UniProtKB - E9PMK8 (E9PMK8_HUMAN)
Protein
Submitted name:
Tripartite motif-containing protein 3
Gene
TRIM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Tripartite motif-containing protein 3Imported |
Gene namesi | Name:TRIM3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10064, TRIM3 |
VEuPathDBi | HostDB:ENSG00000110171.18 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110171, Expressed in right hemisphere of cerebellum and 204 other tissues |
ExpressionAtlasi | E9PMK8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 63 | RING-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 110 – 151 | B box-typeInterPro annotationAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 152 – 172 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 187 – 218 | Sequence analysisAdd BLAST | 32 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158173 |
HOGENOMi | CLU_013137_14_5_1 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9PMK8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI
60 70 80 90 100
PAQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE
110 120 130 140 150
DPHPLSVVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL
160 170 180 190 200
LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ
210 220 230 240 250
ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT LRQGQEHIGS
260
SCSFAEQALR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75382 | TRIM3_HUMAN | Tripartite motif-containing protein... | TRIM3 BERP, RNF22, RNF97 | 744 | Annotation score: | ||
A0A1W2PPI7 | A0A1W2PPI7_HUMAN | Tripartite motif-containing protein... | TRIM3 | 703 | Annotation score: | ||
E9PMW5 | E9PMW5_HUMAN | Tripartite motif-containing protein... | TRIM3 | 96 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 260 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084337 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000528227; ENSP00000433070; ENSG00000110171 |
UCSCi | uc057ylg.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084337 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PMK8 |
PRIDEi | E9PMK8 |
ProteomicsDBi | 22142 |
Protocols and materials databases
Antibodypediai | 11249, 239 antibodies |
Genome annotation databases
Ensembli | ENST00000528227; ENSP00000433070; ENSG00000110171 |
UCSCi | uc057ylg.1, human |
Organism-specific databases
HGNCi | HGNC:10064, TRIM3 |
OpenTargetsi | ENSG00000110171 |
VEuPathDBi | HostDB:ENSG00000110171.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158173 |
HOGENOMi | CLU_013137_14_5_1 |
Miscellaneous databases
ChiTaRSi | TRIM3, human |
Gene expression databases
Bgeei | ENSG00000110171, Expressed in right hemisphere of cerebellum and 204 other tissues |
ExpressionAtlasi | E9PMK8, baseline and differential |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PMK8_HUMAN | |
Accessioni | E9PMK8Primary (citable) accession number: E9PMK8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 76 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |