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Protein
Submitted name:

Non-receptor tyrosine-protein kinase TYK2

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Non-receptor tyrosine-protein kinase TYK2Imported
Gene namesi
Name:TYK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105397

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PQL2
PRIDEiE9PQL2

Expressioni

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiE9PQL2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PQL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 118FERMInterPro annotationAdd BLAST93

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Family and domain databases

InterProiView protein in InterPro
IPR000299 FERM_domain
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

E9PQL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRHWGMAR GSKPVGDGAQ PMAAMGGLKV LLHWAGPGGG EPWVTFSESS
60 70 80 90 100
LTAEEVCIHI AHKVGITPPC FNLFALFDAQ AQVWLPPNHI LEIPRDASLM
110
LYFRIRFYFR NWHGMNPR
Length:118
Mass (Da):13,223
Last modified:April 5, 2011 - v1
Checksum:i8765E8BB970345AC
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P29597TYK2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
1,187Annotation score:
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:
E9PM19E9PM19_HUMAN
Tyrosine-protein kinase
TYK2
1,002Annotation score:
K7EJR6K7EJR6_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
142Annotation score:
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:
H0YE41H0YE41_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
194Annotation score:
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei118Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000531836; ENSP00000436175; ENSG00000105397
UCSCiuc060thz.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PQL2_HUMAN
AccessioniPrimary (citable) accession number: E9PQL2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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