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UniProtKB - E9PNZ4 (E9PNZ4_HUMAN)

Entry version 80 (19 Jan 2022)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13664, MACF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		E9PNZ4

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9PNZ4

PeptideAtlas

More...PeptideAtlasi		E9PNZ4

PRoteomics IDEntifications database

More...PRIDEi		E9PNZ4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		22568

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127603, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E9PNZ4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		E9PNZ4, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9PNZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini343 – 447Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini1017 – 1074SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 60DisorderedSequence analysisAdd BLAST35
Regioni72 – 95DisorderedSequence analysisAdd BLAST24
Regioni203 – 229DisorderedSequence analysisAdd BLAST27
Regioni250 – 279DisorderedSequence analysisAdd BLAST30
Regioni291 – 324DisorderedSequence analysisAdd BLAST34
Regioni1985 – 2005DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili394 – 414Sequence analysisAdd BLAST21
Coiled coili626 – 646Sequence analysisAdd BLAST21
Coiled coili651 – 678Sequence analysisAdd BLAST28
Coiled coili970 – 990Sequence analysisAdd BLAST21
Coiled coili1195 – 1215Sequence analysisAdd BLAST21
Coiled coili1552 – 1582Sequence analysisAdd BLAST31
Coiled coili1646 – 1666Sequence analysisAdd BLAST21
Coiled coili1671 – 1698Sequence analysisAdd BLAST28
Coiled coili1778 – 1812Sequence analysisAdd BLAST35
Coiled coili1942 – 1972Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi208 – 229Polar residuesSequence analysisAdd BLAST22
Compositional biasi262 – 279Polar residuesSequence analysisAdd BLAST18
Compositional biasi305 – 319Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_233447_0_0_1

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 1 hit
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit
SM00150, SPEC, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50021, CH, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

