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Protein
Submitted name:

Proteoglycan 4

Gene

PRG4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Proteoglycan 4Imported
Gene namesi
Name:PRG4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116690.12
HGNCiHGNC:9364 PRG4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500324285725 – 162Sequence analysisAdd BLAST138

Proteomic databases

PeptideAtlasiE9PLR3
PRIDEiE9PLR3

Expressioni

Gene expression databases

BgeeiENSG00000116690 Expressed in 117 organ(s), highest expression level in synovial joint
ExpressionAtlasiE9PLR3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PLR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 67SMBInterPro annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 120Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000063751

Family and domain databases

InterProiView protein in InterPro
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01033 Somatomedin_B, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00201 SO, 1 hit
SUPFAMiSSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9PLR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK
60 70 80 90 100
KYDKCCPDYE SFCAEEHSVS ENQESSSSSS SSSSSSTIRK IKSSKNSAAN
110 120 130 140 150
RELQKKLKVK DNKKNRTKKK PTPKPPVVDE AGSGLDNGDF KVTTPDTSTT
160
QHNKVSTSPK IT
Length:162
Mass (Da):17,982
Last modified:April 5, 2011 - v1
Checksum:i08644135F27FAC5F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q92954PRG4_HUMAN
Proteoglycan 4
PRG4 MSF, SZP
1,404Annotation score:
A0A0U1RR20A0A0U1RR20_HUMAN
Proteoglycan 4
PRG4
1,361Annotation score:
J3KP74J3KP74_HUMAN
Proteoglycan 4
PRG4
853Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei162Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133553 Genomic DNA No translation available.
KF455089 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000533951; ENSP00000431330; ENSG00000116690
UCSCiuc057nyq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133553 Genomic DNA No translation available.
KF455089 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PLR3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PLR3
PRIDEiE9PLR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533951; ENSP00000431330; ENSG00000116690
UCSCiuc057nyq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000116690.12
HGNCiHGNC:9364 PRG4
OpenTargetsiENSG00000116690
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063751

Miscellaneous databases

ChiTaRSiPRG4 human

Gene expression databases

BgeeiENSG00000116690 Expressed in 117 organ(s), highest expression level in synovial joint
ExpressionAtlasiE9PLR3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF01033 Somatomedin_B, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00201 SO, 1 hit
SUPFAMiSSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PLR3_HUMAN
AccessioniPrimary (citable) accession number: E9PLR3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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