Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Myosin XVIIIb

Gene

Myo18b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi700 – 707ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle fiber development Source: MGI
  • in utero embryonic development Source: MGI
  • vasculogenesis Source: MGI

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin XVIIIbImported
Gene namesi
Name:Myo18bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921626 Myo18b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE9PV66
PRIDEiE9PV66

PTM databases

iPTMnetiE9PV66
PhosphoSitePlusiE9PV66

Expressioni

Gene expression databases

BgeeiENSMUSG00000072720 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiE9PV66 baseline and differential
GenevisibleiE9PV66 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9PV66, 1 interactor
STRINGi10090.ENSMUSP00000083810

Structurei

3D structure databases

SMRiE9PV66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini611 – 1373Myosin motorInterPro annotationAdd BLAST763

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1444 – 1485Sequence analysisAdd BLAST42
Coiled coili1497 – 1548Sequence analysisAdd BLAST52
Coiled coili1555 – 1617Sequence analysisAdd BLAST63
Coiled coili1625 – 1652Sequence analysisAdd BLAST28
Coiled coili1674 – 1715Sequence analysisAdd BLAST42
Coiled coili1744 – 1814Sequence analysisAdd BLAST71
Coiled coili1870 – 1893Sequence analysisAdd BLAST24
Coiled coili1929 – 1956Sequence analysisAdd BLAST28
Coiled coili1964 – 1998Sequence analysisAdd BLAST35
Coiled coili2054 – 2095Sequence analysisAdd BLAST42
Coiled coili2103 – 2123Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150860
InParanoidiE9PV66
KOiK10362
OMAiAPEDRWY
OrthoDBiEOG091G00GA
PhylomeDBiE9PV66
TreeFamiTF339614

