UniProtKB - E9PNA7 (E9PNA7_HUMAN)
Protein
Anoctamin
Gene
ANO1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- protein dimerization activity Source: InterPro
GO - Biological processi
- cellular response to heat Source: InterPro
- chloride transmembrane transport Source: InterPro
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: AnoctaminUniRule annotation |
Gene namesi | Name:ANO1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21625, ANO1 |
VEuPathDBi | HostDB:ENSG00000131620.17 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 90 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 143 – 162 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 225 – 251 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 271 – 295 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 315 – 336 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 441 – 464 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | E9PNA7 |
PeptideAtlasi | E9PNA7 |
PRIDEi | E9PNA7 |
ProteomicsDBi | 22358 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131620, Expressed in thoracic aorta and 181 other tissues |
ExpressionAtlasi | E9PNA7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 52 | Anoct_dimerInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 660 – 695 | DisorderedSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157182 |
HOGENOMi | CLU_006685_3_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR032394, Anoct_dimer IPR007632, Anoctamin IPR031287, Anoctamin-1 |
PANTHERi | PTHR12308, PTHR12308, 1 hit PTHR12308:SF13, PTHR12308:SF13, 1 hit |
Pfami | View protein in Pfam PF16178, Anoct_dimer, 1 hit PF04547, Anoctamin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PNA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGITSLLANG VYAAAYPLHD GDYNGENVEF NDRKLLYEEW ARYGVFYKYQ
60 70 80 90 100
PIDLVRKYFG EKIGLYFAWL GVYTQMLIPA SIVGIIVFLY GCATMDENIP
110 120 130 140 150
SMEMCDQRHN ITMCPLCDKT CSYWKMSSAC ATARASHLFD NPATVFFSVF
160 170 180 190 200
MALWAATFME HWKRKQMRLN YRWDLTGFEE EEEAVKDHPR AEYEARVLEK
210 220 230 240 250
SLKKESRNKE TDKVKLTWRD RFPAYLTNLV SIIFMIAVTF AIVLGVIIYR
260 270 280 290 300
ISMAAALAMN SSPSVRSNIR VTVTATAVII NLVVIILLDE VYGCIARWLT
310 320 330 340 350
KIEVPKTEKS FEERLIFKAF LLKFVNSYTP IFYVAFFKGR FVGRPGDYVY
360 370 380 390 400
IFRSFRMEEC APGGCLMELC IQLSIIMLGK QLIQNNLFEI GIPKMKKLIR
410 420 430 440 450
YLKLKQQSPP DHEECVKRKQ RYEVDYNLEP FAGLTPEYME MIIQFGFVTL
460 470 480 490 500
FVASFPLAPL FALLNNIIEI RLDAKKFVTE LRRPVAVRAK DIGIWYNILR
510 520 530 540 550
GIGKLAVIIN AFVISFTSDF IPRLVYLYMY SKNGTMHGFV NHTLSSFNVS
560 570 580 590 600
DFQNGTAPND PLDLGYEVQI CRYKDYREPP WSENKYDISK DFWAVLAARL
610 620 630 640 650
AFVIVFQNLV MFMSDFVDWV IPDIPKDISQ QIHKEKVLMV ELFMREEQDK
660 670 680 690
QQLLETWMEK ERQKDEPPCN HHNTKACPDS LGSPAPSHAY HGGVL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5XXA6 | ANO1_HUMAN | Anoctamin-1 | ANO1 DOG1, ORAOV2, TAOS2, TMEM16A | 986 | Annotation score: | ||
H0YDD9 | H0YDD9_HUMAN | Anoctamin | ANO1 | 269 | Annotation score: | ||
E9PP68 | E9PP68_HUMAN | Anoctamin-1 | ANO1 | 251 | Annotation score: | ||
E9PS90 | E9PS90_HUMAN | Anoctamin | ANO1 | 151 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000879 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000531349; ENSP00000432843; ENSG00000131620 |
UCSCi | uc010rqk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000879 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | E9PNA7 |
PeptideAtlasi | E9PNA7 |
PRIDEi | E9PNA7 |
ProteomicsDBi | 22358 |
Protocols and materials databases
Antibodypediai | 30667, 1321 antibodies |
Genome annotation databases
Ensembli | ENST00000531349; ENSP00000432843; ENSG00000131620 |
UCSCi | uc010rqk.3, human |
Organism-specific databases
HGNCi | HGNC:21625, ANO1 |
OpenTargetsi | ENSG00000131620 |
VEuPathDBi | HostDB:ENSG00000131620.17 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157182 |
HOGENOMi | CLU_006685_3_0_1 |
Miscellaneous databases
ChiTaRSi | ANO1, human |
Gene expression databases
Bgeei | ENSG00000131620, Expressed in thoracic aorta and 181 other tissues |
ExpressionAtlasi | E9PNA7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR032394, Anoct_dimer IPR007632, Anoctamin IPR031287, Anoctamin-1 |
PANTHERi | PTHR12308, PTHR12308, 1 hit PTHR12308:SF13, PTHR12308:SF13, 1 hit |
Pfami | View protein in Pfam PF16178, Anoct_dimer, 1 hit PF04547, Anoctamin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PNA7_HUMAN | |
Accessioni | E9PNA7Primary (citable) accession number: E9PNA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |