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Protein
Submitted name:

Volume-regulated anion channel subunit LRRC8D

Gene

LRRC8D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Volume-regulated anion channel subunit LRRC8DImported
Gene namesi
Name:LRRC8DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171492.14
HGNCiHGNC:16992 LRRC8D

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 42HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171492

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PJS7

Expressioni

Gene expression databases

BgeeiENSG00000171492 Expressed in 235 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE9PJS7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PJS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88Pannexin_likeInterPro annotationAdd BLAST88

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937

Family and domain databases

InterProiView protein in InterPro
IPR038960 LRRC8
IPR021040 LRRC8_Pannexin-like
PANTHERiPTHR43945 PTHR43945, 1 hit
PfamiView protein in Pfam
PF12534 Pannexin_like, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9PJS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD
60 70 80 90 100
QVVCLPVLPS PVNSKAHTPP GNAEVTTNIP KMEAATNQDQ DGRTTNDISF
110 120
GTSAVTPDIP LRATYPRTDF A
Length:121
Mass (Da):13,317
Last modified:October 5, 2016 - v8
Checksum:i0502FF8C3943B4CA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7L1W4LRC8D_HUMAN
Volume-regulated anion channel subu...
LRRC8D LRRC5, UNQ213/PRO239
858Annotation score:
E9PMF9E9PMF9_HUMAN
Volume-regulated anion channel subu...
LRRC8D
274Annotation score:
E9PL08E9PL08_HUMAN
Volume-regulated anion channel subu...
LRRC8D
186Annotation score:
Q5VWA0Q5VWA0_HUMAN
Volume-regulated anion channel subu...
LRRC8D
116Annotation score:
E9PJ89E9PJ89_HUMAN
Volume-regulated anion channel subu...
LRRC8D
30Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei121Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099568 Genomic DNA No translation available.
AL391497 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000532201; ENSP00000435504; ENSG00000171492
UCSCiuc057ifc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099568 Genomic DNA No translation available.
AL391497 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE9PJS7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE9PJS7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532201; ENSP00000435504; ENSG00000171492
UCSCiuc057ifc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000171492.14
HGNCiHGNC:16992 LRRC8D
OpenTargetsiENSG00000171492
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148937

Miscellaneous databases

ChiTaRSiLRRC8D human

Gene expression databases

BgeeiENSG00000171492 Expressed in 235 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE9PJS7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038960 LRRC8
IPR021040 LRRC8_Pannexin-like
PANTHERiPTHR43945 PTHR43945, 1 hit
PfamiView protein in Pfam
PF12534 Pannexin_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9PJS7_HUMAN
AccessioniPrimary (citable) accession number: E9PJS7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 51 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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