UniProtKB - E9PKU7 (E9PKU7_HUMAN)
Protein
Submitted name:
Neutral alpha-glucosidase AB
Gene
GANAB
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- carbohydrate binding Source: InterPro
- hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
Keywordsi
Molecular function | GlycosidaseUniRule annotationARBA annotation, Hydrolase |
Names & Taxonomyi
Protein namesi | Submitted name: Neutral alpha-glucosidase ABImported |
Gene namesi | Name:GANABImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4138, GANAB |
VEuPathDBi | HostDB:ENSG00000089597.16 |
PTM / Processingi
Proteomic databases
EPDi | E9PKU7 |
MaxQBi | E9PKU7 |
PeptideAtlasi | E9PKU7 |
PRIDEi | E9PKU7 |
ProteomicsDBi | 21584 |
PTM databases
MetOSitei | E9PKU7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089597, Expressed in stromal cell of endometrium and 245 other tissues |
ExpressionAtlasi | E9PKU7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 162 – 232 | Gal_mutarotas_2InterPro annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 146 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 142 | PolyampholyteSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000159139 |
HOGENOMi | CLU_000631_7_0_1 |
Family and domain databases
Gene3Di | 2.60.40.1180, 2 hits |
InterProi | View protein in InterPro IPR011013, Gal_mutarotase_sf_dom IPR000322, Glyco_hydro_31 IPR030458, Glyco_hydro_31_AS IPR030459, Glyco_hydro_31_CS IPR025887, Glyco_hydro_31_N_dom IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF |
Pfami | View protein in Pfam PF13802, Gal_mutarotas_2, 1 hit PF01055, Glyco_hydro_31, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF74650, SSF74650, 1 hit |
PROSITEi | View protein in PROSITE PS00129, GLYCOSYL_HYDROL_F31_1, 1 hit PS00707, GLYCOSYL_HYDROL_F31_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PKU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVAAVAAR RRRLSVSGRD ENSVELTMAE GPYKIILTAR PFRLDLLEDR
60 70 80 90 100
SLLLSVNARG LLEFEHQRAP RVSFSDKVNL TLGSIWDKIK NLFSRQGSKD
110 120 130 140 150
PAEGDGAQPE ETPRDGDKPE ETQGKAEKDE PGAWEETFKT HSDSKPYGPM
160 170 180 190 200
SVGLDFSLPG MEHVYGIPEH ADNLRLKVTE GGEPYRLYNL DVFQYELYNP
210 220 230 240 250
MALYGSVPVL LAHNPHRDLG IFWLNAAETW VDISSNTAGK TLFGKMMDYL
260 270 280 290 300
QGSGETPQTD VRWMSETGII DVFLLLGPSI SDVFRQYASL TGTQALPPLF
310 320 330 340 350
SLGYHQSRWN YRDEADVLEV DQGFDDHNLP CDVIWLDIEH ADGKRYFTWD
360 370 380 390 400
PSRFPQPRTM LERLASKRRK LVAIVDPHIK VDSGYRVHEE LRNLGLYVKT
410 420 430 440 450
RDGSDYEGWC WPGSAGYPDF TNPTMRAWWA NMFSYDNYEG SAPNLFVWND
460 470 480 490 500
MNEPSVFNGP EVTMLKDAQH YGGWEHRDVH NIYGLYVHMA TADGLRQRSG
510 520 530 540 550
GMERPFVLAR AFFAGSQRFG AVWTGDNTAE WDHLKISIPM CLSLGLVGLS
560 570 580 590 600
FCGADVGGFF KNPEPELLVR WYQMGAYQPF FRAHAHLDTG RREPWLLPSQ
610 620 630 640 650
HNDIIRDALG QRYSLLPFWY TLLYQAHREG IPVMRPLWVQ YPQDVTTFNI
660 670 680 690 700
DDQYLLGDAL LVHPVSDSGA HGVQVYLPGQ GEVWYDIQSY QKHHGPQTLY
710 720 730 740 750
LPVTLSSIPV FQRGGTIVPR WMRVRRSSEC MKDDPITLFV ALSPQGTAQG
760 770 780 790 800
ELFLDDGHTF NYQTRQEFLL RRFSFSGNTL VSSSADPEGH FETPIWIERV
810 820 830 840 850
VIIGAGKPAA VVLQTKGSPE SRLSFQHDPE TSVLVLRKPG INVASDWSIH
LR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14697 | GANAB_HUMAN | Neutral alpha-glucosidase AB | GANAB G2AN, KIAA0088 | 944 | Annotation score: | ||
F5H6X6 | F5H6X6_HUMAN | Neutral alpha-glucosidase AB | GANAB | 847 | Annotation score: | ||
E9PNH1 | E9PNH1_HUMAN | Neutral alpha-glucosidase AB | GANAB | 119 | Annotation score: | ||
E9PQ69 | E9PQ69_HUMAN | Neutral alpha-glucosidase AB | GANAB | 76 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001458 Genomic DNA No translation available. |
RefSeqi | NP_001265121.1, NM_001278192.1 |
Genome annotation databases
Ensembli | ENST00000534779; ENSP00000435306; ENSG00000089597 |
GeneIDi | 23193 |
UCSCi | uc010rma.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP001458 Genomic DNA No translation available. |
RefSeqi | NP_001265121.1, NM_001278192.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
MetOSitei | E9PKU7 |
Proteomic databases
EPDi | E9PKU7 |
MaxQBi | E9PKU7 |
PeptideAtlasi | E9PKU7 |
PRIDEi | E9PKU7 |
ProteomicsDBi | 21584 |
Protocols and materials databases
Antibodypediai | 14863, 181 antibodies |
Genome annotation databases
Ensembli | ENST00000534779; ENSP00000435306; ENSG00000089597 |
GeneIDi | 23193 |
UCSCi | uc010rma.4, human |
Organism-specific databases
CTDi | 23193 |
HGNCi | HGNC:4138, GANAB |
OpenTargetsi | ENSG00000089597 |
VEuPathDBi | HostDB:ENSG00000089597.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159139 |
HOGENOMi | CLU_000631_7_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 23193, 56 hits in 874 CRISPR screens |
ChiTaRSi | GANAB, human |
GenomeRNAii | 23193 |
Gene expression databases
Bgeei | ENSG00000089597, Expressed in stromal cell of endometrium and 245 other tissues |
ExpressionAtlasi | E9PKU7, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.1180, 2 hits |
InterProi | View protein in InterPro IPR011013, Gal_mutarotase_sf_dom IPR000322, Glyco_hydro_31 IPR030458, Glyco_hydro_31_AS IPR030459, Glyco_hydro_31_CS IPR025887, Glyco_hydro_31_N_dom IPR013780, Glyco_hydro_b IPR017853, Glycoside_hydrolase_SF |
Pfami | View protein in Pfam PF13802, Gal_mutarotas_2, 1 hit PF01055, Glyco_hydro_31, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF74650, SSF74650, 1 hit |
PROSITEi | View protein in PROSITE PS00129, GLYCOSYL_HYDROL_F31_1, 1 hit PS00707, GLYCOSYL_HYDROL_F31_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PKU7_HUMAN | |
Accessioni | E9PKU7Primary (citable) accession number: E9PKU7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |