Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 68 (16 Oct 2019)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

A-kinase anchor protein SPHKAP

Gene

Sphkap

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A-kinase anchor protein SPHKAPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SphkapImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924879 Sphkap

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PUC4

PeptideAtlas

More...
PeptideAtlasi
E9PUC4

PRoteomics IDEntifications database

More...
PRIDEi
E9PUC4

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9PUC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026163 Expressed in 156 organ(s), highest expression level in visual cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PUC4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PUC4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PUC4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1565 – 1638AKAP_110InterPro annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni272 – 293DisorderedSequence analysisAdd BLAST22
Regioni964 – 989DisorderedSequence analysisAdd BLAST26
Regioni1363 – 1406DisorderedSequence analysisAdd BLAST44
Regioni1421 – 1520DisorderedSequence analysisAdd BLAST100
Regioni1540 – 1559DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi272 – 289PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1458 – 1474PolarSequence analysisAdd BLAST17
Compositional biasi1475 – 1497PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1498 – 1520PolarSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHCW Eukaryota
ENOG41113DA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153313

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYRYMLK

Database of Orthologous Groups

More...
OrthoDBi
33853at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105426

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018292 AKAP_110_C
IPR008382 SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226 PTHR10226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05716 AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9PUC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVNSRLSVQ SNVESPLMHE GSEPQQITSS AAGNLAGSIT ACKKVLRSNS
60 70 80 90 100
LLESTDYWLQ NQRTPCQIGF VEDESENCAS VCFVNLDVNK DACITENLQQ
110 120 130 140 150
KLVNVSPDLP NLISSMNVQQ PKENEIVLLS GLASGNLQAD FDVSQCPWLP
160 170 180 190 200
DICLVQCARG NRPNSTNCII FEINKFLIGL EVVQERQLHL ETNVLKLEDD
210 220 230 240 250
TNCSLSSIEE DFLTASEHLE EEIEVDDCRS GLENTNVSAN VLESKKPKET
260 270 280 290 300
TQEGWDYHKE KLHCALGEKH IRKHRTPSTK TEGSKENTEE NTSLKSLNRL
310 320 330 340 350
VRPSHLKSEV AGNKQLATNY SYPENIKGEL ETSQMLFIPR DAYLSMVKKD
360 370 380 390 400
VLSPCSVLSE QGGSHRDHDV TPNPLPPVQN GEASTGEYAT NLAESVMQDA
410 420 430 440 450
FIRLSQSQPT LPQESAVSFS MRSALLPSGC CTKDMVVPRS WNELPKIVIV
460 470 480 490 500
QSPDGSDTVP EPNVSSWPDM EFVETSGIFS ADSSSRPTQS ALEVALACAA
510 520 530 540 550
TVIGTISSPQ ATERFAMEQE SLVSTYAQRG TGVQQTQVPQ AFMAPSTTEY
560 570 580 590 600
SFPSALCGMT QVASAVAVCG LCEKEEATCP VAPTDLLPTS GASEEISSIG
610 620 630 640 650
SLVMERSTEL GKEAIAEALL REATLILARP DAYSSLGELL ESVNQRIIET
660 670 680 690 700
TSKTQTLCTE SVQRNELAHT LSNVILKHSV DELHQKTTMA HPTDERHPCG
710 720 730 740 750
TLDTLMESVN QLLHNVICFT FKKMNHIVTL SEHPSFDQAA GQAWVKAFAC
760 770 780 790 800
PSSQPLSNAH GTGLVIRNLV EDASPKSNKG GARPELVNNP RLQSEFSCSH
810 820 830 840 850
RMFDSTAKSF PKEIYLKGIM GEDTRNPHHT LNYDSNERRA STDLGKLTTA
860 870 880 890 900
SEGCSGFQET EDSIVPNTQE KYICATPLNN EAQVNLSLLG DDLSVPAQST
910 920 930 940 950
LEAKQSEVYG ITDFAEELAE TVVSMATEIA AICLDNSNGK QPWFCAWKRG
960 970 980 990 1000
NEFLTAPNGS CRSLKRKKEN SSAGSTVRKH KPPRLSEIKR KADEHPELKE
1010 1020 1030 1040 1050
KLMNRVMDES MNLEDIPDSV STFANEVAAK IMNLTEFSMV DGVWQGQSCS
1060 1070 1080 1090 1100
RTRLLGGDRW NRLKASSCES IPEEDSEARV FVNSLGLMST LSQPVSRASS
1110 1120 1130 1140 1150
VSKQSSCESI TDEFSRFMVK QMENEGRGFE LLLDYYAGKN ASSIMSSAMQ
1160 1170 1180 1190 1200
QACQKNDHLN VRPSCPSKQS STESITEEFY RYMLRDIAKE SKDGASSRRS
1210 1220 1230 1240 1250
SHDWTTGLLS PSTRSPLCYR QSSMPDSRSP CSRLTVNAPV KANSLDGFAQ
1260 1270 1280 1290 1300
NCPQDSVNVQ PVSRASSSGL CKSDSCLYRR SGTDQITNML IHETWASSIE
1310 1320 1330 1340 1350
ALMRKNKIIA DDSEAANASP GPVSSGSPLQ VEKNANRLAT SKGHRGPTLL
1360 1370 1380 1390 1400
VQESVDYQRK DAVTEGNHSP VSSPGKTAPV KKPSDFDPRR ETSACHNAAG
1410 1420 1430 1440 1450
LNSPRRSLCS RDVPLIQIET DQKEECIGEP GPFLSQSGSL EETEGHQPEE
1460 1470 1480 1490 1500
TIPDVARNED TAPSTCQSSR DSLETSGEVE VEVLKEDIPR DESRNPPSSS
1510 1520 1530 1540 1550
EESTGSWSQL ANEEDIPDDT SSFLQLSERS MSELVEEKEI LKEQSESIKE
1560 1570 1580 1590 1600
HASGLPGRAA SPQRSLLVIN FDLEPECPDA ELRATLQWIA ASELGIPTIY
1610 1620 1630 1640 1650
FKKSQESRIE KFLDVVKLVQ QKSWKVGDIF HAVVQYCKLH AEQKERTPSL

FDWLLELG
Length:1,658
Mass (Da):182,090
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FD8F62B876E31BA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6NSW3SPKAP_MOUSE
A-kinase anchor protein SPHKAP
Sphkap Kiaa1678
1,687Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1Y6A0A0R4J1Y6_MOUSE
A-kinase anchor protein SPHKAP
Sphkap
1,400Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC138359 Genomic DNA No translation available.
AC154144 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_766018.3, NM_172430.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000160953; ENSMUSP00000124872; ENSMUSG00000026163

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77629

UCSC genome browser

More...
UCSCi
uc007bsq.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138359 Genomic DNA No translation available.
AC154144 Genomic DNA No translation available.
RefSeqiNP_766018.3, NM_172430.3

3D structure databases

SMRiE9PUC4
ModBaseiSearch...

PTM databases

SwissPalmiE9PUC4

Proteomic databases

MaxQBiE9PUC4
PeptideAtlasiE9PUC4
PRIDEiE9PUC4

Genome annotation databases

EnsembliENSMUST00000160953; ENSMUSP00000124872; ENSMUSG00000026163
GeneIDi77629
UCSCiuc007bsq.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80309
MGIiMGI:1924879 Sphkap

Phylogenomic databases

eggNOGiENOG410IHCW Eukaryota
ENOG41113DA LUCA
GeneTreeiENSGT00940000153313
OMAiFYRYMLK
OrthoDBi33853at2759
TreeFamiTF105426

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sphkap mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026163 Expressed in 156 organ(s), highest expression level in visual cortex
ExpressionAtlasiE9PUC4 baseline and differential
GenevisibleiE9PUC4 MM

Family and domain databases

InterProiView protein in InterPro
IPR018292 AKAP_110_C
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PUC4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PUC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again