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UniProtKB - E9PK93 (E9PK93_HUMAN)
Protein
Submitted name:
1,5-anhydro-D-fructose reductase
Gene
AKR1E2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- D-threo-aldose 1-dehydrogenase activity Source: InterPro
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | NADPARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: 1,5-anhydro-D-fructose reductaseImported |
Gene namesi | Name:AKR1E2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23437, AKR1E2 |
VEuPathDBi | HostDB:ENSG00000165568 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165568, Expressed in pancreas and 180 other tissues |
ExpressionAtlasi | E9PK93, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 192 | Aldo_ket_redInterPro annotationAdd BLAST | 176 |
Sequence similaritiesi
Belongs to the aldo/keto reductase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000153272 |
HOGENOMi | CLU_023205_19_0_1 |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PK93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVIFSTAPW PNLPRAQASP GKVTEAVKEA IDAGYRHFDC AYFYHNEREV
60 70 80 90 100
GAGIRCKIKE GAVRREDLFI ATKLWCTCHK KSLVETACRK SLKALKLNYL
110 120 130 140 150
DLYLIHWPMG FKPPHPEWIM SCSELSFCLS HPRVQDLPLD ESNMVIPSDT
160 170 180 190
DFLDTWEAME DLVITGLVKN IGVSNFNHEQ LERLLNKPGL RFKPLTNQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96JD6 | AKCL2_HUMAN | 1,5-anhydro-D-fructose reductase | AKR1E2 AKR1CL2, AKRDC1 | 320 | Annotation score: | ||
G3V1C1 | G3V1C1_HUMAN | 1,5-anhydro-D-fructose reductase | AKR1E2 AKR1CL2, hCG_22604 | 203 | Annotation score: | ||
H0YCI2 | H0YCI2_HUMAN | 1,5-anhydro-D-fructose reductase | AKR1E2 | 56 | Annotation score: | ||
H0YDE8 | H0YDE8_HUMAN | 1,5-anhydro-D-fructose reductase | AKR1E2 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 198 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018978 Genomic DNA No translation available. AC091817 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000533295; ENSP00000435436; ENSG00000165568 |
UCSCi | uc057rhv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018978 Genomic DNA No translation available. AC091817 Genomic DNA No translation available. |
3D structure databases
SMRi | E9PK93 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | E9PK93 |
PRIDEi | E9PK93 |
ProteomicsDBi | 21389 |
Protocols and materials databases
Antibodypediai | 23956, 175 antibodies from 27 providers |
Genome annotation databases
Ensembli | ENST00000533295; ENSP00000435436; ENSG00000165568 |
UCSCi | uc057rhv.1, human |
Organism-specific databases
HGNCi | HGNC:23437, AKR1E2 |
OpenTargetsi | ENSG00000165568 |
VEuPathDBi | HostDB:ENSG00000165568 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153272 |
HOGENOMi | CLU_023205_19_0_1 |
Gene expression databases
Bgeei | ENSG00000165568, Expressed in pancreas and 180 other tissues |
ExpressionAtlasi | E9PK93, baseline and differential |
Family and domain databases
Gene3Di | 3.20.20.100, 1 hit |
InterProi | View protein in InterPro IPR020471, AKR IPR018170, Aldo/ket_reductase_CS IPR023210, NADP_OxRdtase_dom IPR036812, NADP_OxRdtase_dom_sf |
Pfami | View protein in Pfam PF00248, Aldo_ket_red, 1 hit |
PRINTSi | PR00069, ALDKETRDTASE |
SUPFAMi | SSF51430, SSF51430, 1 hit |
PROSITEi | View protein in PROSITE PS00798, ALDOKETO_REDUCTASE_1, 1 hit PS00062, ALDOKETO_REDUCTASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PK93_HUMAN | |
Accessioni | E9PK93Primary (citable) accession number: E9PK93 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | October 5, 2016 | |
Last modified: | January 19, 2022 | |
This is version 66 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |