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UniProtKB - E9PTS6 (E9PTS6_RAT)
Protein
Submitted name:
Kruppel-like factor 11
Gene
Klf11
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- cellular response to peptide Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of apoptotic process Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Kruppel-like factor 11Imported |
Gene namesi | Name:Klf11Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306646, Klf11 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear body Source: Ensembl
Other locations
- focal adhesion Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000054259, Expressed in lung and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 383 – 412 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 413 – 442 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 443 – 470 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 195 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 147 – 161 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 174 – 189 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
OMAi | ARRHMTA |
PhylomeDBi | E9PTS6 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
E9PTS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSPGSTGPG DARAADIMDI CESILERKRH DSERSTCSIL EQTDIEAVEA
60 70 80 90 100
LVCMSSWGQR SQVRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI
110 120 130 140 150
TPPQSPELME PTGTPVPSQV INSQGCMATA LPPSPTGGPR TLSKGEPPEP
160 170 180 190 200
SSESSCRAVM TSVIRHTGES PAPTCFPTGP TQEQPASDSR GGQDPLLDHL
210 220 230 240 250
EALQDTRLAD GLLVTNLVSC QPCLHKSGGL FPIDKGQQTV WPTAVQTCLP
260 270 280 290 300
KNPESDLSRK TTPFISVPVS SPPVLCQMIP VAGQNGMLSA FLRPPTQLPA
310 320 330 340 350
GTIKPILPQA ASMSQPVFMG PPVPQGTVML VLPQSTFPQP AACPSSVMAI
360 370 380 390 400
GNTKLLPLAP APVFVASSQN CAPQVDFSRR RNYVCNFPGC RKTYFKSSHL
410 420 430 440 450
KAHLRTHTGE KPFTCSWDGC DKKFARSDEL SRHRRTHTGE KKFVCPVCDR
460 470 480 490 500
RFMRSDHLTK HARRHMTTKK IPGWQAEVGK LNRITLAESP RSILEPLPAS
G
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07063722 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSRNOT00000086548; ENSRNOP00000075389; ENSRNOG00000054259 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07063722 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PTS6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000231 |
Proteomic databases
PaxDbi | E9PTS6 |
Genome annotation databases
Ensembli | ENSRNOT00000086548; ENSRNOP00000075389; ENSRNOG00000054259 |
Organism-specific databases
RGDi | 1306646, Klf11 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
OMAi | ARRHMTA |
PhylomeDBi | E9PTS6 |
Gene expression databases
Bgeei | ENSRNOG00000054259, Expressed in lung and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PTS6_RAT | |
Accessioni | E9PTS6Primary (citable) accession number: E9PTS6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | September 29, 2021 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |