UniProtKB - E9PQT7 (E9PQT7_HUMAN)
Protein
Submitted name:
Ubiquitin/ISG15-conjugating enzyme E2 L6
Gene
UBE2L6
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 93 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- transferase activity Source: UniProtKB-KW
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | E9PQT7 |
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin/ISG15-conjugating enzyme E2 L6Imported |
Gene namesi | Name:UBE2L6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12490, UBE2L6 |
VEuPathDBi | HostDB:ENSG00000156587.15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156587, Expressed in granulocyte and 238 other tissues |
ExpressionAtlasi | E9PQT7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 127 | UBC coreInterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000161981 |
HOGENOMi | CLU_030988_16_0_1 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9PQT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRWTWKASW SRWLAFELED LQKKPPPYLR NLSSDDANVL VWHALLLPDQ
60 70 80 90 100
PPYHLKAFNL RISFPPEYPF KPPMIKFTTK IYHPNVDENG QICLPIISSE
110 120
NWKPCTKTCQ VLEALNVLVN RPNIREP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14933 | UB2L6_HUMAN | Ubiquitin/ISG15-conjugating enzyme ... | UBE2L6 UBCH8 | 153 | Annotation score: | ||
E9PKW8 | E9PKW8_HUMAN | Ubiquitin/ISG15-conjugating enzyme ... | UBE2L6 | 65 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 127 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002893 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000526659; ENSP00000434348; ENSG00000156587 |
UCSCi | uc058bmt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002893 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PQT7 |
PRIDEi | E9PQT7 |
ProteomicsDBi | 23115 |
Protocols and materials databases
Antibodypediai | 1142, 342 antibodies |
Genome annotation databases
Ensembli | ENST00000526659; ENSP00000434348; ENSG00000156587 |
UCSCi | uc058bmt.1, human |
Organism-specific databases
HGNCi | HGNC:12490, UBE2L6 |
OpenTargetsi | ENSG00000156587 |
VEuPathDBi | HostDB:ENSG00000156587.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161981 |
HOGENOMi | CLU_030988_16_0_1 |
Enzyme and pathway databases
SignaLinki | E9PQT7 |
Miscellaneous databases
ChiTaRSi | UBE2L6, human |
Gene expression databases
Bgeei | ENSG00000156587, Expressed in granulocyte and 238 other tissues |
ExpressionAtlasi | E9PQT7, baseline and differential |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PQT7_HUMAN | |
Accessioni | E9PQT7Primary (citable) accession number: E9PQT7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |