UniProtKB - E9PKW8 (E9PKW8_HUMAN)
Protein
Submitted name:
Ubiquitin/ISG15-conjugating enzyme E2 L6
Gene
UBE2L6
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 20 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- transferase activity Source: UniProtKB-KW
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | E9PKW8 |
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin/ISG15-conjugating enzyme E2 L6Imported |
Gene namesi | Name:UBE2L6Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12490, UBE2L6 |
VEuPathDBi | HostDB:ENSG00000156587.15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156587, Expressed in granulocyte and 238 other tissues |
ExpressionAtlasi | E9PKW8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 65 | UBC coreInterPro annotationAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000161981 |
HOGENOMi | CLU_030988_13_4_1 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9PKW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKFTTKIYH PNVDENGQIC LPIISSENWK PCTKTCQVLE ALNVLVNRPN
60
IREPLRMDLA DLLTQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14933 | UB2L6_HUMAN | Ubiquitin/ISG15-conjugating enzyme ... | UBE2L6 UBCH8 | 153 | Annotation score: | ||
E9PQT7 | E9PQT7_HUMAN | Ubiquitin/ISG15-conjugating enzyme ... | UBE2L6 | 127 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 65 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002893 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000527022; ENSP00000435265; ENSG00000156587 |
UCSCi | uc058bms.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002893 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9PKW8 |
PRIDEi | E9PKW8 |
ProteomicsDBi | 21603 |
Protocols and materials databases
Antibodypediai | 1142, 342 antibodies |
Genome annotation databases
Ensembli | ENST00000527022; ENSP00000435265; ENSG00000156587 |
UCSCi | uc058bms.1, human |
Organism-specific databases
HGNCi | HGNC:12490, UBE2L6 |
OpenTargetsi | ENSG00000156587 |
VEuPathDBi | HostDB:ENSG00000156587.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161981 |
HOGENOMi | CLU_030988_13_4_1 |
Enzyme and pathway databases
SignaLinki | E9PKW8 |
Miscellaneous databases
ChiTaRSi | UBE2L6, human |
Gene expression databases
Bgeei | ENSG00000156587, Expressed in granulocyte and 238 other tissues |
ExpressionAtlasi | E9PKW8, baseline and differential |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBIQUITIN_CONJUGAT_1, 1 hit PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PKW8_HUMAN | |
Accessioni | E9PKW8Primary (citable) accession number: E9PKW8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |