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UniProtKB - E9PS75 (E9PS75_HUMAN)
Protein
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Gene
MACF1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported |
Gene namesi | Name:MACF1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13664, MACF1 |
VEuPathDBi | HostDB:ENSG00000127603 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 29 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000127603, Expressed in corpus callosum and 250 other tissues |
ExpressionAtlasi | E9PS75, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 113 | Calponin-homology (CH)InterPro annotationAdd BLAST | 73 |
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155824 |
HOGENOMi | CLU_2139105_0_0_1 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF00307, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
E9PS75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLLDSSYLP PTIFILTHVL GVAGVLYWKR HARGRADERD RVQKKTFTKW
60 70 80 90 100
VNKHLMKVRK HINDLYEDLR DGHNLISLLE VLSGIKLPRE KGRMRFHRLQ
110
NVQIALDFLK QRQ
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UPN3 | MACF1_HUMAN | Microtubule-actin cross-linking fac... | MACF1 ABP620, ACF7, KIAA0465, KIAA1251 | 7,388 | Annotation score: | ||
H3BPE1 | H3BPE1_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 7,555 | Annotation score: | ||
H3BQK9 | H3BQK9_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 7,592 | Annotation score: | ||
A0A590UJG2 | A0A590UJG2_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 5,379 | Annotation score: | ||
A0A7P0MQR8 | A0A7P0MQR8_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 7,385 | Annotation score: | ||
H0Y390 | H0Y390_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 4,434 | Annotation score: | ||
A0A0A6YYJ5 | A0A0A6YYJ5_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 1,668 | Annotation score: | ||
H0Y314 | H0Y314_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 543 | Annotation score: | ||
A0A5F9ZGX0 | A0A5F9ZGX0_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 2,146 | Annotation score: | ||
H0Y4F5 | H0Y4F5_HUMAN | Microtubule-actin cross-linking fac... | MACF1 | 455 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 113 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137853 Genomic DNA No translation available. AL355477 Genomic DNA No translation available. AL356055 Genomic DNA No translation available. AL365277 Genomic DNA No translation available. AL442071 Genomic DNA No translation available. KF495921 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000494012; ENSP00000435892; ENSG00000127603 |
UCSCi | uc057fac.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137853 Genomic DNA No translation available. AL355477 Genomic DNA No translation available. AL356055 Genomic DNA No translation available. AL365277 Genomic DNA No translation available. AL442071 Genomic DNA No translation available. KF495921 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PS75 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9PS75 |
PeptideAtlasi | E9PS75 |
ProteomicsDBi | 23529 |
Protocols and materials databases
Antibodypediai | 31853, 66 antibodies from 18 providers |
Genome annotation databases
Ensembli | ENST00000494012; ENSP00000435892; ENSG00000127603 |
UCSCi | uc057fac.1, human |
Organism-specific databases
HGNCi | HGNC:13664, MACF1 |
OpenTargetsi | ENSG00000127603 |
VEuPathDBi | HostDB:ENSG00000127603 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155824 |
HOGENOMi | CLU_2139105_0_0_1 |
Miscellaneous databases
ChiTaRSi | MACF1, human |
Gene expression databases
Bgeei | ENSG00000127603, Expressed in corpus callosum and 250 other tissues |
ExpressionAtlasi | E9PS75, baseline and differential |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF00307, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS50021, CH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PS75_HUMAN | |
Accessioni | E9PS75Primary (citable) accession number: E9PS75 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |