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Protein
Submitted name:

Neurexin-2

Gene

Nrxn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-2Imported
Gene namesi
Name:Nrxn2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1096362 Nrxn2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1629 – 1649HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324424329 – 1703Sequence analysisAdd BLAST1675

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9PUM9
PaxDbiE9PUM9
PRIDEiE9PUM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000033768 Expressed in 119 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9PUM9 baseline and differential
GenevisibleiE9PUM9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109089

Structurei

3D structure databases

ProteinModelPortaliE9PUM9
SMRiE9PUM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 206LAM_G_DOMAINInterPro annotationAdd BLAST179
Domaini202 – 242EGF-likeInterPro annotationAdd BLAST41
Domaini289 – 479LAM_G_DOMAINInterPro annotationAdd BLAST191
Domaini486 – 679LAM_G_DOMAINInterPro annotationAdd BLAST194
Domaini683 – 720EGF-likeInterPro annotationAdd BLAST38
Domaini725 – 897LAM_G_DOMAINInterPro annotationAdd BLAST173
Domaini911 – 1086LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini1089 – 1126EGF-likeInterPro annotationAdd BLAST38
Domaini1130 – 1338LAM_G_DOMAINInterPro annotationAdd BLAST209

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
KOiK07377
TreeFamiTF321302

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

E9PUM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSRWQPP PQLPPLLLLL ALAAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVTISVDGI
410 420 430 440 450
LTTTGYTQED YTMLGSDDFF YIGGSPNTAD LPGSPVSNNF MGCLKDVVYK
460 470 480 490 500
NNDFKLELSR LAKEGDPKMK LQGDLSFRCE DVAALDPVTF ESPEAFVALP
510 520 530 540 550
RWSAKRTGSI SLDFRTTEPN GLLLFSQGRR AGAGVGSHSS TQRADYFAME
560 570 580 590 600
LLDGYLYLLL DMGSGGIKLR ASSRKVNDGE WCHVDFQRDG RKGSISVNSR
610 620 630 640 650
STPFLATGES EVLDLESELY LGGLPEGGRV DLPLPPEVWT AALRAGYVGC
660 670 680 690 700
VRDLFIDGRS RDLRGLAEAQ GAVGVAPFCS RETLKQCASA PCRNGGICRE
710 720 730 740 750
GWNRFVCDCI GTGFLGRVCE REATVLSYDG SMYMKIMLPT AMHTEAEDVS
760 770 780 790 800
LRFMSQRAYG LMMATTSRES ADTLRLELDG GQMRLTVNLD CLRVGCAPSK
810 820 830 840 850
GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ MAGAHTRLEF
860 870 880 890 900
HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK DGDITYCELN
910 920 930 940 950
ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF
960 970 980 990 1000
NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS
1010 1020 1030 1040 1050
RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN MFSNLPKLVA
1060 1070 1080 1090 1100
SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS TTCTEESCAN
1110 1120 1130 1140 1150
QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL ITYTWPPNDR
1160 1170 1180 1190 1200
PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ GTVGVIFNVG
1210 1220 1230 1240 1250
TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN
1260 1270 1280 1290 1300
ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ
1310 1320 1330 1340 1350
GQVSGLYYNG LKVLALAAES DPNVRTEGHL RLVGEGPSVL LSAETTATTL
1360 1370 1380 1390 1400
LADMATTIME TTTTMATTTT RRGRSPTMRD STTQNTDDLL VASAECPSDD
1410 1420 1430 1440 1450
EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP TFYPFLTGVG
1460 1470 1480 1490 1500
ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS GEVFDSSLPP
1510 1520 1530 1540 1550
TDDEDFYTTF PLVTDRTTLL SPRKPRPNLR TDGATGAPGV LFAPSAPAPN
1560 1570 1580 1590 1600
LPAGKMNHRD PLQPLLENPP LGPGVPTAFE PRRPPPLRPG VTSAPGFPRL
1610 1620 1630 1640 1650
PTANPTGPGE RGPPGAVEVI RESSSTTGMV VGIVAAAALC ILILLYAMYK
1660 1670 1680 1690 1700
YRNRDEGSYQ VDQSRNYISN SAQSNGAVVK EKAPAAPKTP SKAKKNKDKE

YYV
Length:1,703
Mass (Da):184,017
Last modified:April 5, 2011 - v1
Checksum:i93C7606580D4518F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q7X7NRX2A_MOUSE
Neurexin-2
Nrxn2
1,710Annotation score:
E9Q5N7E9Q5N7_MOUSE
Neurexin-2
Nrxn2
1,503Annotation score:
E9PUN2E9PUN2_MOUSE
Neurexin-2
Nrxn2
660Annotation score:
E9PUN0E9PUN0_MOUSE
Neurexin-2
Nrxn2
1,640Annotation score:
E9PUN1E9PUN1_MOUSE
Neurexin-2
Nrxn2
353Annotation score:
F6WN33F6WN33_MOUSE
Neurexin-2
Nrxn2
206Annotation score:
F6Y027F6Y027_MOUSE
Neurexin-2
Nrxn2
216Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124394 Genomic DNA No translation available.
AC167245 Genomic DNA No translation available.
RefSeqiNP_001192163.1, NM_001205234.1
UniGeneiMm.329616
Mm.414022

Genome annotation databases

EnsembliENSMUST00000113462; ENSMUSP00000109089; ENSMUSG00000033768
GeneIDi18190
KEGGimmu:18190
UCSCiuc008giu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124394 Genomic DNA No translation available.
AC167245 Genomic DNA No translation available.
RefSeqiNP_001192163.1, NM_001205234.1
UniGeneiMm.329616
Mm.414022

3D structure databases

ProteinModelPortaliE9PUM9
SMRiE9PUM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109089

Proteomic databases

MaxQBiE9PUM9
PaxDbiE9PUM9
PRIDEiE9PUM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113462; ENSMUSP00000109089; ENSMUSG00000033768
GeneIDi18190
KEGGimmu:18190
UCSCiuc008giu.2 mouse

Organism-specific databases

CTDi9379
MGIiMGI:1096362 Nrxn2

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
KOiK07377
TreeFamiTF321302

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNrxn2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033768 Expressed in 119 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9PUM9 baseline and differential
GenevisibleiE9PUM9 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PUM9_MOUSE
AccessioniPrimary (citable) accession number: E9PUM9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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