Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 82 (12 Aug 2020)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Citron rho-interacting kinase

Gene

Cit

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in cytokinesis (By similarity). Required for KIF14 localization to the central spindle and midbody (By similarity). Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1 (By similarity). It probably binds p21 with a tighter specificity in vivo (By similarity). Displays serine/threonine protein kinase activity (By similarity). Plays an important role in the regulation of cytokinesis and the development of the central nervous system (PubMed:24695496). Phosphorylates MYL9/MLC2 (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei126ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei221Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi103 – 111ATPPROSITE-ProRule annotation9
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1388 – 1437Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5625900, RHO GTPases activate CIT

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Citron rho-interacting kinaseBy similarity (EC:2.7.11.1By similarity)
Short name:
CRIKBy similarity
Alternative name(s):
Rho-interacting, serine/threonine-protein kinase 21By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CitImported
Synonyms:CRIKBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
70878, Cit

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004486981 – 2055Citron rho-interacting kinaseAdd BLAST2055

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9PSL7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9PSL7

PRoteomics IDEntifications database

More...
PRIDEi
E9PSL7

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9PSL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001143, Expressed in brain and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9PSL7, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form) (By similarity).

Interacts with TTC3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
E9PSL7, 5 interactors

Molecular INTeraction database

More...
MINTi
E9PSL7

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000053869

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9PSL7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 359Protein kinasePROSITE-ProRule annotationAdd BLAST263
Domaini360 – 430AGC-kinase C-terminalAdd BLAST71
Domaini1469 – 1589PHPROSITE-ProRule annotationAdd BLAST121
Domaini1617 – 1907CNHPROSITE-ProRule annotationAdd BLAST291

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili457 – 747Sequence analysisAdd BLAST291
Coiled coili773 – 1238Sequence analysisAdd BLAST466
Coiled coili1284 – 1318Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1388 – 1437Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0612, Eukaryota
KOG0976, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_140_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9PSL7

KEGG Orthology (KO)

More...
KOi
K16308

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSLYFMA

Database of Orthologous Groups

More...
OrthoDBi
759391at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9PSL7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd05601, STKc_CRIK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR017405, Citron_Rho-interacting_kinase
IPR001180, CNH_dom
IPR037708, CRIK_dom
IPR011009, Kinase-like_dom_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR22988:SF26, PTHR22988:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780, CNH, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038145, Citron_Rho-interacting_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00036, CNH, 1 hit
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50219, CNH, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: E9PSL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKFKYGVRN PSEASAPEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG
60 70 80 90 100
VLDALFVLLE ECSQPALMKI KHVSSFVRKY SDTIAELREL QPSVRDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DVYAMKIMKK AALRAQEQVS FFEEERNILS
160 170 180 190 200
QSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DLLSLLNRYE DQLDENMIQF
210 220 230 240 250
YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF GSAAKMNSNK
260 270 280 290 300
VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMLYGKT
310 320 330 340 350
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLIQSL LCVQKERLKF
360 370 380 390 400
EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSP
410 420 430 440 450
CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSGLDSP AKISSMEKKL
460 470 480 490 500
LIKSKELQDS QDKCHKMEQE MARLHRRVSE VEAVLSQKEV ELKASETQRS
510 520 530 540 550
LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE
560 570 580 590 600
IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR
610 620 630 640 650
KANECQHKLM KAKDLGKPEV GECSRLEKIN AEQQLKIQEL QEKLEKAVKA
660 670 680 690 700
STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE
710 720 730 740 750
NKVKRLETME RRENRLKDDI QTKSEQIQQM ADKILELEEK HREAQVSAQH
760 770 780 790 800
LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK ESLETMMQRH EEEAHEKGKI
810 820 830 840 850
LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ RNMKAQEEMI
860 870 880 890 900
SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKN RLLELETRLR
910 920 930 940 950
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT
960 970 980 990 1000
ELEETTAEAE EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED
1010 1020 1030 1040 1050
NAELNNQNFY LSKQLDEASG ANDEIVQLRS EVDHLRREIT EREMQLTSQK
1060 1070 1080 1090 1100
QTMEALKTTC TMLEEQVMDL EALNDELLEK ERQWEAWRSV LGDEKSQFEC
1110 1120 1130 1140 1150
RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE ILALQQALKE
1160 1170 1180 1190 1200
QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL
1210 1220 1230 1240 1250
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK
1260 1270 1280 1290 1300
VKMEGTISQQ TKLIDFLQAK MDQPAKKKKV PLQYNELKLA LEKEKARCAE
1310 1320 1330 1340 1350
LEEALQKTRI ELRSAREEAA HRKATDHPHP STPATARQQI AMSAIVRSPE
1360 1370 1380 1390 1400
HQPSAMSLLA PPSSRRKEAS TPEEFSRRLK ERMHHNIPHR FNVGLNMRAT
1410 1420 1430 1440 1450
KCAVCLDTVH FGRQASKCLE CQVMCHPKCS TCLPATCGLP AEYATHFTEA
1460 1470 1480 1490 1500
FCRDKVSSPG LQSKEPSSSL HLEGWMKVPR NNKRGQQGWD RKYIVLEGSK
1510 1520 1530 1540 1550
VLIYDNEARE AGQRPVEEFE LCLPDGDVSI HGAVGASELA NTAKADVPYI
1560 1570 1580 1590 1600
LKMESHPHTT CWPGRTLYLL APSFPDKQRW VTALESVVAG GRVSREKAEA
1610 1620 1630 1640 1650
DAKLLGNSLL KLEGDDRLDM NCTLPFSDQV VLVGTEEGLY ALNVLKNSLT
1660 1670 1680 1690 1700
HIPGIGAVFQ IYIIKDLEKL LMIAGEERAL CLVDVKKVKQ SLAQSHLPAQ
1710 1720 1730 1740 1750
PDVSPNIFEA VKGCHLFAAG KIENSLCICA AMPSKVVILR YNDNLSKFCI
1760 1770 1780 1790 1800
RKEIETSEPC SCIHFTNYSI LIGTNKFYEI DMKQYTLEEF LDKNDHSLAP
1810 1820 1830 1840 1850
AVFASSTNSF PVSIVQANST GQREEYLLCF HEFGVFVDSY GRRSRTDDLK
1860 1870 1880 1890 1900
WSRLPLAFAY REPYLFVTHF NSLEVIEIQA RSSLGTPARA YLEIPNPRYL
1910 1920 1930 1940 1950
GPAISSGAIY LASSYQDKLR VICCKGNLVK ESGTEQHRVP STSRSSPNKR
1960 1970 1980 1990 2000
GPPTYNEHIT KRVASSPAPP EGPSHPREPS TPHRYRDREG RTELRRDKSP
2010 2020 2030 2040 2050
GRPLEREKSP GRMLSTRRER SPGRLFEDSS RGRLPAGAVR TPLSQVNKVW

DQSSV
Length:2,055
Mass (Da):235,310
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i237329B7CF7C0596
GO
Isoform 2 (identifier: E9PSL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-466: Missing.
     1279-1279: K → KGLFSRRKEDPALPTQ
     1602-1602: A → AAWDCTSCERLPVWVE
     1945-1945: Missing.

Show »
Length:1,618
Mass (Da):185,926
Checksum:iEAED8079788AA4E9
GO
Isoform 3 (identifier: E9PSL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1602-1602: A → AAWDCTSCERLPVWVE
     1945-1945: Missing.

Show »
Length:2,069
Mass (Da):236,999
Checksum:iAC5197FC643416A8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0604301 – 466Missing in isoform 2. Add BLAST466
Alternative sequenceiVSP_0604311279K → KGLFSRRKEDPALPTQ in isoform 2. 1
Alternative sequenceiVSP_0604321602A → AAWDCTSCERLPVWVE in isoform 2 and isoform 3. 1
Alternative sequenceiVSP_0604331945Missing in isoform 2 and isoform 3. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF039218 mRNA Translation: AAC25483.1
AABR07036527 Genomic DNA No translation available.
AABR07036528 Genomic DNA No translation available.
AABR07036529 Genomic DNA No translation available.
AABR07036530 Genomic DNA No translation available.
AABR07036531 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001025082.1, NM_001029911.1 [E9PSL7-1]
XP_006249534.1, XM_006249472.3 [E9PSL7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000041281; ENSRNOP00000043901; ENSRNOG00000001143 [E9PSL7-2]
ENSRNOT00000057036; ENSRNOP00000053869; ENSRNOG00000001143 [E9PSL7-1]
ENSRNOT00000086716; ENSRNOP00000069808; ENSRNOG00000001143 [E9PSL7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:83620

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039218 mRNA Translation: AAC25483.1
AABR07036527 Genomic DNA No translation available.
AABR07036528 Genomic DNA No translation available.
AABR07036529 Genomic DNA No translation available.
AABR07036530 Genomic DNA No translation available.
AABR07036531 Genomic DNA No translation available.
RefSeqiNP_001025082.1, NM_001029911.1 [E9PSL7-1]
XP_006249534.1, XM_006249472.3 [E9PSL7-1]

3D structure databases

SMRiE9PSL7
ModBaseiSearch...

Protein-protein interaction databases

IntActiE9PSL7, 5 interactors
MINTiE9PSL7
STRINGi10116.ENSRNOP00000053869

PTM databases

PhosphoSitePlusiE9PSL7

Proteomic databases

jPOSTiE9PSL7
PaxDbiE9PSL7
PRIDEiE9PSL7

Genome annotation databases

EnsembliENSRNOT00000041281; ENSRNOP00000043901; ENSRNOG00000001143 [E9PSL7-2]
ENSRNOT00000057036; ENSRNOP00000053869; ENSRNOG00000001143 [E9PSL7-1]
ENSRNOT00000086716; ENSRNOP00000069808; ENSRNOG00000001143 [E9PSL7-3]
GeneIDi83620
KEGGirno:83620

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11113
RGDi70878, Cit

Phylogenomic databases

eggNOGiKOG0612, Eukaryota
KOG0976, Eukaryota
GeneTreeiENSGT00990000203528
HOGENOMiCLU_000288_140_2_1
InParanoidiE9PSL7
KOiK16308
OMAiQSLYFMA
OrthoDBi759391at2759
PhylomeDBiE9PSL7

Enzyme and pathway databases

ReactomeiR-RNO-5625900, RHO GTPases activate CIT

Gene expression databases

BgeeiENSRNOG00000001143, Expressed in brain and 20 other tissues
ExpressionAtlasiE9PSL7, baseline and differential

Family and domain databases

CDDicd00029, C1, 1 hit
cd05601, STKc_CRIK, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR017405, Citron_Rho-interacting_kinase
IPR001180, CNH_dom
IPR037708, CRIK_dom
IPR011009, Kinase-like_dom_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR22988:SF26, PTHR22988:SF26, 1 hit
PfamiView protein in Pfam
PF00780, CNH, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PIRSFiPIRSF038145, Citron_Rho-interacting_kinase, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00036, CNH, 1 hit
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50219, CNH, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTRO_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PSL7
Secondary accession number(s): A0A0G2JWA9, Q9QX19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: April 5, 2011
Last modified: August 12, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again