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Protein
Submitted name:

Tetraspanin-4

Gene

TSPAN4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Submitted name:
Tetraspanin-4Imported
Gene namesi
Name:TSPAN4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000214063.10
HGNCiHGNC:11859 TSPAN4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 36HelicalSequence analysisAdd BLAST25
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214063

PTM / Processingi

Proteomic databases

PRIDEiE9PMX4

Expressioni

Gene expression databases

BgeeiENSG00000214063 Expressed in 219 organ(s), highest expression level in endocervix
ExpressionAtlasiE9PMX4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PMX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

E9PMX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS
60 70 80
LSAANLLIIT GAFVMAIGFV GCLGAIKENK CLLLT
Length:85
Mass (Da):8,865
Last modified:April 5, 2011 - v1
Checksum:i3F48E01F39BC278D
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O14817TSN4_HUMAN
Tetraspanin-4
TSPAN4 NAG2, TM4SF7
238Annotation score:
A8MVV6A8MVV6_HUMAN
Tetraspanin
TSPAN4
174Annotation score:
E9PPX8E9PPX8_HUMAN
Tetraspanin
TSPAN4
159Annotation score:
J3KQ42J3KQ42_HUMAN
Tetraspanin
TSPAN4
257Annotation score:
J3KNL1J3KNL1_HUMAN
Tetraspanin
TSPAN4
204Annotation score:
E9PN41E9PN41_HUMAN
Tetraspanin-4
TSPAN4
132Annotation score:
E9PSH3E9PSH3_HUMAN
Tetraspanin-4
TSPAN4
100Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei85Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006623 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000530404; ENSP00000437266; ENSG00000214063
UCSCiuc057xpf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006623 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PMX4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9PMX4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530404; ENSP00000437266; ENSG00000214063
UCSCiuc057xpf.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000214063.10
HGNCiHGNC:11859 TSPAN4
OpenTargetsiENSG00000214063
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858

Miscellaneous databases

ChiTaRSiTSPAN4 human

Gene expression databases

BgeeiENSG00000214063 Expressed in 219 organ(s), highest expression level in endocervix
ExpressionAtlasiE9PMX4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PMX4_HUMAN
AccessioniPrimary (citable) accession number: E9PMX4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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