Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 62 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Multiple C2 and transmembrane domain-containing protein 1

Gene

Mctp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds Ca2+ via the C2 domains in absence of phospholipids.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple C2 and transmembrane domain-containing protein 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mctp1Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926021 Mctp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Transmembranei866 – 886HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004417111 – 951Multiple C2 and transmembrane domain-containing protein 1Add BLAST951

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PV86

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PV86

PeptideAtlas

More...
PeptideAtlasi
E9PV86

PRoteomics IDEntifications database

More...
PRIDEi
E9PV86

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PV86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PV86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021596 Expressed in 100 organ(s), highest expression level in dorsal striatum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PV86 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105212

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9PV86

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PV86

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini246 – 342C2 1PROSITE-ProRule annotationAdd BLAST97
Domaini409 – 505C2 2PROSITE-ProRule annotationAdd BLAST97
Domaini565 – 660C2 3PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi151 – 168Ser-richPROSITE-ProRule annotationAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCTP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1030 Eukaryota
COG5038 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156031

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PV86

Database of Orthologous Groups

More...
OrthoDBi
234298at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323373

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR013583 PRibTrfase_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 3 hits
PF08372 PRT_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PV86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRAATTGE LVRAASPSFQ ARLWKNLQLG VGKGKGGGGG RAGGPEHRTA
60 70 80 90 100
ATPTPSPPPP GTTQDALAGV GSTGSRWSGF KKRKQVLDRV FSSSQPNLCC
110 120 130 140 150
SSPEPLEPGG AGRAEQGSTL RRRLREHLLP VAKGSSTATG TGGVTPPGGR
160 170 180 190 200
SPDSAPSSSS ASSSLSSSPQ PPPRGDRVRD ESTRRGGPGV HLCHQKSSSL
210 220 230 240 250
PGTACLEQLL EPAPPPAEPA RGPAEPQALQ KDIERDCSQK ISTVGNSNAD
260 270 280 290 300
VPLADPGMYQ LDITLRRGQS LAARDRGGTS DPYVKFKIGR KEVFRSKIIH
310 320 330 340 350
KNLNPVWEEK ACVLIDHLRE PLYIKVFDYD FGLQDDFMGS AFLDLTQLEL
360 370 380 390 400
NRSTDVTLTL KDPHYPDHDL GIILLSVILT PKEGEHRDVT MLMRKSWKRS
410 420 430 440 450
SKFQTQSLRL SDQHRKSHLW RGIVSITLIE GRDLKAMDSN GLSDPYVKFR
460 470 480 490 500
LGHQKYKSKI MPKTLNPQWR EQFDFHLYEE RGGIMDITAW DKDAGKRDDF
510 520 530 540 550
IGRCQVDLSS LSREQTHKLE LHLEEGEGHL VLLVTLTASA TVCISDLSVN
560 570 580 590 600
SMEDQKEREE ILKRYSPLRI FNNLKDVGFL QVKVIRAEGL MAADVTGKSD
610 620 630 640 650
PFCVVELNND RLLTHTVYKN LNPEWNKVFT FNIKDIHSVL EVTVYDEDRD
660 670 680 690 700
RSADFLGRVA IPLLSIQNGE QKAYVLKNKQ LTGPTKGVIY LEIDVIFNAV
710 720 730 740 750
KASLRTLIPK ERKYIEEENR LSKQLLLRNF IRTKRCVIVL VNAAYYVNSC
760 770 780 790 800
FDWDSPPRSL AAFVLFLLIV WNFELYMIPL LLLLLLTWNY FLIISGKDNR
810 820 830 840 850
QRDTVVEDML EDEEEEDDRD DKDGEKKGFI NKIYAIQEVC VSVQNILDEV
860 870 880 890 900
ASLGERIKNT FNWTVPFLSW LAIVALCVFT AILYFIPLRY IVLVWGINKF
910 920 930 940 950
TKKLRSPYAI DNNELLDFLS RVPSDVQVVQ YQELKPDHSH SPYKRKKNNL

G
Length:951
Mass (Da):106,795
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8E942F4F2B49460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW38E9PW38_MOUSE
Multiple C2 and transmembrane domai...
Mctp1
694Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1Y4E9Q1Y4_MOUSE
Multiple C2 and transmembrane domai...
Mctp1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYR7E9PYR7_MOUSE
Multiple C2 and transmembrane domai...
Mctp1
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC112671 Genomic DNA No translation available.
AC124362 Genomic DNA No translation available.
AC140345 Genomic DNA No translation available.
AC154788 Genomic DNA No translation available.
AC161266 Genomic DNA No translation available.
CT009761 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017171131.1, XM_017315642.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.316249

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000125209; ENSMUSP00000118958; ENSMUSG00000021596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78771

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112671 Genomic DNA No translation available.
AC124362 Genomic DNA No translation available.
AC140345 Genomic DNA No translation available.
AC154788 Genomic DNA No translation available.
AC161266 Genomic DNA No translation available.
CT009761 Genomic DNA No translation available.
RefSeqiXP_017171131.1, XM_017315642.1
UniGeneiMm.316249

3D structure databases

ProteinModelPortaliE9PV86
SMRiE9PV86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105212

PTM databases

iPTMnetiE9PV86
PhosphoSitePlusiE9PV86

Proteomic databases

MaxQBiE9PV86
PaxDbiE9PV86
PeptideAtlasiE9PV86
PRIDEiE9PV86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000125209; ENSMUSP00000118958; ENSMUSG00000021596
GeneIDi78771

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79772
MGIiMGI:1926021 Mctp1

Phylogenomic databases

eggNOGiKOG1030 Eukaryota
COG5038 LUCA
GeneTreeiENSGT00940000156031
InParanoidiE9PV86
OrthoDBi234298at2759
TreeFamiTF323373

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9PV86

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021596 Expressed in 100 organ(s), highest expression level in dorsal striatum
ExpressionAtlasiE9PV86 baseline and differential

Family and domain databases

Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR013583 PRibTrfase_C
PfamiView protein in Pfam
PF00168 C2, 3 hits
PF08372 PRT_C, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 3 hits
PROSITEiView protein in PROSITE
PS50004 C2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCTP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PV86
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again