UniProtKB - E9PRQ8 (E9PRQ8_HUMAN)
Protein
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2
Gene
EFEMP2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- elastic fiber assembly Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: EGF-containing fibulin-like extracellular matrix protein 2Imported |
Gene namesi | Name:EFEMP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3219, EFEMP2 |
VEuPathDBi | HostDB:ENSG00000172638.12 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5003244191 | 28 – 183 | Sequence analysisAdd BLAST | 156 |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
PeptideAtlasi | E9PRQ8 |
ProteomicsDBi | 23384 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172638, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | E9PRQ8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 123 – 163 | EGF-likeInterPro annotationAdd BLAST | 41 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159437 |
HOGENOMi | CLU_1485250_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR026824, Efemp2 IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24034:SF96, PTHR24034:SF96, 1 hit |
Pfami | View protein in Pfam PF07645, EGF_CA, 2 hits |
SMARTi | View protein in SMART SM00181, EGF, 1 hit SM00179, EGF_CA, 3 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
E9PRQ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ
60 70 80 90 100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV
110 120 130 140 150
PPAQHPNPCP PGYEPDDQDS CVDVDECAQA LHDCRPSQDC HNLPGSYQCT
160 170 180
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGS
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO95967 | FBLN4_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 FBLN4, UNQ200/PRO226 | 443 | Annotation score: | ||
E9PRU1 | E9PRU1_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 436 | Annotation score: | ||
E9PKA3 | E9PKA3_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 202 | Annotation score: | ||
H0YET5 | H0YET5_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 182 | Annotation score: | ||
E9PSC1 | E9PSC1_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 77 | Annotation score: | ||
E9PI47 | E9PI47_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 76 | Annotation score: | ||
H0YCR9 | H0YCR9_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 69 | Annotation score: | ||
H0YEU0 | H0YEU0_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 74 | Annotation score: | ||
H0YCB5 | H0YCB5_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 54 | Annotation score: | ||
E9PNB8 | E9PNB8_HUMAN | EGF-containing fibulin-like extrace... | EFEMP2 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 183 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001201 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000527378; ENSP00000435963; ENSG00000172638 |
UCSCi | uc058drc.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001201 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PRQ8 |
ProteomicsDBi | 23384 |
Protocols and materials databases
Antibodypediai | 16033, 359 antibodies |
Genome annotation databases
Ensembli | ENST00000527378; ENSP00000435963; ENSG00000172638 |
UCSCi | uc058drc.1, human |
Organism-specific databases
HGNCi | HGNC:3219, EFEMP2 |
OpenTargetsi | ENSG00000172638 |
VEuPathDBi | HostDB:ENSG00000172638.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159437 |
HOGENOMi | CLU_1485250_0_0_1 |
Miscellaneous databases
ChiTaRSi | EFEMP2, human |
Gene expression databases
Bgeei | ENSG00000172638, Expressed in stromal cell of endometrium and 241 other tissues |
ExpressionAtlasi | E9PRQ8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026824, Efemp2 IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf |
PANTHERi | PTHR24034:SF96, PTHR24034:SF96, 1 hit |
Pfami | View protein in Pfam PF07645, EGF_CA, 2 hits |
SMARTi | View protein in SMART SM00181, EGF, 1 hit SM00179, EGF_CA, 3 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PRQ8_HUMAN | |
Accessioni | E9PRQ8Primary (citable) accession number: E9PRQ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |