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Protein

Protocadherin-16

Gene

Dchs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-16
Alternative name(s):
Protein Dchs1
Protein dachsous homolog 1
Gene namesi
Name:Dchs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685011 Dchs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 2933ExtracellularSequence analysisAdd BLAST2898
Transmembranei2934 – 2954HelicalSequence analysisAdd BLAST21
Topological domaini2955 – 3291CytoplasmicSequence analysisAdd BLAST337

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. DCHS1 and FAT4 single mutants and DCHS1/FAT4 double mutants have similar phenotypes. Heterozygous mice lacking one DCHS1 allele exhibit mitral valve prolapse with posterior leaflet elongation, leaflet thickening, and myxomatous degeneration with increased proteoglycan accumulation in both mitral leaflets (PubMed:26258302).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000042904536 – 3291Protocadherin-16Add BLAST3256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2354N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3048PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiE9PVD3
PaxDbiE9PVD3
PeptideAtlasiE9PVD3
PRIDEiE9PVD3

PTM databases

iPTMnetiE9PVD3
PhosphoSitePlusiE9PVD3

Expressioni

Tissue specificityi

Developmental stagei

Expressed in all layers of the developing brain, with expression being most prominent at the ventricular margin. Expressed throughout cardiac development in the endothelial cells and interstitial cells of the developing valves (at protein level). Expression is observed in the endocardium and mesenchyme of the superior and inferior cushions at day E11.5. At days E13.5 and E15.5, expression is observed in the forming anterior and posterior mitral leaflets (PubMed:26258302).2 Publications

Gene expression databases

BgeeiENSMUSG00000036862 Expressed in 142 organ(s), highest expression level in internal carotid artery
ExpressionAtlasiE9PVD3 baseline and differential
GenevisibleiE9PVD3 MM

Interactioni

Subunit structurei

Heterophilic interaction with FAT4; this interaction affects their respective protein levels.

Protein-protein interaction databases

BioGridi231434, 2 interactors
IntActiE9PVD3, 1 interactor
STRINGi10090.ENSMUSP00000077574

Structurei

3D structure databases

SMRiE9PVD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 137Cadherin 1PROSITE-ProRule annotationAdd BLAST101
Domaini138 – 249Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini250 – 356Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini369 – 466Cadherin 4PROSITE-ProRule annotationAdd BLAST98
Domaini476 – 572Cadherin 5PROSITE-ProRule annotationAdd BLAST97
Domaini573 – 679Cadherin 6PROSITE-ProRule annotationAdd BLAST107
Domaini680 – 784Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini785 – 888Cadherin 8PROSITE-ProRule annotationAdd BLAST104
Domaini889 – 994Cadherin 9PROSITE-ProRule annotationAdd BLAST106
Domaini995 – 1105Cadherin 10PROSITE-ProRule annotationAdd BLAST111
Domaini1100 – 1205Cadherin 11PROSITE-ProRule annotationAdd BLAST106
Domaini1218 – 1317Cadherin 12PROSITE-ProRule annotationAdd BLAST100
Domaini1326 – 1429Cadherin 13PROSITE-ProRule annotationAdd BLAST104
Domaini1430 – 1539Cadherin 14PROSITE-ProRule annotationAdd BLAST110
Domaini1539 – 1642Cadherin 15PROSITE-ProRule annotationAdd BLAST104
Domaini1643 – 1744Cadherin 16PROSITE-ProRule annotationAdd BLAST102
Domaini1745 – 1848Cadherin 17PROSITE-ProRule annotationAdd BLAST104
Domaini1849 – 1953Cadherin 18PROSITE-ProRule annotationAdd BLAST105
Domaini1976 – 2061Cadherin 19PROSITE-ProRule annotationAdd BLAST86
Domaini2062 – 2164Cadherin 20PROSITE-ProRule annotationAdd BLAST103
Domaini2165 – 2270Cadherin 21PROSITE-ProRule annotationAdd BLAST106
Domaini2270 – 2369Cadherin 22PROSITE-ProRule annotationAdd BLAST100
Domaini2370 – 2475Cadherin 23PROSITE-ProRule annotationAdd BLAST106
Domaini2476 – 2595Cadherin 24PROSITE-ProRule annotationAdd BLAST120
Domaini2596 – 2699Cadherin 25PROSITE-ProRule annotationAdd BLAST104
Domaini2700 – 2806Cadherin 26PROSITE-ProRule annotationAdd BLAST107
Domaini2807 – 2926Cadherin 27PROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00760000118805
InParanoidiE9PVD3
KOiK16507
OMAiRFLQPHY
OrthoDBiEOG091G0028
TreeFamiTF316403

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 23 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 27 hits
SUPFAMiSSF49313 SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 27 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PVD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKELSVALS CPGMKSLRTL LPLLVLLGAT VPGSWGQAGS LDLQIDEEQP
60 70 80 90 100
AGTLIGDISA GLPPGTAPPP MYFISAQEGS GVGTDLAIDE HSGVVRTARV
110 120 130 140 150
LDRERRDRYR FTAVTPDGAT VEVTVRVADI NDHAPAFPQA RAALQIPEHT
160 170 180 190 200
ALGTRYPLEP ARDADAGRLG TQGYALSGDG AGETFRLETR PGPGGAPVPE
210 220 230 240 250
LVIAGELDRE NRSHYMLQLE AYDGGSPPRR AQALLDVTLL DINDHAPAFN
260 270 280 290 300
QSRYHAVVSE SLAPGSPVLQ VFASDADAGA NGAVTYEINR RQSEGDGPFS
310 320 330 340 350
IDAHTGFLRL ERPLDFEQRR VHELVVQARD GGAHPELGSA FVTVHVRDAN
360 370 380 390 400
DNQPSMTVIF LSADGSPRVS EAAPPGQLVA RISVSDPDDG DFAHVNVSLE
410 420 430 440 450
GGEGHFALST QDSVIYLVCV ARRLDREERD VYNLRVTATD SGSPPLRAEA
460 470 480 490 500
AFVLHVTDVN DNAPAFDRQL YRPEPLPEVA LPGSFVVRVT ARDPDQGTNG
510 520 530 540 550
QITYSLAPGT HTHWFSIDPT SGIITTAATL DYELEPQPQL IVVATDGGLP
560 570 580 590 600
PLVSSATVSV ALQDVNDNEP QFQRTFYNAS LPEGTQPGTC FLQVTATDAD
610 620 630 640 650
SGPFGLLSYS LGAGLGASGS PPFRIDAHSG DVCTTRTLDR DQGPSSFDFT
660 670 680 690 700
VTAIDGGGLK SMVYVKVFVA DENDNPPQFY PREYAASLSA QSTPGTAVLR
710 720 730 740 750
VHAHDPDQGP HGRLSYHILA GNSPPLFALD AHSGLLTVAW PLGRRANSVV
760 770 780 790 800
QLEIGAQDGG GLQAEPIARV NISIVPGTPT PPIFEQLQYV FSVPEDVAPG
810 820 830 840 850
TSVGIIQAHN PPGRLGPVTL TLSGGDPRGL FSLDSPSGLL KTLRPLDREL
860 870 880 890 900
LGPVLELEVR AGSGTPPVFA VARIRVLLDD VNDNSPAFPA PEDTVLLPQN
910 920 930 940 950
TAPGTPIYTL RALDPDSGAN SRITFNLLAG GDGLFTVDPT TGHVRLMGPL
960 970 980 990 1000
GPPGGPAHEL EVEARDGGSP PRTSHFRLRV VIQDLGIHGL APRFDSPTYR
1010 1020 1030 1040 1050
VDLPSGTTTG TQILQVQAQA PDGSPVTYHL AADGASSPFG LESQSGWLWV
1060 1070 1080 1090 1100
RTALDRESQE LYTLKVMAVS GSKAELGQQT GTATVRVIIL NQNDHSPRLS
1110 1120 1130 1140 1150
EEPTFLAVAE NQPPGTSVGR VFATDRDSGP NGRLTYSLQQ LSEDSKAFRI
1160 1170 1180 1190 1200
HPQTGEVTTL QTLDREQQSS FQLLVQVQDG GSPPRSATGT VHVAVLDLND
1210 1220 1230 1240 1250
NSPTFLQASG AAGGGLPIQV PDRVPPGTLV TTLQAKDPDE GENGTILYTL
1260 1270 1280 1290 1300
TGPGSELFSL HPHTGELHTA ASLVRAERPH YVLTLSAHDQ GSPPRSASLQ
1310 1320 1330 1340 1350
LLVQVLPSTR VVESPDLIEA DSAATVPVVL TVTAAEGLRP GSLLGSVAPQ
1360 1370 1380 1390 1400
EPASVGVLTY TLVGGADPEG TFALDSASGR LYLARPLDFE AGPAWRALTV
1410 1420 1430 1440 1450
RAEGPGGAGA RLLRVQVRVQ DENEHAPTFA RDPLALALPE NPDPGATLYT
1460 1470 1480 1490 1500
FRASDADGPG PNSEVRYRLL RQEPPVPALR LDARTGALSA PRGLDRETTP
1510 1520 1530 1540 1550
ALLLLVEATD RPANASRRRA ARVSARVFVT DENDNAPVFA SPSRVRLPED
1560 1570 1580 1590 1600
QPPGPAALHV VARDPDLGEA ARVSYRLAAG GDGHFRLHAT TGALSVVRPL
1610 1620 1630 1640 1650
DREQRAEHVL TVVALDHGSP PRSSTQLLTV SVVDVNDEAP AFPQQEYNVI
1660 1670 1680 1690 1700
LRENSPPGTS LLTLKATDPD LGANGQVTYG GVSGESFSLD PNTGVLTTLR
1710 1720 1730 1740 1750
ALDREEQEEI YLTVYARDRG LPPLLTHITV RVTVEDENDH TPTFGNTHLS
1760 1770 1780 1790 1800
LEVPEGQDPQ TLTTLRASDP DGGLNGQLQY RILDGDSSGA FALDLTSGEF
1810 1820 1830 1840 1850
GTMRPLDREV EPAFQLQIEA RDGGQPALSA TLLVTVTVLD ANDHAPVFPV
1860 1870 1880 1890 1900
PSYSVEVPED APVGTLLLQL QAHDPDDGDN GRVMYYLGAG TAGAFLLEPT
1910 1920 1930 1940 1950
SGELSTATAL DREHCASYAF SVTAVDGAAA GPLSTTVPIT ITVRDVNDHA
1960 1970 1980 1990 2000
PAFPTSPLRL RLPRPGPSLN KPTLALATLR AEDRDAGANA SILYRLAGTP
2010 2020 2030 2040 2050
PPGTTVDSYT GEIRVARSPV ALGPQDRVLF IVATDLGRPA RSATGVVVVG
2060 2070 2080 2090 2100
IQGEPERGPR FPRTSSEAVL RENAPPGTPV ISPKAVHSGG SNGPITYSIL
2110 2120 2130 2140 2150
SGNERGIFSI QPSTGAITVR SAEGLDFETS PRLRLVLQAE SGGAFAFSVL
2160 2170 2180 2190 2200
TLTLQDANDN APRFLRPHYV AFLPESRPLE GPLLQVEADD LDQGSGGQIS
2210 2220 2230 2240 2250
YSLAASQPAR GLFHVDPATG TITTTAILDR EIWAETRLVL MATDRGSPAL
2260 2270 2280 2290 2300
VGSATLTVMV IDTNDNRPTI PQPWELRVSE DALLGSEIAQ VTGNDVDSGP
2310 2320 2330 2340 2350
VLWYVLSPSG PQDPFSIGRY GGRVSLTGPL DFEQCDHYHL QLLAHDGPHE
2360 2370 2380 2390 2400
GHANLTVLVE DVNDNVPTFS QSLYQVMMLE HTPPGSAILS VSATDRDSGA
2410 2420 2430 2440 2450
NGHISYHLAS PAEGFRVDPN NGTLFTTVGA MALGHEGPGV VDVVLEARDH
2460 2470 2480 2490 2500
GAPGRTAQAT VHVQLKDQND HAPSFTLPHY RVAVSEDLPP GSTLLTLEAT
2510 2520 2530 2540 2550
DADGSRTHAT VDYSIISGNR GRVFQLEPRL AEVGDGVGPG PQALGCLVLL
2560 2570 2580 2590 2600
EPLDFESLTQ YNLTVAAADR GQPPRSSAVP VTVTVLDVND NPPVFTRASY
2610 2620 2630 2640 2650
RVTVPEDMPV GAELLHVEAS DADPGPHGLV HFTLSSGDPL GLFELDENSG
2660 2670 2680 2690 2700
ALRLSRPLDC ETQAQHQLVV QAADPAGTHF SLVPVTVEVQ DVNDHGPAFP
2710 2720 2730 2740 2750
LSLLSTSLAE NQPPGTLVTT LHAIDGDAGT FGRLRYSLLE AVPGPEGREA
2760 2770 2780 2790 2800
FSLNSSTGEL RARVPFDYEH TGSFRLLVGA ADAGNLSASV TVSVLITGED
2810 2820 2830 2840 2850
EYDPVFLAPS FHFQVPEGAQ RGHSLGHVQA TDEDGGADGL VLYSLATSSP
2860 2870 2880 2890 2900
YFGINQTTGA LYLRVDSRAP GSGTTTSGGG GRTRREAPRE LRLEVVARGP
2910 2920 2930 2940 2950
LPGSRSATVP VTVDITHTAL GLAPDLNLLL VGAVAASLGV VVVLALAALV
2960 2970 2980 2990 3000
LGLVRARSRK AEAAPGPMSQ TAPIASSSLQ KLGREPPSPP PSEHLYHQTL
3010 3020 3030 3040 3050
PSYGGPGAGG PYPRGGSLDP SHSSGRGSAE AAEDDEIRMI NEFPRVASVA
3060 3070 3080 3090 3100
SSLAARGPDS GIQQDADGLS DTSCEPPAPD TWYKGRKAGL LLPGAGATLY
3110 3120 3130 3140 3150
REEGPPATAT AFLGGCGLSP APAGDYGFPA DGKPCVAGAL TAIVAGEEEL
3160 3170 3180 3190 3200
RGSYNWDYLL SWCPQFQPLA SVFTEIARLK DEARPCPPAP RIDPPPLITA
3210 3220 3230 3240 3250
VAHPGAKSVP PKPASTAVAR AIFPPASHRS PISHEGSLSS AAMSPSFSPS
3260 3270 3280 3290
LSPLAARSPV VSPFGVAQGP SASALSTESG LEPPDDTELR I
Length:3,291
Mass (Da):346,384
Last modified:April 5, 2011 - v1
Checksum:i0C0C1E720AE82BE3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSA3A0A1B0GSA3_MOUSE
Protocadherin-16
Dchs1
50Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121823 Genomic DNA No translation available.
CCDSiCCDS52351.1
RefSeqiNP_001156415.1, NM_001162943.1
UniGeneiMm.334108

Genome annotation databases

EnsembliENSMUST00000078482; ENSMUSP00000077574; ENSMUSG00000036862
GeneIDi233651
KEGGimmu:233651
UCSCiuc009izh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121823 Genomic DNA No translation available.
CCDSiCCDS52351.1
RefSeqiNP_001156415.1, NM_001162943.1
UniGeneiMm.334108

3D structure databases

SMRiE9PVD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231434, 2 interactors
IntActiE9PVD3, 1 interactor
STRINGi10090.ENSMUSP00000077574

PTM databases

iPTMnetiE9PVD3
PhosphoSitePlusiE9PVD3

Proteomic databases

MaxQBiE9PVD3
PaxDbiE9PVD3
PeptideAtlasiE9PVD3
PRIDEiE9PVD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078482; ENSMUSP00000077574; ENSMUSG00000036862
GeneIDi233651
KEGGimmu:233651
UCSCiuc009izh.2 mouse

Organism-specific databases

CTDi8642
MGIiMGI:2685011 Dchs1

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00760000118805
InParanoidiE9PVD3
KOiK16507
OMAiRFLQPHY
OrthoDBiEOG091G0028
TreeFamiTF316403

Miscellaneous databases

PROiPR:E9PVD3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036862 Expressed in 142 organ(s), highest expression level in internal carotid artery
ExpressionAtlasiE9PVD3 baseline and differential
GenevisibleiE9PVD3 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 23 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 27 hits
SUPFAMiSSF49313 SSF49313, 27 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 18 hits
PS50268 CADHERIN_2, 27 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD16_MOUSE
AccessioniPrimary (citable) accession number: E9PVD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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