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Protein

Tyrosine-protein kinase

Gene

TYK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:TYK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105397

PTM / Processingi

Proteomic databases

MaxQBiE9PM19
PeptideAtlasiE9PM19
PRIDEiE9PM19

Expressioni

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiE9PM19 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiE9PM19, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliE9PM19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 246FERMInterPro annotationAdd BLAST246
Domaini404 – 690Protein kinaseInterPro annotationAdd BLAST287
Domaini712 – 991Protein kinaseInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

E9PM19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLHLCHLA LRHGIPLEEV AKKTSFKDCI PRSFRRHIRQ HSALTRLRLR
60 70 80 90 100
NVFRRFLRDF QPGRLSQQMV MVKYLATLER LAPRFGTERV PVCHLRLLAQ
110 120 130 140 150
AEGEPCYIRD SGVAPTDPGP ESAAGPPTHE VLVTGTGGIQ WWPVEEEVNK
160 170 180 190 200
EEGSSGSSGR NPQASLFGKK AKAHKAVGQP ADRPREPLWA YFCDFRDITH
210 220 230 240 250
VVLKEHCVSI HRQDNKCLEL SLPSRAAALS FVSLVDGYFR LTADSSHYLC
260 270 280 290 300
HEVAPPRLVM SIRDGIHGPL LEPFVQAKLR PEDGLYLIHW STSHPYRLIL
310 320 330 340 350
TVAQRSQAPD GMQSLRLRKF PIEQQDGAFV LEGWGRSFPS VRELGAALQG
360 370 380 390 400
CLLRAGDDCF SLRRCCLPQP GETSNLIIMR GARASPRTLN LSQLSFHRVD
410 420 430 440 450
QKEITQLSHL GQGTRTNVYE GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ
460 470 480 490 500
ELRVVLKVLD PSHHDIALAF YETASLMSQV SHTHLAFVHG VCVRGPENIM
510 520 530 540 550
VTEYVEHGPL DVWLRRERGH VPMAWKMVVA QQLASALSYL ENKNLVHGNV
560 570 580 590 600
CGRNILLARL GLAEGTSPFI KLSDPGVGLG ALSREERVER IPWLAPECLP
610 620 630 640 650
GGANSLSTAM DKWGFGATLL EICFDGEAPL QSRSPSEKEH FYQRQHRLPE
660 670 680 690 700
PSCPQLATLT SQCLTYEPTQ RPSFRTILRD LTRLQPHNLA DVLTVNPDSP
710 720 730 740 750
ASDPTVFHKR YLKKIRDLGE GHFGKVSLYC YDPTNDGTGE MVAVKALKAD
760 770 780 790 800
CGPQHRSGWK QEIDILRTLY HEHIIKYKGC CEDQGEKSLQ LVMEYVPLGS
810 820 830 840 850
LRDYLPRHSI GLAQLLLFAQ QICEGMAYLH AQHYIHRDLA ARNVLLDNDR
860 870 880 890 900
LVKIGDFGLA KAVPEGHEYY RVREDGDSPV FWYAPECLKE YKFYYASDVW
910 920 930 940 950
SFGVTLYELL THCDSSQSPP TKFLELIGIA QGQMTVLRLT ELLERGERLP
960 970 980 990 1000
RPDKCPCEVY HLMKNCWETE ASFRPTFENL IPILKTVHEK YQGQAPSVFS

VC
Length:1,002
Mass (Da):112,963
Last modified:April 5, 2011 - v1
Checksum:iA7D1DDCD9CAF88D3
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P29597TYK2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
1,187Annotation score:
E9PPF2E9PPF2_HUMAN
Tyrosine-protein kinase
TYK2
921Annotation score:
K7EJR6K7EJR6_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
142Annotation score:
K7EM33K7EM33_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
135Annotation score:
E9PQL2E9PQL2_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
118Annotation score:
H0YE24H0YE24_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
64Annotation score:
H0YCT7H0YCT7_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
82Annotation score:
H0YE41H0YE41_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
194Annotation score:
E9PQE9E9PQE9_HUMAN
Non-receptor tyrosine-protein kinas...
TYK2
134Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000524462; ENSP00000433203; ENSG00000105397
UCSCiuc010dxe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011557 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PM19
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PM19, 4 interactors

Proteomic databases

MaxQBiE9PM19
PeptideAtlasiE9PM19
PRIDEiE9PM19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524462; ENSP00000433203; ENSG00000105397
UCSCiuc010dxe.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105397.13
HGNCiHGNC:12440 TYK2
OpenTargetsiENSG00000105397
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140909

Miscellaneous databases

ChiTaRSiTYK2 human

Gene expression databases

BgeeiENSG00000105397 Expressed in 226 organ(s), highest expression level in spleen
ExpressionAtlasiE9PM19 baseline and differential

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000299 FERM_domain
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016251 Tyr_kinase_non-rcpt_Jak/Tyk2
IPR016045 Tyr_kinase_non-rcpt_TYK2_N
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 2 hits
PRINTSiPR01823 JANUSKINASE
PR00109 TYRKINASE
PR01827 YKINASETYK2
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00219 TyrKc, 2 hits
SUPFAMiSSF55550 SSF55550, 2 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PM19_HUMAN
AccessioniPrimary (citable) accession number: E9PM19
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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