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Protein
Submitted name:

E3 ubiquitin-protein ligase synoviolin

Gene

SYVN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase synoviolinImported
Gene namesi
Name:SYVN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162298.16
HGNCiHGNC:20738 SYVN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 60HelicalSequence analysisAdd BLAST18
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei112 – 134HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162298

PTM / Processingi

Proteomic databases

MaxQBiE9PMA1
PeptideAtlasiE9PMA1
PRIDEiE9PMA1

Expressioni

Gene expression databases

BgeeiENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiE9PMA1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PMA1
SMRiE9PMA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0802 Eukaryota
COG5243 LUCA
GeneTreeiENSGT00530000062938

Family and domain databases

InterProiView protein in InterPro
IPR032832 E3_lig_synoviolin/Hrd1
PANTHERiPTHR44251 PTHR44251, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9PMA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL
60 70 80 90 100
LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY
110 120 130 140 150
HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV
160 170 180 190 200
YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL AMRQFKKAVT
210 220 230
DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICRE
Length:236
Mass (Da):27,750
Last modified:April 5, 2011 - v1
Checksum:iA30FCC90F215CAD7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86TM6SYVN1_HUMAN
E3 ubiquitin-protein ligase synovio...
SYVN1 HRD1, KIAA1810
617Annotation score:
H0YCR6H0YCR6_HUMAN
E3 ubiquitin-protein ligase synovio...
SYVN1
149Annotation score:
E9PN88E9PN88_HUMAN
E3 ubiquitin-protein ligase synovio...
SYVN1
149Annotation score:
E9PK19E9PK19_HUMAN
E3 ubiquitin-protein ligase synovio...
SYVN1
237Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei236Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003068 Genomic DNA No translation available.
KF455403 Genomic DNA No translation available.
KF511151 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000531018; ENSP00000431215; ENSG00000162298
UCSCiuc058dgw.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003068 Genomic DNA No translation available.
KF455403 Genomic DNA No translation available.
KF511151 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PMA1
SMRiE9PMA1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9PMA1
PeptideAtlasiE9PMA1
PRIDEiE9PMA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531018; ENSP00000431215; ENSG00000162298
UCSCiuc058dgw.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000162298.16
HGNCiHGNC:20738 SYVN1
OpenTargetsiENSG00000162298
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0802 Eukaryota
COG5243 LUCA
GeneTreeiENSGT00530000062938

Miscellaneous databases

ChiTaRSiSYVN1 human

Gene expression databases

BgeeiENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiE9PMA1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032832 E3_lig_synoviolin/Hrd1
PANTHERiPTHR44251 PTHR44251, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PMA1_HUMAN
AccessioniPrimary (citable) accession number: E9PMA1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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