E9PNZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSLGCFKE PKESIAIPEK APISPKKRVR FKRRWRGKKI PTPEASHQEE 
        60         70         80         90        100
TSEGTGVIEE TETLTKLTES LQKEDGVGGV EHTPPDILLP GDSAPNSRVV 
       110        120        130        140        150
DRGMIVQVKE RFQGEVQTAH LLLENESSVA GGVWDSLEEG MTVIAHLLDN 
       160        170        180        190        200
PAERNCEKSV SQLVEFPRTA SCSSRAVLLP LQGETAVEKG NIQRGFRSCA 
       210        220        230        240        250
LPRTDYPTDK GNQEQFSEGW SVEEGTKSVS GAPQTASWII ECSVSSLLLD 
       260        270        280        290        300
QPGGQRRTEP SHVGQVPPQD SRLPTSQSDL SISGVTVSIL PSSSGYGSDG 
       310        320        330        340        350
PHIHGIQPKD TEPEKSSTSF SEEDGTLSLE ISDIYISGES GDMSAKEKLL 
       360        370        380        390        400
LWTQKVTAGY TGIKCTNFSS CWSDGKMFNA LIHRYRPDLV DMERVQIQSN 
       410        420        430        440        450
RENLEQAFEV AERLGVTRLL DAEDVDVPSP DEKSVITYVS SIYDAFPKVP 
       460        470        480        490        500
EGGEGISATE VDSRWQEYQS RVDSLIPWIK QHTILMSDKT FPQNPVELKA 
       510        520        530        540        550
LYNQYIHFKE TEILAKEREK GRIEELYKLL EVWIEFGRIK LPQGYHPNDV 
       560        570        580        590        600
EEEWGKLIIE MLEREKSLRP AVERLELLLQ IANKIQNGAL NCEEKLTLAK 
       610        620        630        640        650
NTLQADAAHL ESGQPVQCES DVIMYIQECE GLIRQLQVDL QILRDENYYQ 
       660        670        680        690        700
LEELAFRVMR LQDELVTLRL ECTNLYRKGH FTSLELVPPS TLTTTHLKAE 
       710        720        730        740        750
PLTKATHSSS TSWFRKPMTR AELVAISSSE DEGNLRFVYE LLSWVEEMQM 
       760        770        780        790        800
KLERAEWGND LPSVELQLET QQHIHTSVEE LGSSVKEARL YEGKMSQNFH 
       810        820        830        840        850
TSYAETLGKL ETQYCKLKET SSFRMRHLQS LHKFVSRATA ELIWLNEKEE 
       860        870        880        890        900
EELAYDWSDN NSNISAKRNY FSELTMELEE KQDVFRSLQD TAELLSLENH 
       910        920        930        940        950
PAKQTVEAYS AAVQSQLQWM KQLCLCVEQH VKENTAYFQF FSDARELESF 
       960        970        980        990       1000
LRNLQDSIKR KYSCDHNTSL SRLEDLLQDS MDEKEQLIQS KSSVASLVGR 
      1010       1020       1030       1040       1050
SKTIVQLKPR SPDHVLKNTI SVKAVCDYRQ IEITICKNDE CVLEDNSQRT 
      1060       1070       1080       1090       1100
KWKVISPTGN EAMVPSVCFL IPPPNKDAIE MASRVEQSYQ KVMALWHQLH 
      1110       1120       1130       1140       1150
VNTKSLISWN YLRKDLDLVQ TWNLEKLRSS APGECHQIMK NLQAHYEDFL 
      1160       1170       1180       1190       1200
QDSRDSVLFS VADRLRLEEE VEACKARFQH LMKSMENEDK EETVAKMYIS 
      1210       1220       1230       1240       1250
ELKNIRLRLE EYEQRVVKRI QSLASSRTDR DAWQDNALRI AEQEHTQEDL 
      1260       1270       1280       1290       1300
QQLRSDLDAV SMKCDSFLHQ SPSSSSVPTL RSELNLLVEK MDHVYGLSTV 
      1310       1320       1330       1340       1350
YLNKLKTVDV IVRSIQDAEL LVKGYEIKLS QEEVVLADLS ALEAHWSTLR 
      1360       1370       1380       1390       1400
HWLSDVKDKN SVFSVLDEEI AKAKVVAEQM SRLTPERNLD LERYQEKGSQ 
      1410       1420       1430       1440       1450
LQERWHRVIA QLEIRQSELE SIQEVLGDYR ACHGTLIKWI EETTAQQEMM 
      1460       1470       1480       1490       1500
KPGQAEDSRV LSEQLSQQTA LFAEIERNQT KLDQCQKFSQ QYSTIVKDYE 
      1510       1520       1530       1540       1550
LQLMTYKAFV ESQQKSPGKR RRMLSSSDAI TQEFMDLRTR YTALVTLTTQ 
      1560       1570       1580       1590       1600
HVKYISDALR RLEEEEKVVE EEKQEHVEKV KELLGWVSTL ARNTQGKATS 
      1610       1620       1630       1640       1650
SETKESTDIE KAILEQQVLS EELTTKKEQV SEAIKTSQIF LAKHGHKLSE 
      1660       1670       1680       1690       1700
KEKKQISEQL NALNKAYHDL CDGSANQLQQ LQSQLAHQTE QKTLQKQQNT 
      1710       1720       1730       1740       1750
CHQQLEDLCS WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN 
      1760       1770       1780       1790       1800
RATSFATVVK DIEGFMEENQ TKLSPRELTA LREKLHQAKE QYEALQEETR 
      1810       1820       1830       1840       1850
VAQKELEEAV TSALQQETEK SKAAKELAEN KKKIDALLDW VTSVGSSGGQ 
      1860       1870       1880       1890       1900
LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ CEMMKARHQE 
      1910       1920       1930       1940       1950
LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA 
      1960       1970       1980       1990       2000
QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL 
      2010       2020 
PSLLKRQGSF SEDVISHKGD LRFVTISG
Length:2,028
Mass (Da):231,091
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C3EC2D07B664525
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQK9H3BQK9_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,592Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJG2A0A590UJG2_HUMAN
Microtubule-actin cross-linking fac...
MACF1
5,379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0MQR8A0A7P0MQR8_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX0A0A5F9ZGX0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei2028Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000530262; ENSP00000437059; ENSG00000127603

UCSC genome browser

More...UCSCi		uc057fah.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

SMRiE9PNZ4
ModBaseiSearch...

Protein-protein interaction databases

IntActiE9PNZ4, 1 interactor

Proteomic databases

EPDiE9PNZ4
MaxQBiE9PNZ4
PeptideAtlasiE9PNZ4
PRIDEiE9PNZ4
ProteomicsDBi22568

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31853, 66 antibodies from 18 providers

Genome annotation databases

EnsembliENST00000530262; ENSP00000437059; ENSG00000127603
UCSCiuc057fah.1, human

Organism-specific databases

HGNCiHGNC:13664, MACF1
OpenTargetsiENSG00000127603
VEuPathDBiHostDB:ENSG00000127603

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155824
HOGENOMiCLU_233447_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MACF1, human

Gene expression databases

BgeeiENSG00000127603, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiE9PNZ4, baseline and differential

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00150, SPEC, 5 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9PNZ4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9PNZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 19, 2022
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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