Family and domain databases

CDDicd01386 MYSc_Myo18, 1 hit
Gene3Di3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR028561 MYO18B
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR002928 Myosin_tail
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase
PANTHERiPTHR13140:SF372 PTHR13140:SF372, 1 hit
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9PV66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRETEKESK
60 70 80 90 100
EARRRKAAAF TAPEVEIPAV PTNQTNKTNN VPKPGSQQTS QDSSSTTQNS
110 120 130 140 150
ADIPGKEPPG AGDKDSTPVT STSGERPQES GPTGTPAKRT LPFKRGVRRG
160 170 180 190 200
DVLLMVAKLD PELAKADQKV QPRDVPVDKT PAPAKDSGGT KKGVTTGTSS
210 220 230 240 250
APQPSMPEKT RTRGVGDTGQ STKGGKCQGT EGKGSRDPQT IGQKEGESQS
260 270 280 290 300
TEEQGTRSQA QEAGNKEQLG TAEKEGGGPP KKMEKEDEPK VAGAEVRPVE
310 320 330 340 350
PPVPLRKWGG FLGWRSKWDS PQSKDRVTES HRKDEKTGDL QSPAVDRSCG
360 370 380 390 400
QLAEPTGQPS GPTGQPSGPT GQLSESTGQP SGPTGQPAGP TGQPAGPTGQ
410 420 430 440 450
PAGPTGQPAG PTGQQQEAPV KMEGKVGRPQ KKLVTPRKPR ELPGVAAKTQ
460 470 480 490 500
NPEESCKAPD RIPTTGISAE AAKRDGQPES RVQGAGEPRV CTEEEVDVVK
510 520 530 540 550
PQAEGHVESI PEVVMERLST LRPMEEKQIL QDPDRGGQSG DSDQAYEDRW
560 570 580 590 600
YEAQKVWLVQ KDGFTLATVL KPDEGTADPP AGRVRLCIDA DRTVIEVDEE
610 620 630 640 650
QVHPANPSEL DQAEDLASLV SVNESSVMNT LLQRYRAQLP YTCSGPDLIT
660 670 680 690 700
LQPQTTTVPS SGKVPRGRQD GLPAHVTSLA QRAYWALLSQ RRDQSIVALG
710 720 730 740 750
RSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKLRATFTVL RAFGCVSTGH
760 770 780 790 800
SRRATRFAMV MSLDFNATGR VTAAQLQTVL LENSRVARQP QGEGNFEVFS
810 820 830 840 850
QLLAGMDVDL RTELNLHQMA ESSAFGMGLW SKPEDKQKAA TAFSQLRGAM
860 870 880 890 900
ELLGISEGEQ QAIWRVLAAI YHLGAAGACK VGRKQFMRFE WANHAAEALG
910 920 930 940 950
CDYEELNTAT FKHHLRQIIE QMTSGPQRQG LQDNEACSGL KMTGVECVEG
960 970 980 990 1000
MASGLYQELF VAVVSLINRS FSSHHLSMAS IMVVDTPGFQ NPRHQGKDRA
1010 1020 1030 1040 1050
ATFEELCYNY AQERLQLLFY HRTFVSTLER YKEEGIPVPF DLPESSPGTT
1060 1070 1080 1090 1100
VAVVDQNPSQ VHLPAGRGAE DAGGLFWVLD EEVRVQGSSD STVLERLRAA
1110 1120 1130 1140 1150
FEKKKEAGAE EPPSMRTCEQ PLQCELFHQL GRDPVRYDLT GWLRRAKPNL
1160 1170 1180 1190 1200
AALEAPQILQ QSKREELQSL FQARAKLPPV CRAVAGLEGT SQQALHRSRV
1210 1220 1230 1240 1250
VRRAFASSLA AVKRKAPCAQ IKLQMDALIS LLRRSRLHFI HCLVPTTVES
1260 1270 1280 1290 1300
KAGQRTPSPS QPSGDQGVAN EPTALDIPAL RVQLAGSHIL EALRLHRAGY
1310 1320 1330 1340 1350
AEHMGLAQFR RRFQVLDPAL LKKLDLTSEE LDERKVVEEL LKTLDLEKKA
1360 1370 1380 1390 1400
VAVGHSQVFL KAGVVSRLER QREKLVSRNI VLFQAACRGF LSRQEYKKLK
1410 1420 1430 1440 1450
IRRLATLCIQ KNLAVFLKVK DWPWWGLLAS LRPLLSSTLG TEQLRAKEEE
1460 1470 1480 1490 1500
LTLLRQKLQK SENSRSELRQ NTDLLESKIT DLTSELADER FKGDVACQAL
1510 1520 1530 1540 1550
ESERAERLQA LREVQELKTK YQQVQDALGE VQKQLEEAQQ RIQGANLEEK
1560 1570 1580 1590 1600
PAGGADEWQM RLDCAQMEND FLRKRLQQCE ERLDSEMKAR TELEQKLGEL
1610 1620 1630 1640 1650
QSAYEEAKKM AHQLKRKCHH LTWDLEDTRV LLENQQSRNH ELEKRQKKFD
1660 1670 1680 1690 1700
LQLAQALGES MFEKSLREKV SQENNGVRWE LGQLQQQLEQ KEQEASKLKQ
1710 1720 1730 1740 1750
EVERLQGQKR ELLSCASVGD QGVASLKERV WELETNALEQ QKIHSQQENT
1760 1770 1780 1790 1800
IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC QKRLRQLEMQ
1810 1820 1830 1840 1850
LEQEYEEKQV ALHEKHDLEG LIGTLCDQIG HRDFDVEKRL RRDLRRTHAL
1860 1870 1880 1890 1900
LSDVQLLLAT IEDSKTSISK EELEKVHSQL EQSEAKCEDA LKTQKVLTAD
1910 1920 1930 1940 1950
LENMHSELEN VTRSKSLVDE QLYRLQFERA DLLKRIDEDQ GDLNDLMQKH
1960 1970 1980 1990 2000
KDLIAQSAAD IGQIQELQLQ LEETKKEKQK LREQLHMAQL RIQYLEQSTV
2010 2020 2030 2040 2050
ERAIVSRQEA IICDLENKTE FQKVQIKRFE VLVIRLRDSM IKMGEELSRA
2060 2070 2080 2090 2100
VKAEAQQREN SQYYQQRLEE LKAEMQELAQ REEEASRRCM ELEKYVEELA
2110 2120 2130 2140 2150
TVRQTLQTDL ETSIRRIADL QAALEEVVSS DSDTESVQTA VDCSSRSGKE
2160 2170 2180 2190 2200
GDNVSVISSQ PEGSLQSWMS CSLSLATDSV RIPSGQSVVS SSFHSPRVSE
2210 2220 2230 2240 2250
EAGDSERLRT ASSALSGAWD AARDASKAGS ASLHPVFPQK PYHLGDGEGF
2260 2270 2280 2290 2300
AVHRKSTLER SGPLSSSPPS QRTAVSPPSR DKLPSPSAAL SEFVEELRRK
2310 2320 2330 2340 2350
RAQRGQGSTL HLGDGPVLPI FQTTRASSLR RGRASSDEGD LSLKTRVKSP
2360 2370 2380 2390 2400
LGAEGIPGAT AGLSRSTSLK CISSEGPEDI TLLPDKQKTR FGSCESLLES
2410 2420 2430 2440 2450
GPCTRRKLSS PTGLLSPTLR PRRPCLESSV DDAISLELGK EPLVFQNRQF
2460 2470 2480 2490 2500
SHLMEETLDS DPFSWKLPSL NYRRQTKVDF DDFLPAIRKS DTPSSGAAKD
2510 2520 2530 2540 2550
GKEASKHPGV HFEMGEAADR SFLSGIKTIL KKSPEVKEDP AHLSDSSSSS
2560 2570 2580 2590 2600
SSIVSFKSTG GTGSGPRVPR LQGDGGERMS PEHRDPGSAR RDDDVESIMR

KYLQQ
Length:2,605
Mass (Da):288,883
Last modified:April 5, 2011 - v1
Checksum:i8846BDFDF32AC0E5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2L2S4R2L2_MOUSE
Myosin XVIIIb
Myo18b
75Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122466 Genomic DNA No translation available.
AC149590 Genomic DNA No translation available.
RefSeqiNP_083177.2, NM_028901.2
XP_006535325.1, XM_006535262.3
UniGeneiMm.441903

Genome annotation databases

EnsembliENSMUST00000086617; ENSMUSP00000083810; ENSMUSG00000072720
GeneIDi74376
KEGGimmu:74376
UCSCiuc008ytr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122466 Genomic DNA No translation available.
AC149590 Genomic DNA No translation available.
RefSeqiNP_083177.2, NM_028901.2
XP_006535325.1, XM_006535262.3
UniGeneiMm.441903

3D structure databases

SMRiE9PV66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PV66, 1 interactor
STRINGi10090.ENSMUSP00000083810

PTM databases

iPTMnetiE9PV66
PhosphoSitePlusiE9PV66

Proteomic databases

PaxDbiE9PV66
PRIDEiE9PV66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086617; ENSMUSP00000083810; ENSMUSG00000072720
GeneIDi74376
KEGGimmu:74376
UCSCiuc008ytr.2 mouse

Organism-specific databases

CTDi84700
MGIiMGI:1921626 Myo18b

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150860
InParanoidiE9PV66
KOiK10362
OMAiAPEDRWY
OrthoDBiEOG091G00GA
PhylomeDBiE9PV66
TreeFamiTF339614

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072720 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiE9PV66 baseline and differential
GenevisibleiE9PV66 MM

Family and domain databases

CDDicd01386 MYSc_Myo18, 1 hit
Gene3Di3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR028561 MYO18B
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR002928 Myosin_tail
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase
PANTHERiPTHR13140:SF372 PTHR13140:SF372, 1 hit
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PV66_MOUSE
AccessioniPrimary (citable) accession number: E9PV66
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again