UniProtKB - E9PK19 (E9PK19_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase synoviolin
Gene
SYVN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ubiquitin protein ligase activity Source: InterPro
GO - Biological processi
- ubiquitin-dependent ERAD pathway Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase synoviolinImported |
Gene namesi | Name:SYVN1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20738 SYVN1 |
Subcellular locationi
Endoplasmic reticulum
- Hrd1p ubiquitin ligase complex Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 88 – 105 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 157 – 179 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 209 – 230 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
jPOSTi | E9PK19 |
MaxQBi | E9PK19 |
PeptideAtlasi | E9PK19 |
PRIDEi | E9PK19 |
ProteomicsDBi | 21321 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | E9PK19 baseline and differential |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157743 |
Family and domain databases
InterProi | View protein in InterPro IPR032832 E3_lig_synoviolin/Hrd1 |
PANTHERi | PTHR22763:SF173 PTHR22763:SF173, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9PK19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVMGKVF
60 70 80 90 100
FGQLRAAEME HLLERSWYAV TETCLAFTVF RDDFSPRFVA LFTLLLFLKC
110 120 130 140 150
FHWLAEDRVD FMERSPNISW LFHCRIVSLM FLLGILDFLF VSHAYHSILT
160 170 180 190 200
RGASVQLVFG FEYAILMTMV LTIFIKYVLH SVDLQSENPW DNKAVYMLYT
210 220 230
ELFTGFIKVL LYMAFMTIMI KVHTFPLFAI RPMYLAM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86TM6 | SYVN1_HUMAN | E3 ubiquitin-protein ligase synovio... | SYVN1 HRD1, KIAA1810 | 617 | Annotation score: | ||
E9PMA1 | E9PMA1_HUMAN | E3 ubiquitin-protein ligase synovio... | SYVN1 | 236 | Annotation score: | ||
E9PN88 | E9PN88_HUMAN | E3 ubiquitin-protein ligase synovio... | SYVN1 | 149 | Annotation score: | ||
H0YCR6 | H0YCR6_HUMAN | E3 ubiquitin-protein ligase synovio... | SYVN1 | 149 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 237 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003068 Genomic DNA No translation available. KF455403 Genomic DNA No translation available. KF511151 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000528487; ENSP00000431720; ENSG00000162298 |
UCSCi | uc058dha.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003068 Genomic DNA No translation available. KF455403 Genomic DNA No translation available. KF511151 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | E9PK19 |
MaxQBi | E9PK19 |
PeptideAtlasi | E9PK19 |
PRIDEi | E9PK19 |
ProteomicsDBi | 21321 |
Genome annotation databases
Ensembli | ENST00000528487; ENSP00000431720; ENSG00000162298 |
UCSCi | uc058dha.1 human |
Organism-specific databases
HGNCi | HGNC:20738 SYVN1 |
OpenTargetsi | ENSG00000162298 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157743 |
Miscellaneous databases
ChiTaRSi | SYVN1 human |
Gene expression databases
Bgeei | ENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | E9PK19 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR032832 E3_lig_synoviolin/Hrd1 |
PANTHERi | PTHR22763:SF173 PTHR22763:SF173, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9PK19_HUMAN | |
Accessioni | E9PK19Primary (citable) accession number: E9PK19 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | July 31, 2019 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |