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Protein
Submitted name:

Caspase 4

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • apoptotic process Source: RGD
  • ectopic germ cell programmed cell death Source: Ensembl
  • inflammatory response Source: RGD
  • positive regulation of interleukin-1 beta secretion Source: Ensembl
  • pyroptosis Source: Ensembl
  • regulation of inflammatory response Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-168638 NOD1/2 Signaling Pathway

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 4Imported
Gene namesi
Name:Casp4Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621757 Casp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiE9PSM0
PeptideAtlasiE9PSM0

Expressioni

Gene expression databases

BgeeiENSRNOG00000033697

Interactioni

GO - Molecular functioni

  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 241CASPASE_P20InterPro annotationAdd BLAST129
Domaini269 – 354CASPASE_P10InterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00910000144131
InParanoidiE9PSM0
OMAiFFNIDQI
OrthoDBiEOG091G07NO

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

E9PSM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VGGELLREAD SWVTKHVLKL KEEEKQKFNN AERSDKRWVF VDVLKRKHNQ
60 70 80 90 100
VGKMLLQTFL NVDSGSHHGE ANLEMEEPEE SVDTLKLCSS EEFTRLCREK
110 120 130 140 150
KQEIYPIKET NGRTRKALII CNTEFKHLSL RYGANIDISG MKGLLEELGY
160 170 180 190 200
DVVVKEELTA EGMESEMKDF AALSEHQTSD STFLVLMSHG TLQGLCGTMH
210 220 230 240 250
SEATPDVLLY DTIYQIFNNC HCPGLRDKPK VIIVQACRGG NPGEVWIRES
260 270 280 290 300
SGAHSYRAVD LPRNMEADAV RMSHVEKDFI ALYSTTPHHL SYRDKTRGSY
310 320 330 340 350
FISKLISCFR IHACSCHLFD IFLKVQQSFE KASINSQMPT IDRATLTRYF

YLFPGN
Length:356
Mass (Da):40,653
Last modified:July 22, 2015 - v3
Checksum:i1FE190304929A3FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068940 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000061973; ENSRNOP00000058685; ENSRNOG00000033697

Similar proteinsi

Entry informationi

Entry nameiE9PSM0_RAT
AccessioniPrimary (citable) accession number: E9PSM0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: July 22, 2015
Last modified: June 20, 2018
This is version 61 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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