP QFQRTFYNAS LPEGTQPGTC FLQVTATDAD
610 620 630 640 650
SGPFGLLSYS LGAGLGASGS PPFRIDAHSG DVCTTRTLDR DQGPSSFDFT
660 670 680 690 700
VTAIDGGGLK SMVYVKVFVA DENDNPPQFY PREYAASLSA QSTPGTAVLR
710 720 730 740 750
VHAHDPDQGP HGRLSYHILA GNSPPLFALD AHSGLLTVAW PLGRRANSVV
760 770 780 790 800
QLEIGAQDGG GLQAEPIARV NISIVPGTPT PPIFEQLQYV FSVPEDVAPG
810 820 830 840 850
TSVGIIQAHN PPGRLGPVTL TLSGGDPRGL FSLDSPSGLL KTLRPLDREL
860 870 880 890 900
LGPVLELEVR AGSGTPPVFA VARIRVLLDD VNDNSPAFPA PEDTVLLPQN
910 920 930 940 950
TAPGTPIYTL RALDPDSGAN SRITFNLLAG GDGLFTVDPT TGHVRLMGPL
960 970 980 990 1000
GPPGGPAHEL EVEARDGGSP PRTSHFRLRV VIQDLGIHGL APRFDSPTYR
1010 1020 1030 1040 1050
VDLPSGTTTG TQILQVQAQA PDGSPVTYHL AADGASSPFG LESQSGWLWV
1060 1070 1080 1090 1100
RTALDRESQE LYTLKVMAVS GSKAELGQQT GTATVRVIIL NQNDHSPRLS
1110 1120 1130 1140 1150
EEPTFLAVAE NQPPGTSVGR VFATDRDSGP NGRLTYSLQQ LSEDSKAFRI
1160 1170 1180 1190 1200
HPQTGEVTTL QTLDREQQSS FQLLVQVQDG GSPPRSATGT VHVAVLDLND
1210 1220 1230 1240 1250
NSPTFLQASG AAGGGLPIQV PDRVPPGTLV TTLQAKDPDE GENGTILYTL
1260 1270 1280 1290 1300
TGPGSELFSL HPHTGELHTA ASLVRAERPH YVLTLSAHDQ GSPPRSASLQ
1310 1320 1330 1340 1350
LLVQVLPSTR VVESPDLIEA DSAATVPVVL TVTAAEGLRP GSLLGSVAPQ
1360 1370 1380 1390 1400
EPASVGVLTY TLVGGADPEG TFALDSASGR LYLARPLDFE AGPAWRALTV
1410 1420 1430 1440 1450
RAEGPGGAGA RLLRVQVRVQ DENEHAPTFA RDPLALALPE NPDPGATLYT
1460 1470 1480 1490 1500
FRASDADGPG PNSEVRYRLL RQEPPVPALR LDARTGALSA PRGLDRETTP
1510 1520 1530 1540 1550
ALLLLVEATD RPANASRRRA ARVSARVFVT DENDNAPVFA SPSRVRLPED
1560 1570 1580 1590 1600
QPPGPAALHV VARDPDLGEA ARVSYRLAAG GDGHFRLHAT TGALSVVRPL
1610 1620 1630 1640 1650
DREQRAEHVL TVVALDHGSP PRSSTQLLTV SVVDVNDEAP AFPQQEYNVI
1660 1670 1680 1690 1700
LRENSPPGTS LLTLKATDPD LGANGQVTYG GVSGESFSLD PNTGVLTTLR
1710 1720 1730 1740 1750
ALDREEQEEI YLTVYARDRG LPPLLTHITV RVTVEDENDH TPTFGNTHLS
1760 1770 1780 1790 1800
LEVPEGQDPQ TLTTLRASDP DGGLNGQLQY RILDGDSSGA FALDLTSGEF
1810 1820 1830 1840 1850
GTMRPLDREV EPAFQLQIEA RDGGQPALSA TLLVTVTVLD ANDHAPVFPV
1860 1870 1880 1890 1900
PSYSVEVPED APVGTLLLQL QAHDPDDGDN GRVMYYLGAG TAGAFLLEPT
1910 1920 1930 1940 1950
SGELSTATAL DREHCASYAF SVTAVDGAAA GPLSTTVPIT ITVRDVNDHA
1960 1970 1980 1990 2000
PAFPTSPLRL RLPRPGPSLN KPTLALATLR AEDRDAGANA SILYRLAGTP
2010 2020 2030 2040 2050
PPGTTVDSYT GEIRVARSPV ALGPQDRVLF IVATDLGRPA RSATGVVVVG
2060 2070 2080 2090 2100
IQGEPERGPR FPRTSSEAVL RENAPPGTPV ISPKAVHSGG SNGPITYSIL
2110 2120 2130 2140 2150
SGNERGIFSI QPSTGAITVR SAEGLDFETS PRLRLVLQAE SGGAFAFSVL
2160 2170 2180 2190 2200
TLTLQDANDN APRFLRPHYV AFLPESRPLE GPLLQVEADD LDQGSGGQIS
2210 2220 2230 2240 2250
YSLAASQPAR GLFHVDPATG TITTTAILDR EIWAETRLVL MATDRGSPAL
2260 2270 2280 2290 2300
VGSATLTVMV IDTNDNRPTI PQPWELRVSE DALLGSEIAQ VTGNDVDSGP
2310 2320 2330 2340 2350
VLWYVLSPSG PQDPFSIGRY GGRVSLTGPL DFEQCDHYHL QLLAHDGPHE
2360 2370 2380 2390 2400
GHANLTVLVE DVNDNVPTFS QSLYQVMMLE HTPPGSAILS VSATDRDSGA
2410 2420 2430 2440 2450
NGHISYHLAS PAEGFRVDPN NGTLFTTVGA MALGHEGPGV VDVVLEARDH
2460 2470 2480 2490 2500
GAPGRTAQAT VHVQLKDQND HAPSFTLPHY RVAVSEDLPP GSTLLTLEAT
2510 2520 2530 2540 2550
DADGSRTHAT VDYSIISGNR GRVFQLEPRL AEVGDGVGPG PQALGCLVLL
2560 2570 2580 2590 2600
EPLDFESLTQ YNLTVAAADR GQPPRSSAVP VTVTVLDVND NPPVFTRASY
2610 2620 2630 2640 2650
RVTVPEDMPV GAELLHVEAS DADPGPHGLV HFTLSSGDPL GLFELDENSG
2660 2670 2680 2690 2700
ALRLSRPLDC ETQAQHQLVV QAADPAGTHF SLVPVTVEVQ DVNDHGPAFP
2710 2720 2730 2740 2750
LSLLSTSLAE NQPPGTLVTT LHAIDGDAGT FGRLRYSLLE AVPGPEGREA
2760 2770 2780 2790 2800
FSLNSSTGEL RARVPFDYEH TGSFRLLVGA ADAGNLSASV TVSVLITGED
2810 2820 2830 2840 2850
EYDPVFLAPS FHFQVPEGAQ RGHSLGHVQA TDEDGGADGL VLYSLATSSP
2860 2870 2880 2890 2900
YFGINQTTGA LYLRVDSRAP GSGTTTSGGG GRTRREAPRE LRLEVVARGP
2910 2920 2930 2940 2950
LPGSRSATVP VTVDITHTAL GLAPDLNLLL VGAVAASLGV VVVLALAALV
2960 2970 2980 2990 3000
LGLVRARSRK AEAAPGPMSQ TAPIASSSLQ KLGREPPSPP PSEHLYHQTL
3010 3020 3030 3040 3050
PSYGGPGAGG PYPRGGSLDP SHSSGRGSAE AAEDDEIRMI NEFPRVASVA
3060 3070 3080 3090 3100
SSLAARGPDS GIQQDADGLS DTSCEPPAPD TWYKGRKAGL LLPGAGATLY
3110 3120 3130 3140 3150
REEGPPATAT AFLGGCGLSP APAGDYGFPA DGKPCVAGAL TAIVAGEEEL
3160 3170 3180 3190 3200
RGSYNWDYLL SWCPQFQPLA SVFTEIARLK DEARPCPPAP RIDPPPLITA
3210 3220 3230 3240 3250
VAHPGAKSVP PKPASTAVAR AIFPPASHRS PISHEGSLSS AAMSPSFSPS
3260 3270 3280 3290
LSPLAARSPV VSPFGVAQGP SASALSTESG LEPPDDTELR I
Length:3,291
Mass (Da):346,384
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C0C1E720AE82BE3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSA3A0A1B0GSA3_MOUSE
Protocadherin-16
Dchs1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC121823 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS52351.1

NCBI Reference Sequences

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RefSeqi
NP_001156415.1, NM_001162943.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.334108

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000078482; ENSMUSP00000077574; ENSMUSG00000036862

Database of genes from NCBI RefSeq genomes

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GeneIDi
233651

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:233651

UCSC genome browser

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UCSCi
uc009izh.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121823 Genomic DNA No translation available.
CCDSiCCDS52351.1
RefSeqiNP_001156415.1, NM_001162943.1
UniGeneiMm.334108

3D structure databases

SMRiE9PVD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231434, 2 interactors
IntActiE9PVD3, 1 interactor
STRINGi10090.ENSMUSP00000077574

PTM databases

iPTMnetiE9PVD3
PhosphoSitePlusiE9PVD3

Proteomic databases

MaxQBiE9PVD3
PaxDbiE9PVD3
PeptideAtlasiE9PVD3
PRIDEiE9PVD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078482; ENSMUSP00000077574; ENSMUSG00000036862
GeneIDi233651
KEGGimmu:233651
UCSCiuc009izh.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8642
MGIiMGI:2685011 Dchs1

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000161822
InParanoidiE9PVD3
KOiK16507
OMAiRFLQPHY
OrthoDBi34489at2759
TreeFamiTF316403

Miscellaneous databases

Protein Ontology

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PROi
PR:E9PVD3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036862 Expressed in 142 organ(s), highest expression level in internal carotid artery
ExpressionAtlasiE9PVD3 baseline and differential
GenevisibleiE9PVD3 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 23 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 27 hits
SUPFAMiSSF49313 SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 27 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCD16_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PVD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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