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Protein
Submitted name:

ADP-ribosylation factor GTPase-activating protein 2

Gene

ARFGAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ADP-ribosylation factor GTPase-activating protein 2Imported
Gene namesi
Name:ARFGAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149182.14
HGNCiHGNC:13504 ARFGAP2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149182

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PK28
PRIDEiE9PK28

Expressioni

Gene expression databases

BgeeiENSG00000149182 Expressed in 224 organ(s), highest expression level in skin of leg
ExpressionAtlasiE9PK28 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 117Arf-GAPInterPro annotationAdd BLAST107

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000005436

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.iShow all

E9PK28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS
60 70 80 90 100
GVHRSLGVHL SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN
110 120 130 140 150
DANTKYNSRA AQMYREKIRQ LGSAALARHG TDLWIDNMSS AVPNHSPEKK
160 170 180 190 200
DSDFFTEHTQ VLVGLGASCQ QEWLTEASVI WPPFQPPAWD APATEPSGTQ
210 220 230
QPAPSTESSG LAQPEHGPNT DLLGTSPKAS LELKSSII
Length:238
Mass (Da):26,038
Last modified:October 5, 2016 - v8
Checksum:i7C335D698721E55E
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8N6H7ARFG2_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2 ZNF289, Nbla10535
521Annotation score:
E9PIY6E9PIY6_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
327Annotation score:
E9PN48E9PN48_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
252Annotation score:
A0A0D9SF70A0A0D9SF70_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2 ZNF289, hCG_1811553
385Annotation score:
G5E9L0G5E9L0_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
493Annotation score:
E9PQP3E9PQP3_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
274Annotation score:
E9PNY8E9PNY8_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
110Annotation score:
E9PM18E9PM18_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
70Annotation score:
E9PM63E9PM63_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
94Annotation score:
E9PMR9E9PMR9_HUMAN
ADP-ribosylation factor GTPase-acti...
ARFGAP2
89Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei238Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090589 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000528444; ENSP00000431684; ENSG00000149182
UCSCiuc058bao.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090589 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PK28
PRIDEiE9PK28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528444; ENSP00000431684; ENSG00000149182
UCSCiuc058bao.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000149182.14
HGNCiHGNC:13504 ARFGAP2
OpenTargetsiENSG00000149182
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000005436

Miscellaneous databases

ChiTaRSiARFGAP2 human

Gene expression databases

BgeeiENSG00000149182 Expressed in 224 organ(s), highest expression level in skin of leg
ExpressionAtlasiE9PK28 baseline and differential

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PK28_HUMAN
AccessioniPrimary (citable) accession number: E9PK28
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 55 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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