Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

EFEMP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Gene namesi
Name:EFEMP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172638.12
HGNCiHGNC:3219 EFEMP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172638

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500324419128 – 183Sequence analysisAdd BLAST156

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiE9PRQ8
PRIDEiE9PRQ8

Expressioni

Gene expression databases

BgeeiENSG00000172638 Expressed in 230 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiE9PRQ8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PRQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 163EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U Eukaryota
ENOG410ZNNG LUCA
GeneTreeiENSGT00760000118806

Family and domain databases

InterProiView protein in InterPro
IPR026824 Efemp2
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF3 PTHR44074:SF3, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 3 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

E9PRQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ
60 70 80 90 100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV
110 120 130 140 150
PPAQHPNPCP PGYEPDDQDS CVDVDECAQA LHDCRPSQDC HNLPGSYQCT
160 170 180
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGS
Length:183
Mass (Da):20,095
Last modified:April 5, 2011 - v1
Checksum:i661C7B0967499D54
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95967FBLN4_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2 FBLN4, UNQ200/PRO226
443Annotation score:
E9PRU1E9PRU1_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
436Annotation score:
E9PKA3E9PKA3_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
202Annotation score:
E9PSC1E9PSC1_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
77Annotation score:
H0YET5H0YET5_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
182Annotation score:
H0YEU0H0YEU0_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
74Annotation score:
E9PI47E9PI47_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
76Annotation score:
H0YCR9H0YCR9_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
69Annotation score:
H0YCB5H0YCB5_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
54Annotation score:
E9PNB8E9PNB8_HUMAN
EGF-containing fibulin-like extrace...
EFEMP2
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei183Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001201 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000527378; ENSP00000435963; ENSG00000172638
UCSCiuc058drc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001201 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PRQ8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PRQ8
PRIDEiE9PRQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527378; ENSP00000435963; ENSG00000172638
UCSCiuc058drc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000172638.12
HGNCiHGNC:3219 EFEMP2
OpenTargetsiENSG00000172638
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR6U Eukaryota
ENOG410ZNNG LUCA
GeneTreeiENSGT00760000118806

Gene expression databases

BgeeiENSG00000172638 Expressed in 230 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiE9PRQ8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026824 Efemp2
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF3 PTHR44074:SF3, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00179 EGF_CA, 3 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PRQ8_HUMAN
AccessioniPrimary (citable) accession number: E9PRQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again