Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

72 kDa type IV collagenase

Gene

Mmp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei404UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandCalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1474228 Degradation of the extracellular matrix
R-RNO-1592389 Activation of Matrix Metalloproteinases
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Submitted name:
72 kDa type IV collagenaseImported
Gene namesi
Name:Mmp2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621316 Mmp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501356823230 – 663Sequence analysisAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi233 ↔ 259PROSITE-ProRule annotation
Disulfide bondi247 ↔ 274PROSITE-ProRule annotation
Disulfide bondi291 ↔ 317PROSITE-ProRule annotation
Disulfide bondi305 ↔ 332PROSITE-ProRule annotation
Disulfide bondi349 ↔ 375PROSITE-ProRule annotation
Disulfide bondi363 ↔ 390PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiE9PSM5

Expressioni

Gene expression databases

BgeeiENSRNOG00000016695 Expressed in 10 organ(s), highest expression level in lung

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 276Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini286 – 334Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini344 – 392Fibronectin type-IIInterPro annotationAdd BLAST49
Repeati474 – 519HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati520 – 566HemopexinPROSITE-ProRule annotationAdd BLAST47
Repeati568 – 616HemopexinPROSITE-ProRule annotationAdd BLAST49
Repeati617 – 663HemopexinPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00910000144034
OMAiHESCTSA
OrthoDBiEOG091G03DP
TreeFamiTF315428

Family and domain databases

CDDicd00062 FN2, 3 hits
cd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.10.10.10, 3 hits
2.110.10.10, 1 hit
3.40.390.10, 2 hits
InterProiView protein in InterPro
IPR028708 72kDa_collagenase
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR013806 Kringle-like
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF29 PTHR10201:SF29, 4 hits
PfamiView protein in Pfam
PF00040 fn2, 3 hits
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 2 hits
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00059 FN2, 3 hits
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
SSF57440 SSF57440, 3 hits
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 3 hits
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

E9PSM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARLVWGVL VGPLRVLCVL CCLLGHAIAA PSPIIKFPGD VSPKTDKELA
60 70 80 90 100
VQYLNTFYGC PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP
110 120 130 140 150
RCGNPDVANY NFFPRKPKWD KNQITYRIIG YTPDLDPETV DDAFARALKV
160 170 180 190 200
WSDVTPLRFS RIHDGEADIM INFGRWEHGD GYPFDGKDGL LAHAFAPGTG
210 220 230 240 250
VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN GREYSSCTDT
260 270 280 290 300
GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNGDGQP CKFPFRFQGT
310 320 330 340 350
SYNSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV
360 370 380 390 400
FPFTFLGNKY ESCTSAGRSD GKVWCATTTN YDDDRKWGFC PDQGYSLFLV
410 420 430 440 450
AAHEFGHAMG LEHSQDPGAL MAPIYTYTKN FRLSNDDIKG IQELYGPSPD
460 470 480 490 500
ADTDTGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT
510 520 530 540 550
PRDKPTGPLL VATSFWPELP EKIDAVYEAP QEEKAVFFAG NEYWVYSAST
560 570 580 590 600
LERGYPKPLT SLGLPPDVQQ VDAAFNWSKN KKTYIFSGDK FWRYNEVKKK
610 620 630 640 650
MDPGFPKLIA DSWNAIPDNL DAVVDLQGGG HSYFFKGAYY LKLENQSLKS
660
VKFGSIKSDW LGC
Length:663
Mass (Da):74,237
Last modified:July 22, 2015 - v3
Checksum:iF315B71CD1A1726E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P33436MMP2_RAT
72 kDa type IV collagenase
Mmp2
662Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07042987 Genomic DNA No translation available.
AABR07042988 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000022679; ENSRNOP00000022679; ENSRNOG00000016695

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07042987 Genomic DNA No translation available.
AABR07042988 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PSM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022679; ENSRNOP00000022679; ENSRNOG00000016695

Organism-specific databases

RGDi621316 Mmp2

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00910000144034
OMAiHESCTSA
OrthoDBiEOG091G03DP
TreeFamiTF315428

Enzyme and pathway databases

ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1474228 Degradation of the extracellular matrix
R-RNO-1592389 Activation of Matrix Metalloproteinases
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-3928665 EPH-ephrin mediated repulsion of cells

Gene expression databases

BgeeiENSRNOG00000016695 Expressed in 10 organ(s), highest expression level in lung

Family and domain databases

CDDicd00062 FN2, 3 hits
cd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.10.10.10, 3 hits
2.110.10.10, 1 hit
3.40.390.10, 2 hits
InterProiView protein in InterPro
IPR028708 72kDa_collagenase
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR013806 Kringle-like
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF29 PTHR10201:SF29, 4 hits
PfamiView protein in Pfam
PF00040 fn2, 3 hits
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 2 hits
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00059 FN2, 3 hits
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
SSF57440 SSF57440, 3 hits
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 3 hits
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9PSM5_RAT
AccessioniPrimary (citable) accession number: E9PSM5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 67 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again