UniProtKB - E9PNL3 (E9PNL3_HUMAN)
V-type proton ATPase 21 kDa proteolipid subunit c''
ATP6V0B
Functioni
Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
UniRule annotationCaution
GO - Molecular functioni
- proton-transporting ATPase activity, rotational mechanism Source: InterPro
Keywordsi
Biological process | Ion transportUniRule annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: V-type proton ATPase 21 kDa proteolipid subunit c'' |
Gene namesi | Name:ATP6V0B |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:861, ATP6V0B |
VEuPathDBi | HostDB:ENSG00000117410 |
Subcellular locationi
Other locations
- clathrin-coated vesicle membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting V-type ATPase, V0 domain Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 29 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 49 – 70 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 91 – 115 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 135 – 165 | HelicalUniRule annotationAdd BLAST | 31 | |
Transmembranei | 172 – 196 | HelicalUniRule annotationAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000117410, Expressed in blood and 239 other tissues |
ExpressionAtlasi | E9PNL3, baseline and differential |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 111 | ATP-synt_CInterPro annotationAdd BLAST | 60 | |
Domaini | 138 – 196 | ATP-synt_CInterPro annotationAdd BLAST | 59 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00550000075120 |
OrthoDBi | 1408246at2759 |
PhylomeDBi | E9PNL3 |
Family and domain databases
Gene3Di | 1.20.120.610, 1 hit |
InterProi | View protein in InterPro IPR002379, ATPase_proteolipid_c-like_dom IPR000245, ATPase_proteolipid_csu IPR035921, F/V-ATP_Csub_sf |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 2 hits |
PRINTSi | PR00122, VACATPASE |
SUPFAMi | SSF81333, SSF81333, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS
60 70 80 90 100
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV
110 120 130 140 150
AIYGIIMAIV ISNMAEPFSA TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF
160 170 180 190 200
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQVMN
210 220 230 240 250
PLGKPLCPCP QPSLTLLLEK LKCSPSLPIT IDSPKQLPPP HFHLLVFSYR
260
GSLFLSLIWC H
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ99437 | VATO_HUMAN | V-type proton ATPase 21 kDa proteol... | ATP6V0B ATP6F | 205 | Annotation score: | ||
E9PNU0 | E9PNU0_HUMAN | V-type proton ATPase 21 kDa proteol... | ATP6V0B | 252 | Annotation score: | ||
E9PMR1 | E9PMR1_HUMAN | V-type proton ATPase 21 kDa proteol... | ATP6V0B | 86 | Annotation score: | ||
E9PKB6 | E9PKB6_HUMAN | V-type proton ATPase 21 kDa proteol... | ATP6V0B | 46 | Annotation score: | ||
H0YCC5 | H0YCC5_HUMAN | V-type proton ATPase 21 kDa proteol... | ATP6V0B | 88 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357079 Genomic DNA No translation available. |
RefSeqi | NP_001281262.1, NM_001294333.1 |
Genome annotation databases
Ensembli | ENST00000532642.5; ENSP00000434729.1; ENSG00000117410.14 |
GeneIDi | 533 |
UCSCi | uc057frf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357079 Genomic DNA No translation available. |
RefSeqi | NP_001281262.1, NM_001294333.1 |
3D structure databases
SMRi | E9PNL3 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | E9PNL3 |
Protocols and materials databases
Antibodypediai | 32422, 85 antibodies from 17 providers |
DNASUi | 533 |
Genome annotation databases
Ensembli | ENST00000532642.5; ENSP00000434729.1; ENSG00000117410.14 |
GeneIDi | 533 |
UCSCi | uc057frf.1, human |
Organism-specific databases
CTDi | 533 |
HGNCi | HGNC:861, ATP6V0B |
OpenTargetsi | ENSG00000117410 |
VEuPathDBi | HostDB:ENSG00000117410 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00550000075120 |
OrthoDBi | 1408246at2759 |
PhylomeDBi | E9PNL3 |
Miscellaneous databases
BioGRID-ORCSi | 533, 673 hits in 1084 CRISPR screens |
ChiTaRSi | ATP6V0B, human |
GenomeRNAii | 533 |
Gene expression databases
Bgeei | ENSG00000117410, Expressed in blood and 239 other tissues |
ExpressionAtlasi | E9PNL3, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.610, 1 hit |
InterProi | View protein in InterPro IPR002379, ATPase_proteolipid_c-like_dom IPR000245, ATPase_proteolipid_csu IPR035921, F/V-ATP_Csub_sf |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 2 hits |
PRINTSi | PR00122, VACATPASE |
SUPFAMi | SSF81333, SSF81333, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PNL3_HUMAN | |
Accessioni | E9PNL3Primary (citable) accession number: E9PNL3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |