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Protein

Diacylglycerol kinase

Gene

Dgkd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138334 Dgkd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PUQ8
PaxDbiE9PUQ8
PeptideAtlasiE9PUQ8
PRIDEiE9PUQ8

PTM databases

iPTMnetiE9PUQ8
PhosphoSitePlusiE9PUQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000070738 Expressed in 242 organ(s), highest expression level in thymus
ExpressionAtlasiE9PUQ8 baseline and differential
GenevisibleiE9PUQ8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027517

Structurei

3D structure databases

ProteinModelPortaliE9PUQ8
SMRiE9PUQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 146PHInterPro annotationAdd BLAST94
Domaini163 – 213Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini235 – 286Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini317 – 451DAGKcInterPro annotationAdd BLAST135
Domaini1151 – 1214SAMInterPro annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili617 – 637Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1170 Eukaryota
ENOG410XSJR LUCA
GeneTreeiENSGT00760000119050
InParanoidiE9PUQ8
KOiK00901
OMAiVVEMVNN
OrthoDBiEOG091G00SK
TreeFamiTF313104

Family and domain databases

CDDicd00029 C1, 2 hits
cd09575 SAM_DGK-delta, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR037606 DGK-delta_SAM
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00169 PH, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PUQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR
60 70 80 90 100
QKTILKEGML TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD
110 120 130 140 150
ASVAESSTKN VNNSFTVITP CRKLILCADN RKEMEDWIAA LKTVQNKEHF
160 170 180 190 200
EPTQYSMDHF SGMHNWYACS HARPTYCNVC REVLSGVTSH GLSCEVCKFK
210 220 230 240 250
AHKRCAVRAT SNCKWTTLAS IGKDIIEDED GIAMPHQWLE GNLPVSAKCI
260 270 280 290 300
VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLVMKCPLGL CKVSVIPPTA
310 320 330 340 350
LNSIDSDGFW KATCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ
360 370 380 390 400
VFDLMNGGPH LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ
410 420 430 440 450
LGVLPLGTGN DLARVLGWGS ACDDDTQLPQ ILAKLERAST KMLDRWSVMA
460 470 480 490 500
YETKLPRQAS SSTVTEDFSE DSEVQQILFY EDSVAAHLSK ILTSDQHSVV
510 520 530 540 550
ISSAKVLCET VKDFVARVGK AYEKTTESSQ ESEVMAKKCS VLKEKLDSLL
560 570 580 590 600
KTLDDESQAS SSLSNPPPTI AEEAEDGDGS GNICSSTGDH LVGSACPSRP
610 620 630 640 650
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QQGFVLGLSE
660 670 680 690 700
SEKKDLKTDN RVCTSSVHSE SCVIAKGRSQ RKASRAPCEK LVSKGLSLGS
710 720 730 740 750
SASLPPGTGS RDSLPALNTK ILYPSVRAGM SGSLPGGSVI SRLLINADPF
760 770 780 790 800
NAEPENLEYY TEKCVMNNYF GIGLDAKISL DFNNKRDEHP EKCRSRTKNM
810 820 830 840 850
MWYGVLGTKE LLHRTYRNLE QKVLLECDGR PIPLPSLQGI AVLNIPSYAG
860 870 880 890 900
GTNFWGGTKE DDTFAAPSFD DKILEVVAVF GSMQMAVSRV IKLQHHRIAQ
910 920 930 940 950
CRTVKISILG DEGVPVQVDG EAWIQPPGYI RIVHKNRAQT LTRDRAFENT
960 970 980 990 1000
LKSWEDKQKC ELSRPPSFSL HPEILSEEEA TQMDQFGQAA GGLIHSIREI
1010 1020 1030 1040 1050
AQSHRAMEQE LAHAVNASSK AMERVYGKPR TAEGLNCSFV LEMVNNIRAL
1060 1070 1080 1090 1100
RSETELLLAG KMALQLDPPQ KERLGAALIE MDQQLRKLTD TPWLCQPLEP
1110 1120 1130 1140 1150
GEEESLQQNV MLDLTKRSRS GKFRLVTKFK KEKNNKNKEV HSNLGGPVHL
1160 1170 1180 1190 1200
WGTEEVAAWL EHLSLCEYKD IFTRHDIRGS ELLHLERRDL KDLGVTKVGH
1210 1220
MKRILCGIKE LSRSSPAAEA
Length:1,220
Mass (Da):135,208
Last modified:April 5, 2011 - v1
Checksum:i1635F45B96741B7E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WP73A0A087WP73_MOUSE
Diacylglycerol kinase, delta
Dgkd
364Annotation score:
A0A087WQ75A0A087WQ75_MOUSE
Diacylglycerol kinase, delta
Dgkd
218Annotation score:
A0A087WP49A0A087WP49_MOUSE
Diacylglycerol kinase, delta
Dgkd
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102630 Genomic DNA No translation available.
AC162281 Genomic DNA No translation available.
RefSeqiNP_808314.2, NM_177646.3
UniGeneiMm.277217

Genome annotation databases

EnsembliENSMUST00000027517; ENSMUSP00000027517; ENSMUSG00000070738
GeneIDi227333
KEGGimmu:227333
UCSCiuc011wos.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102630 Genomic DNA No translation available.
AC162281 Genomic DNA No translation available.
RefSeqiNP_808314.2, NM_177646.3
UniGeneiMm.277217

3D structure databases

ProteinModelPortaliE9PUQ8
SMRiE9PUQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027517

PTM databases

iPTMnetiE9PUQ8
PhosphoSitePlusiE9PUQ8

Proteomic databases

MaxQBiE9PUQ8
PaxDbiE9PUQ8
PeptideAtlasiE9PUQ8
PRIDEiE9PUQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027517; ENSMUSP00000027517; ENSMUSG00000070738
GeneIDi227333
KEGGimmu:227333
UCSCiuc011wos.1 mouse

Organism-specific databases

CTDi8527
MGIiMGI:2138334 Dgkd

Phylogenomic databases

eggNOGiKOG1170 Eukaryota
ENOG410XSJR LUCA
GeneTreeiENSGT00760000119050
InParanoidiE9PUQ8
KOiK00901
OMAiVVEMVNN
OrthoDBiEOG091G00SK
TreeFamiTF313104

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070738 Expressed in 242 organ(s), highest expression level in thymus
ExpressionAtlasiE9PUQ8 baseline and differential
GenevisibleiE9PUQ8 MM

Family and domain databases

CDDicd00029 C1, 2 hits
cd09575 SAM_DGK-delta, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR037606 DGK-delta_SAM
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00169 PH, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PUQ8_MOUSE
AccessioniPrimary (citable) accession number: E9PUQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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