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Entry version 74 (16 Oct 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

IQ motif and SEC7 domain-containing protein 1

Gene

Iqsec1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IQ motif and SEC7 domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Iqsec1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1196356 Iqsec1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9PUA3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9PUA3

PeptideAtlas

More...
PeptideAtlasi
E9PUA3

PRoteomics IDEntifications database

More...
PRIDEi
E9PUA3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9PUA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034312 Expressed in 266 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PUA3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9PUA3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PUA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini501 – 694SEC7InterPro annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni249 – 277DisorderedSequence analysisAdd BLAST29
Regioni296 – 318DisorderedSequence analysisAdd BLAST23
Regioni333 – 501DisorderedSequence analysisAdd BLAST169
Regioni861 – 889DisorderedSequence analysisAdd BLAST29
Regioni901 – 1099DisorderedSequence analysisAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 33PolarSequence analysisAdd BLAST20
Compositional biasi252 – 277PolyampholyteSequence analysisAdd BLAST26
Compositional biasi304 – 318PolarSequence analysisAdd BLAST15
Compositional biasi374 – 388PolyampholyteSequence analysisAdd BLAST15
Compositional biasi410 – 427PolyampholyteSequence analysisAdd BLAST18
Compositional biasi452 – 482PolarSequence analysisAdd BLAST31
Compositional biasi868 – 889PolarSequence analysisAdd BLAST22
Compositional biasi924 – 943PolarSequence analysisAdd BLAST20
Compositional biasi978 – 999Pro-richSequence analysisAdd BLAST22
Compositional biasi1020 – 1043BasicSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0931 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156915

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQSECSD

Database of Orthologous Groups

More...
OrthoDBi
837077at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13318 PH_IQSEC, 1 hit
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR030737 IQSEC1
IPR033742 IQSEC_PH
IPR011993 PH-like_dom_sf
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10663:SF327 PTHR10663:SF327, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16453 IQ_SEC7_PH, 1 hit
PF01369 Sec7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PUA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACRRRYFVE GEAPSSETGT SLDSPSAYHQ GPLVPGSSLS PDHYEHTSVG
60 70 80 90 100
AYGLYAGPGP QQRTRRPRLQ HSTSVLRKQA EEEAIKRSRS LSESYELSSD
110 120 130 140 150
LQDKQVEMLE RKYGGRLVTR HAARTIQTAF RQYQMNKNFE RLRSSMSENR
160 170 180 190 200
MSRRIVLSNM RMQFSFEGPE KVHSSYFEGK QVSVTNDGSQ LGALVPSECG
210 220 230 240 250
DLSDPALKSP APSSDFADAI TELEDAFSRQ VKSLAESIDD ALNCRSLHSE
260 270 280 290 300
EVPASDTARA RDTEPKPGLH GMDHRKLDEM TASYSDVTLY IDEEELSPPL
310 320 330 340 350
PLSQAGDRPS STESDLRLRS GGAAQDYWAL AHKEDKADTD TSCRSTPSLE
360 370 380 390 400
RPEPRLRVEH LPLLTIEPPS DSSVELSDRS DRSSLKRQSA YERSLGGQQG
410 420 430 440 450
SPKHGPHGGP PKGLPREEPE LRPRPPRPLE SHLAINGSAN RQSKSESDYS
460 470 480 490 500
DGDNDSINST SNSNDTINCS SESSSRDSLR EQTLSKQTYH KETRNSWDSP
510 520 530 540 550
AFSNDVIRKR HYRIGLNLFN KKPEKGIQYL IERGFVPDTP VGVAHFLLQR
560 570 580 590 600
KGLSRQMIGE FLGNRQKQFN RDVLDCVVDE MDFSAMELDE ALRKFQAHIR
610 620 630 640 650
VQGEAQKVER LIEAFSQRYC VCNPGVVRQF RNPDTIFILA FAIILLNTDM
660 670 680 690 700
YSPNVKPERK MKLEDFVKNL RGVDDGEDIP RETLIGIYER IRKRELKTNE
710 720 730 740 750
DHVSQVQKVE KLIVGKKPIG SLHHGLGCVL SLPHRRLVCY CRLFEVPDPN
760 770 780 790 800
KPQKLGLHQR EIFLFNDLLV VTKIFQKKKN SVTYSFRQSF SLYGMQVLLF
810 820 830 840 850
ENQYYPNGIR LTSAVPGADI KVLINFNAPN PQDRKKFTDD LRESVAEVQE
860 870 880 890 900
MEKHRIESEL EKQKGVVRPS MSQCSSLKKE SGNGTLSRAC LDDSYASGEG
910 920 930 940 950
LKRSALSSSL RDLSEAGKRG RRSSAGSLES NVEGSIISSP HMRRRATSTR
960 970 980 990 1000
ECPSRPPQPV PNSSSLLGSL FGSRRGKPPP QAHPPSAPPP APPHAHHPGP
1010 1020 1030 1040 1050
SEGPLHGHHA QYCHAQQNPP PYHHHHHYHP PPHLQHTHQY HHGPHGGHPP
1060 1070 1080 1090
YGAHAHSHPP LPTAHPGHAG HSAHHHGQPP APPPPTSSKA KPSGISTVV
Length:1,099
Mass (Da):122,655
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF97F59FBE097A0D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R0S2IQEC1_MOUSE
IQ motif and SEC7 domain-containing...
Iqsec1 Kiaa0763
961Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM83A0A1D5RM83_MOUSE
IQ motif and SEC7 domain-containing...
Iqsec1
1,051Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1U6A0A0R4J1U6_MOUSE
IQ motif and SEC7 domain-containing...
Iqsec1
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC121954 Genomic DNA No translation available.
AC165974 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001127856.1, NM_001134384.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000101151; ENSMUSP00000098710; ENSMUSG00000034312

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
232227

UCSC genome browser

More...
UCSCi
uc012epa.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121954 Genomic DNA No translation available.
AC165974 Genomic DNA No translation available.
RefSeqiNP_001127856.1, NM_001134384.1

3D structure databases

SMRiE9PUA3
ModBaseiSearch...

PTM databases

iPTMnetiE9PUA3

Proteomic databases

EPDiE9PUA3
MaxQBiE9PUA3
PeptideAtlasiE9PUA3
PRIDEiE9PUA3

Genome annotation databases

EnsembliENSMUST00000101151; ENSMUSP00000098710; ENSMUSG00000034312
GeneIDi232227
UCSCiuc012epa.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9922
MGIiMGI:1196356 Iqsec1

Phylogenomic databases

eggNOGiKOG0931 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000156915
OMAiVQSECSD
OrthoDBi837077at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Iqsec1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034312 Expressed in 266 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9PUA3 baseline and differential
GenevisibleiE9PUA3 MM

Family and domain databases

CDDicd13318 PH_IQSEC, 1 hit
cd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR030737 IQSEC1
IPR033742 IQSEC_PH
IPR011993 PH-like_dom_sf
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PANTHERiPTHR10663:SF327 PTHR10663:SF327, 1 hit
PfamiView protein in Pfam
PF16453 IQ_SEC7_PH, 1 hit
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PUA3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PUA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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