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Protein

Nuclear transcription factor Y subunit gamma

Gene

NFYC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gammaUniRule annotation
Alternative name(s):
Nuclear transcription factor Y subunit CUniRule annotation
Gene namesi
Name:NFYCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000066136.19
HGNCiHGNC:7806 NFYC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066136

PTM / Processingi

Proteomic databases

MaxQBiE9PQR2
PeptideAtlasiE9PQR2
PRIDEiE9PQR2

Expressioni

Gene expression databases

BgeeiENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiE9PQR2 baseline and differential

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PQR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 59CBFD_NFYB_HMFInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E9PQR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK
60
IMKLDEDVKM
Length:60
Mass (Da):6,861
Last modified:April 5, 2011 - v1
Checksum:i8192321458FC4780
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13952NFYC_HUMAN
Nuclear transcription factor Y subu...
NFYC
458Annotation score:
Q5T6K5Q5T6K5_HUMAN
Nuclear transcription factor Y subu...
NFYC
313Annotation score:
Q5T6K7Q5T6K7_HUMAN
Nuclear transcription factor Y subu...
NFYC
129Annotation score:
E9PI99E9PI99_HUMAN
Nuclear transcription factor Y subu...
NFYC
141Annotation score:
E9PL11E9PL11_HUMAN
Nuclear transcription factor Y subu...
NFYC
95Annotation score:
E9PJA8E9PJA8_HUMAN
Nuclear transcription factor Y subu...
NFYC
52Annotation score:
A0A0A0MT00A0A0A0MT00_HUMAN
Nuclear transcription factor Y subu...
NFYC
179Annotation score:
H0Y803H0Y803_HUMAN
Nuclear transcription factor Y subu...
NFYC
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei60Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119677 Genomic DNA No translation available.
AL031289 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
KF495918 Genomic DNA No translation available.
KF495929 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000531464; ENSP00000434404; ENSG00000066136
UCSCiuc057fgl.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119677 Genomic DNA No translation available.
AL031289 Genomic DNA No translation available.
AL354914 Genomic DNA No translation available.
KF495918 Genomic DNA No translation available.
KF495929 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PQR2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PQR2
PeptideAtlasiE9PQR2
PRIDEiE9PQR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531464; ENSP00000434404; ENSG00000066136
UCSCiuc057fgl.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000066136.19
HGNCiHGNC:7806 NFYC
OpenTargetsiENSG00000066136
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00530000063560

Miscellaneous databases

ChiTaRSiNFYC human

Gene expression databases

BgeeiENSG00000066136 Expressed in 236 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiE9PQR2 baseline and differential

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
IPR027170 NFYC/HAP5_su
PANTHERiPTHR10252:SF8 PTHR10252:SF8, 1 hit
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PQR2_HUMAN
AccessioniPrimary (citable) accession number: E9PQR2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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