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Entry version 75 (22 Apr 2020)
Sequence version 3 (22 Jul 2015)
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Protein

Transient receptor potential cation channel subfamily M member 2

Gene

Trpm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels (PubMed:16651700, PubMed:16260005, PubMed:11804595, PubMed:16601673, PubMed:19454650). Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca2+ binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity (By similarity). Also contributes to Ca2+ release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca2+ levels (Probable). Besides, mediates the release of lysosomal Zn2+ stores in response to reactive oxygen species, leading to increased cytosolic Zn2+ levels (PubMed:25562606). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD+) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:16260005, PubMed:16601673, PubMed:25562606). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (By similarity). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca2+ levels (PubMed:16601673). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca2+ levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca2+ and Zn2+ levels (By similarity). Confers susceptibility to cell death following oxidative stress (PubMed:16651700, PubMed:11804595, PubMed:19454650, PubMed:25562606).By similarityCurated6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi841CalciumBy similarity1
Metal bindingi844CalciumBy similarity1
Metal bindingi867CalciumBy similarity1
Metal bindingi1071CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Sodium channel
Biological processCalcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3295583 TRP channels
R-RNO-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
1311889 Trpm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 751CytoplasmicCuratedAdd BLAST751
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei752 – 768By similarityAdd BLAST17
Topological domaini769 – 793CytoplasmicCuratedAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei794 – 814HelicalBy similarityAdd BLAST21
Topological domaini815 – 825ExtracellularCuratedAdd BLAST11
Transmembranei826 – 846HelicalBy similarityAdd BLAST21
Topological domaini847 – 865CytoplasmicCuratedAdd BLAST19
Transmembranei866 – 886HelicalBy similarityAdd BLAST21
Topological domaini887 – 894ExtracellularCurated8
Transmembranei895 – 915HelicalBy similarityAdd BLAST21
Topological domaini916 – 927CytoplasmicCuratedAdd BLAST12
Transmembranei928 – 948HelicalBy similarityAdd BLAST21
Topological domaini949 – 968ExtracellularCuratedAdd BLAST20
Intramembranei969 – 983Pore-formingBy similarityAdd BLAST15
Topological domaini984 – 1020ExtracellularCuratedAdd BLAST37
Transmembranei1021 – 1042HelicalBy similarityAdd BLAST22
Topological domaini1043 – 1077CytoplasmicCuratedAdd BLAST35
Intramembranei1078 – 1096By similarityAdd BLAST19
Topological domaini1097 – 1507CytoplasmicCuratedAdd BLAST411

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004381921 – 1507Transient receptor potential cation channel subfamily M member 2Add BLAST1507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi994 ↔ 1006By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PTA2

PeptideAtlas

More...
PeptideAtlasi
E9PTA2

PRoteomics IDEntifications database

More...
PRIDEi
E9PTA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in pancreas beta-cells (PubMed:16601673). Detected in fetal brain cortex neurons (at protein level) (PubMed:16651700).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001216 Expressed in spleen and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001631

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1351 – 1502Nudix hydrolasePROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1387 – 1408Nudix boxPROSITE-ProRule annotationAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
KOG4195 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001390_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PTA2

KEGG Orthology (KO)

More...
KOi
K04977

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEMYLKE

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PTA2

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR029594 TRPM2
IPR041491 TRPM_SLOG

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF2 PTHR13800:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55811 SSF55811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51462 NUDIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9PTA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLDQRRTD SDQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRLLCSF
60 70 80 90 100
SSEKQENLSS WIPENIKKKE CVYFVESSKL SDAGKVVCEC GYTHEQHIEV
110 120 130 140 150
AIKPHTFQGK EWDPKKHVHE MPTDAFGDIV FTGLSQKVGK YVRLSQDTSS
160 170 180 190 200
IVIYQLMTQH WGLDVPSLLI SVTGGAKNFN MKLRLKSIFR RGLVKVAQTT
210 220 230 240 250
GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGDVITIGI ATWGTIHNRE
260 270 280 290 300
ALIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL
310 320 330 340 350
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAITNGTPCV
360 370 380 390 400
IVEGSGRVAD VIAQVAALPV SEITISLIQQ KLSVFFQEMF ETFTENQIVE
410 420 430 440 450
WTKKIQDIVR RRQLLTVFRE GKDGQQDVDV AILQALLKAS RSQDHFGHEN
460 470 480 490 500
WDHQLKLAVA WNRVDIARSE IFTDEWQWKP SDLHPMMTAA LISNKPEFVR
510 520 530 540 550
LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA EEHERLAYAS
560 570 580 590 600
ETPRLQMHHV AQVLRELLGD STQLLYPRPR YTDRPRLSLP MPHIKLNVQG
610 620 630 640 650
VSLRSLYKRS TGHVTFTIDP VRDLLIWAII QNHRELAGII WAQSQDCTAA
660 670 680 690 700
ALACSKILKE LSKEEEDTDS SEEMLALADE FEHRAIGVFT ECYRKDEERA
710 720 730 740 750
QKLLVRVSEA WGKTTCLQLA LEAKDMKFVS HGGIQAFLTK VWWGQLCVDN
760 770 780 790 800
GLWRIILCML AFPLLFTGFI SFREKRLQAL CRLARVRAFF NAPVVIFYLN
810 820 830 840 850
ILSYFAFLCL FAYVLMVDFQ PSPSWCEYLI YLWLFSLVCE ETRQLFYDPD
860 870 880 890 900
GCGLMKMASL YFSDFWNKLD VGAILLFIAG LTCRLIPATL YPGRIILSLD
910 920 930 940 950
FIMFCLRLMH IFTISKTLGP KIIIVKRMMK DVFFFLFLLA VWVVSFGVAK
960 970 980 990 1000
QAILIHNESR VDWIFRGVIY HSYLTIFGQI PTYIDGVNFS MDQCSPNGTD
1010 1020 1030 1040 1050
PYKPKCPESD WTGQAPAFPE WLTVTLLCLY LLFANILLLN LLIAMFNYTF
1060 1070 1080 1090 1100
QEVQEHTDQI WKFQRHDLIE EYHGRPPAPP PLILLSHLQL LIKRIVLKIP
1110 1120 1130 1140 1150
AKRHKQLKNK LEKNEEAALL SWELYLKENY LQNQQYQHKQ RPEQKIQDIS
1160 1170 1180 1190 1200
EKVDTMVDLL DMDRVKRSGS TEQRLASLEE QVTQMGRSLH WIVTTLKDSG
1210 1220 1230 1240 1250
FGSGAGALTL AQRAFDEPDA ELSIRKKGEE GGDGYHVSAR HLLYPDARIM
1260 1270 1280 1290 1300
RFPVPNEKVP WEAEFLIYDP PFYTAEKKDA TLTDPVGDTA EPLSKINYNV
1310 1320 1330 1340 1350
VDGLMDRCSF HGTYVVQYGF PLNPMGRTGL RGRGSLSWFG PNHTLQPVVT
1360 1370 1380 1390 1400
RWKRNQGGGI CRKSVRKMLE VLVVKLPQSE HWALPGGSRE PGKMLPRKLK
1410 1420 1430 1440 1450
QVLQQEYWVT FETLLRQGTE VYKGYVDDPR NTDNAWIETV AVSIHFQDQN
1460 1470 1480 1490 1500
DVELKRLEEN LQTHDPKESA RGLEMSTEWQ VVDRRIPLYV NHKKILQKVA

SLFGAHF
Length:1,507
Mass (Da):172,259
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E54E154A0166F99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti783L → P in AAW65801 (PubMed:16260005).Curated1
Sequence conflicti783L → P in BAE72117 (PubMed:16651700).Curated1
Sequence conflicti1210L → LA in AAW65801 (PubMed:16260005).Curated1
Sequence conflicti1374V → M in AAW65801 (PubMed:16260005).Curated1
Sequence conflicti1374V → M in BAE72117 (PubMed:16651700).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB193179 mRNA Translation: BAE72117.1
AY749166 mRNA Translation: AAW65801.1
AABR07044580 Genomic DNA No translation available.
AABR07044581 Genomic DNA No translation available.
AABR07072820 Genomic DNA No translation available.
AC109383 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001011559.1, NM_001011559.1
XP_006256311.1, XM_006256249.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000001631; ENSRNOP00000001631; ENSRNOG00000001216

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
294329

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:294329

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193179 mRNA Translation: BAE72117.1
AY749166 mRNA Translation: AAW65801.1
AABR07044580 Genomic DNA No translation available.
AABR07044581 Genomic DNA No translation available.
AABR07072820 Genomic DNA No translation available.
AC109383 Genomic DNA No translation available.
RefSeqiNP_001011559.1, NM_001011559.1
XP_006256311.1, XM_006256249.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001631

Proteomic databases

PaxDbiE9PTA2
PeptideAtlasiE9PTA2
PRIDEiE9PTA2

Genome annotation databases

EnsembliENSRNOT00000001631; ENSRNOP00000001631; ENSRNOG00000001216
GeneIDi294329
KEGGirno:294329

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7226
RGDi1311889 Trpm2

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
KOG4195 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000156404
HOGENOMiCLU_001390_0_2_1
InParanoidiE9PTA2
KOiK04977
OMAiWEMYLKE
OrthoDBi738147at2759
PhylomeDBiE9PTA2
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-RNO-3295583 TRP channels
R-RNO-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9PTA2

Gene expression databases

BgeeiENSRNOG00000001216 Expressed in spleen and 7 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR029594 TRPM2
IPR041491 TRPM_SLOG
PANTHERiPTHR13800:SF2 PTHR13800:SF2, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PTA2
Secondary accession number(s): Q2PH54, Q5G856
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: July 22, 2015
Last modified: April 22, 2020
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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