UniProtKB - E9PUD2 (E9PUD2_MOUSE)
Protein
Dynamin-1-like protein
Gene
Dnm1l
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:3.6.5.5ARBA annotation
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- endocytosis Source: UniProtKB-KW
- mitochondrial fission Source: InterPro
- peroxisome fission Source: InterPro
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseARBA annotation |
Biological process | Biological rhythmsARBA annotation, EndocytosisARBA annotation |
Ligand | GTP-bindingUniRule annotationARBA annotation, Lipid-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Dnm1lImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921256, Dnm1l |
Subcellular locationi
Peroxisome
- Peroxisome ARBA annotation
Mitochondrion
- Mitochondrion outer membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Golgi apparatus
- Golgi apparatus ARBA annotation
Cytosol
- cytosol ARBA annotation
Other locations
- synaptic vesicle membrane ARBA annotation
- Endomembrane system ARBA annotation; Peripheral membrane protein ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Peroxisome
- peroxisome Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-KW
Other locations
- synaptic vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, Golgi apparatusARBA annotation, Membrane, Mitochondrion, Mitochondrion outer membraneARBA annotation, PeroxisomeARBA annotation, SynapseARBA annotationPTM / Processingi
Proteomic databases
jPOSTi | E9PUD2 |
MaxQBi | E9PUD2 |
PaxDbi | E9PUD2 |
PeptideAtlasi | E9PUD2 |
PRIDEi | E9PUD2 |
PTM databases
iPTMneti | E9PUD2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022789, Expressed in brainstem and 305 other tissues |
ExpressionAtlasi | E9PUD2, baseline and differential |
Genevisiblei | E9PUD2, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 315 | Dynamin-type GInterPro annotationAdd BLAST | 294 | |
Domaini | 620 – 711 | GEDInterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 536 – 566 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 110 – 130 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155504 |
OMAi | KTRVNIM |
OrthoDBi | 264244at2759 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030556, DNM1L IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf |
PANTHERi | PTHR11566, PTHR11566, 2 hits PTHR11566:SF39, PTHR11566:SF39, 2 hits |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9PUD2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL
60 70 80 90 100
LPRGTGVVTR RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA
110 120 130 140 150
EEWGKFLHTK NKLYTDFDEI RQEIENETER ISGNNKGVSP EPIHLKVFSP
160 170 180 190 200
NVVNLTLVDL PGMTKVPVGD QPKDIELQIR ELILRFISNP NSIILAVTAA
210 220 230 240 250
NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM DVLMGRVIPV
260 270 280 290 300
KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR
310 320 330 340 350
TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI
360 370 380 390 400
TKFATEYCNT IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL
410 420 430 440 450
NTIDILTAIR NATGPRPALF VPEVSFELLV KRQIKRLEEP SLRCVELVHE
460 470 480 490 500
EMQRIIQHCS NYSTQELLRF PKLHDAIVEV VTCLLRKRLP VTNEMVHNLV
510 520 530 540 550
AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA GSRDKVPSAG
560 570 580 590 600
GGIGDGGQEP TTGNWRGMLK TSKAEELLAE EKSKPIPIMP ASPQKGHAVN
610 620 630 640 650
LLDVPVPVAR KLSAREQRDC EVIERLIKSY FLIVRKNIQD SVPKAVMHFL
660 670 680 690 700
VNHVKDTLQS ELVGQLYKSS LLDDLLTESE DMAQRRKEAA DMLKALQGAS
710
QIIAEIRETH LW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8K1M6 | DNM1L_MOUSE | Dynamin-1-like protein | Dnm1l Drp1 | 742 | Annotation score: | ||
A0A2U3TZ67 | A0A2U3TZ67_MOUSE | Dynamin-1-like protein | Dnm1l | 587 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112943 Genomic DNA No translation available. |
RefSeqi | NP_690029.2, NM_152816.3 |
Genome annotation databases
Ensembli | ENSMUST00000096229; ENSMUSP00000093945; ENSMUSG00000022789 |
GeneIDi | 74006 |
UCSCi | uc007yil.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112943 Genomic DNA No translation available. |
RefSeqi | NP_690029.2, NM_152816.3 |
3D structure databases
SMRi | E9PUD2 |
ModBasei | Search... |
PTM databases
iPTMneti | E9PUD2 |
Proteomic databases
jPOSTi | E9PUD2 |
MaxQBi | E9PUD2 |
PaxDbi | E9PUD2 |
PeptideAtlasi | E9PUD2 |
PRIDEi | E9PUD2 |
Protocols and materials databases
Antibodypediai | 4096, 663 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000096229; ENSMUSP00000093945; ENSMUSG00000022789 |
GeneIDi | 74006 |
UCSCi | uc007yil.2, mouse |
Organism-specific databases
CTDi | 10059 |
MGIi | MGI:1921256, Dnm1l |
Phylogenomic databases
GeneTreei | ENSGT00940000155504 |
OMAi | KTRVNIM |
OrthoDBi | 264244at2759 |
Miscellaneous databases
BioGRID-ORCSi | 74006, 8 hits in 19 CRISPR screens |
ChiTaRSi | Dnm1l, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022789, Expressed in brainstem and 305 other tissues |
ExpressionAtlasi | E9PUD2, baseline and differential |
Genevisiblei | E9PUD2, MM |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030556, DNM1L IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf |
PANTHERi | PTHR11566, PTHR11566, 2 hits PTHR11566:SF39, PTHR11566:SF39, 2 hits |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PUD2_MOUSE | |
Accessioni | E9PUD2Primary (citable) accession number: E9PUD2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |